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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDPN

Summary for PDPN

Gene information	Gene symbol	PDPN
	Ensembl ID	ENSG00000162493
	Entrez ID	10630
	Gene name	podoplanin
	Synonyms	aggrus\|D2-40\|Gp38\|GP40\|PA2.26\|T1A-2
	Gene type	protein_coding
	UniProtAcc	Q86YL7

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Dataset with differentially expressed gene: PDPN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.4938	8.93e-24

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Expression of PDPN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDPN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDPN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDPN	hsa-miR-3124-3p	92.9261	NM_006474
PDPN	hsa-miR-1827	92.908	NM_006474
PDPN	hsa-miR-199b-5p	91.8987	NM_001006624
PDPN	hsa-miR-199a-5p	91.8987	NM_001006624
PDPN	hsa-miR-6830-3p	91.4797	NM_006474
PDPN	hsa-miR-5191	89.05	NM_006474
PDPN	hsa-miR-548aw	86.5526	NM_006474
PDPN	hsa-miR-3618	85.6501	NM_006474
PDPN	hsa-miR-6740-3p	83.3193	NM_006474
PDPN	hsa-miR-6878-5p	81.9142	NM_006474
PDPN	hsa-miR-7106-5p	81.8654	NM_006474
PDPN	hsa-miR-12126	81.7197	NM_001006624
PDPN	hsa-miR-3120-3p	81.1916	NM_006474
PDPN	hsa-miR-203a-3p	80.6269	NM_006474

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Motifs and transcription factors (TFs) regulating PDPN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDPN	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
PDPN	jaspar__MA1125.1	ZNF384 (directAnnotation).
PDPN	transfac_pro__M07270	TEAD4 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."