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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PDK1

Summary for PDK1

Gene information	Gene symbol	PDK1
	Ensembl ID	ENSG00000152256
	Entrez ID	5163
	Gene name	pyruvate dehydrogenase kinase 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PDK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.25399	2.08e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.561769	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.289403	3.35e-16
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.456327	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.308516	8.26e-19

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Expression of PDK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDK1	hsa-miR-548c-3p	98.338	NM_002610
PDK1	hsa-miR-30a-3p	97.939	NM_002610
PDK1	hsa-miR-30e-3p	97.939	NM_002610
PDK1	hsa-miR-30d-3p	97.939	NM_002610
PDK1	hsa-miR-548k	94.453	NM_002610
PDK1	hsa-miR-8054	94.453	NM_002610
PDK1	hsa-miR-548av-5p	94.453	NM_002610
PDK1	hsa-miR-3163	91.2177	NM_002610
PDK1	hsa-miR-4282	88.8738	NM_002610
PDK1	hsa-miR-6516-5p	87.8383	NM_002610
PDK1	hsa-miR-8068	87.2114	NM_002610
PDK1	hsa-miR-8071	86.043	NM_002610
PDK1	hsa-miR-548l	85.4593	NM_002610
PDK1	hsa-miR-9-3p	85.2594	NM_002610
PDK1	hsa-miR-607	84.1618	NM_002610
PDK1	hsa-miR-5189-5p	83.2184	NM_002610
PDK1	hsa-miR-136-5p	83.0888	NM_002610
PDK1	hsa-miR-34b-3p	82.8884	NM_002610
PDK1	hsa-miR-3688-3p	82.7286	NM_002610
PDK1	hsa-let-7c-3p	81.0869	NM_002610
PDK1	hsa-miR-885-5p	81.0279	NM_002610
PDK1	hsa-miR-942-5p	80.377	NM_002610
PDK1	hsa-miR-320b	80.2356	NM_002610
PDK1	hsa-miR-320d	80.2356	NM_002610
PDK1	hsa-miR-320a-3p	80.2356	NM_002610
PDK1	hsa-miR-320c	80.2356	NM_002610
PDK1	hsa-miR-4429	80.2356	NM_002610

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Motifs and transcription factors (TFs) regulating PDK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDK1	jaspar__MA0039.4	KLF4 (directAnnotation).
PDK1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
PDK1	transfac_pro__M04595	SALL2 (directAnnotation).
PDK1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PDK1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
PDK1	transfac_pro__M06085	ZNF26 (directAnnotation).
PDK1	transfac_pro__M06388	ZNF677 (directAnnotation).
PDK1	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
PDK1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PDK1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PDK1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
PDK1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
PDK1	metacluster_151.2	ZNF23 (directAnnotation).
PDK1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PDK1	tfdimers__MD00391	KLF4 (directAnnotation).
PDK1	transfac_pro__M05479	ZNF580 (directAnnotation).
PDK1	tfdimers__MD00151	CHURC1 (directAnnotation).
PDK1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PDK1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
PDK1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PDK1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PDK1	tfdimers__MD00038	TFAP2C (directAnnotation).
PDK1	transfac_pro__M12697	ZNF142 (directAnnotation).
PDK1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PDK1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PDK1	transfac_pro__M01714	KLF15 (directAnnotation).
PDK1	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
PDK1	transfac_pro__M00938	E2F1 (directAnnotation).
PDK1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PDK1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PDK1	swissregulon__hs__PATZ1	PATZ1 (directAnnotation).
PDK1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PDK1	transfac_pro__M06441	ZSCAN30 (directAnnotation).
PDK1	kznf__ZNF33A_Schmitges2016_RCADE	ZNF33A (directAnnotation).
PDK1	taipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNTGCGGG_CAP	FIGLA; GCM1 (directAnnotation).
PDK1	taipale_cyt_meth__HSF5_NRCGTTCTAGAAYGYN_eDBD_repr	HSF5 (directAnnotation).
PDK1	taipale__IRF7_DBD_RAANCGAAAWTCGNTTY_repr	IRF7 (directAnnotation).
PDK1	transfac_pro__M06226	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PDK1	"4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETH	DB07403	small molecule
PDK1	"Dichloroacetic acid"	DB08809	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."