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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDLIM5

Summary for PDLIM5

Gene information	Gene symbol	PDLIM5
	Ensembl ID	ENSG00000163110
	Entrez ID	10611
	Gene name	PDZ and LIM domain 5
	Synonyms	Enh\|LIM
	Gene type	protein_coding
	UniProtAcc	Q96HC4

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Dataset with differentially expressed gene: PDLIM5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.373214	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.281759	1.05e-36
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.45837	5.72e-23

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Expression of PDLIM5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDLIM5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDLIM5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDLIM5	hsa-miR-4789-3p	99.4564	NM_001256429
PDLIM5	hsa-miR-548n	98.9908	NM_001011515
PDLIM5	hsa-miR-4282	98.6961	NM_001256426
PDLIM5	hsa-miR-466	98.4203	NM_001256429
PDLIM5	hsa-miR-5003-5p	98.1309	NM_001011515
PDLIM5	hsa-miR-4753-3p	98.0538	NM_001256426
PDLIM5	hsa-miR-5688	98.0475	NM_001256427
PDLIM5	hsa-miR-590-3p	98.0372	NM_001256426
PDLIM5	hsa-miR-495-3p	97.305	NM_001256427
PDLIM5	hsa-miR-4795-3p	96.865	NM_001011513
PDLIM5	hsa-miR-205-3p	96.8334	NM_001011513
PDLIM5	hsa-miR-3163	96.3169	NM_001256426
PDLIM5	hsa-miR-4698	96.0237	NM_001256429
PDLIM5	hsa-let-7f-1-3p	95.1556	NM_001256429
PDLIM5	hsa-let-7a-3p	95.1556	NM_001256429
PDLIM5	hsa-miR-98-3p	95.1556	NM_001256429
PDLIM5	hsa-let-7b-3p	95.1556	NM_001256429
PDLIM5	hsa-miR-323b-3p	94.8178	NM_001256427
PDLIM5	hsa-miR-5692c	94.7321	NM_001011515
PDLIM5	hsa-miR-5692b	94.7321	NM_001011515
PDLIM5	hsa-miR-7-2-3p	94.6944	NM_001256427
PDLIM5	hsa-miR-7-1-3p	94.6944	NM_001256427
PDLIM5	hsa-miR-6516-5p	94.6341	NM_001256429
PDLIM5	hsa-miR-548ah-5p	93.5002	NM_001256429
PDLIM5	hsa-miR-3609	93.5002	NM_001256429
PDLIM5	hsa-miR-4531	92.6713	NM_001256427
PDLIM5	hsa-miR-4699-3p	92.6488	NM_001256426
PDLIM5	hsa-miR-376a-2-5p	92.6411	NM_001256427
PDLIM5	hsa-miR-3714	92.109	NM_001011515
PDLIM5	hsa-miR-4756-5p	92.0195	NM_001256427
PDLIM5	hsa-miR-1321	92.0195	NM_001256427
PDLIM5	hsa-miR-4739	92.0195	NM_001256427
PDLIM5	hsa-miR-300	91.5438	NM_001256426
PDLIM5	hsa-miR-381-3p	91.5438	NM_001256426
PDLIM5	hsa-miR-4643	91.0116	NM_001256429
PDLIM5	hsa-miR-4735-5p	90.6266	NM_001256426
PDLIM5	hsa-miR-5011-5p	90.5967	NM_001256429
PDLIM5	hsa-miR-126-5p	90.5547	NM_001011513
PDLIM5	hsa-miR-4666a-3p	90.0798	NM_001256426
PDLIM5	hsa-miR-506-3p	89.9617	NM_001011515
PDLIM5	hsa-miR-124-3p	89.9617	NM_001011515
PDLIM5	hsa-miR-4786-3p	89.9542	NM_001256426
PDLIM5	hsa-miR-4637	89.7107	NM_001256429
PDLIM5	hsa-miR-3910	89.5173	NM_001011515
PDLIM5	hsa-miR-12124	89.5089	NM_001011515
PDLIM5	hsa-miR-6505-3p	89.3738	NM_001256427
PDLIM5	hsa-miR-3127-5p	89.2636	NM_001256426
PDLIM5	hsa-miR-4729	89.2024	NM_001011513
PDLIM5	hsa-miR-4271	89.1027	NM_001256426
PDLIM5	hsa-miR-4725-3p	88.874	NM_001256426

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Motifs and transcription factors (TFs) regulating PDLIM5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDLIM5	metacluster_7.13	ZFX (directAnnotation).
PDLIM5	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PDLIM5	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PDLIM5	metacluster_151.2	ZNF23 (directAnnotation).
PDLIM5	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PDLIM5	transfac_pro__M05479	ZNF580 (directAnnotation).
PDLIM5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PDLIM5	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PDLIM5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PDLIM5	hdpi__ETV4	ETV4 (directAnnotation).
PDLIM5	jaspar__MA0748.2	YY2 (directAnnotation).
PDLIM5	transfac_pro__M05628	ZNF735 (directAnnotation).
PDLIM5	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PDLIM5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PDLIM5	jaspar__MA1933.1	SREBF2 (directAnnotation).
PDLIM5	jaspar__MA0079.5	SP1 (directAnnotation).
PDLIM5	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
PDLIM5	transfac_pro__M04826	EP300 (directAnnotation).
PDLIM5	metacluster_135.11	NR2C2 (directAnnotation).
PDLIM5	tfdimers__MD00038	TFAP2C (directAnnotation).
PDLIM5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PDLIM5	cisbp__M00968	MTF2 (directAnnotation).
PDLIM5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PDLIM5	cisbp__M00341	PAX6 (directAnnotation).
PDLIM5	metacluster_198.3	ZFP64 (directAnnotation).
PDLIM5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PDLIM5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PDLIM5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PDLIM5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PDLIM5	cisbp__M00788	ZFY (inferredBy_Orthology).
PDLIM5	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PDLIM5	metacluster_175.1	ZNF283 (directAnnotation).
PDLIM5	hdpi__ZNF304	ZNF304 (directAnnotation).
PDLIM5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PDLIM5	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PDLIM5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PDLIM5	transfac_pro__M01199	TRIM28 (directAnnotation).
PDLIM5	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PDLIM5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PDLIM5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PDLIM5	transfac_pro__M03806	ZBTB7C (directAnnotation).
PDLIM5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PDLIM5	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PDLIM5	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PDLIM5	transfac_pro__M02089	E2F3 (directAnnotation).
PDLIM5	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PDLIM5	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PDLIM5	transfac_pro__M04817	ZBTB33 (directAnnotation).
PDLIM5	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PDLIM5	tfdimers__MD00483	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."