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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PDK4

Summary for PDK4

Gene information	Gene symbol	PDK4
	Ensembl ID	ENSG00000004799
	Entrez ID	5166
	Gene name	pyruvate dehydrogenase kinase 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q16654

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Dataset with differentially expressed gene: PDK4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.425765	8.16e-13

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Expression of PDK4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDK4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDK4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDK4	hsa-miR-9-5p	94.7981	NM_002612
PDK4	hsa-miR-8485	94.4447	NM_002612
PDK4	hsa-miR-30d-3p	94.3673	NM_002612
PDK4	hsa-miR-30e-3p	94.3673	NM_002612
PDK4	hsa-miR-30a-3p	94.3673	NM_002612
PDK4	hsa-miR-4666a-5p	92.6558	NM_002612
PDK4	hsa-miR-6832-5p	92.6133	NM_002612
PDK4	hsa-miR-3123	92.0237	NM_002612
PDK4	hsa-miR-4482-3p	88.8775	NM_002612
PDK4	hsa-miR-548ah-5p	88.2963	NM_002612
PDK4	hsa-miR-122-5p	87.9579	NM_002612
PDK4	hsa-miR-6796-5p	87.0627	NM_002612
PDK4	hsa-miR-545-5p	86.9913	NM_002612
PDK4	hsa-miR-491-5p	86.3734	NM_002612
PDK4	hsa-miR-3609	85.8017	NM_002612
PDK4	hsa-miR-2861	85.7779	NM_002612
PDK4	hsa-miR-27a-3p	85.6296	NM_002612
PDK4	hsa-miR-27b-3p	85.6296	NM_002612
PDK4	hsa-miR-9985	85.6296	NM_002612
PDK4	hsa-miR-6838-5p	84.8087	NM_002612
PDK4	hsa-miR-15b-5p	84.8087	NM_002612
PDK4	hsa-miR-424-5p	84.8087	NM_002612
PDK4	hsa-miR-497-5p	84.8087	NM_002612
PDK4	hsa-miR-195-5p	84.8087	NM_002612
PDK4	hsa-miR-15a-5p	84.8087	NM_002612
PDK4	hsa-miR-16-5p	84.8087	NM_002612
PDK4	hsa-miR-205-3p	83.7949	NM_002612
PDK4	hsa-miR-3941	83.5817	NM_002612
PDK4	hsa-miR-4424	83.2334	NM_002612
PDK4	hsa-miR-4659b-3p	81.3231	NM_002612
PDK4	hsa-miR-4659a-3p	81.3231	NM_002612
PDK4	hsa-miR-6868-3p	80.2161	NM_002612

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Motifs and transcription factors (TFs) regulating PDK4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDK4	cisbp__M00341	PAX6 (directAnnotation).
PDK4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PDK4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PDK4	metacluster_175.1	ZNF283 (directAnnotation).
PDK4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PDK4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PDK4	"4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol"	DB08356	small molecule
PDK4	"Tretinoin"	DB00755	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."