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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDHX

Summary for PDHX

Gene information	Gene symbol	PDHX
	Ensembl ID	ENSG00000110435
	Entrez ID	8050
	Gene name	pyruvate dehydrogenase complex component X
	Synonyms	DLDBP\|E3BP\|OPDX\|PDX1\|proX
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PDHX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.263532	1.97e-18
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.273952	2.07e-11

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Expression of PDHX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDHX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDHX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDHX	hsa-miR-128-3p	94.1564	NM_001135024
PDHX	hsa-miR-216a-3p	94.1564	NM_001135024
PDHX	hsa-miR-3681-3p	94.0854	NM_001135024
PDHX	hsa-miR-302c-5p	92.4654	NM_003477
PDHX	hsa-miR-3143	89.9816	NM_003477
PDHX	hsa-miR-27b-3p	89.1974	NM_001135024
PDHX	hsa-miR-27a-3p	89.1974	NM_001135024
PDHX	hsa-miR-9985	89.1974	NM_001135024
PDHX	hsa-miR-5692a	89.1116	NM_001135024
PDHX	hsa-miR-3065-3p	88.3855	NM_001135024
PDHX	hsa-miR-1297	88.032	NM_001135024
PDHX	hsa-miR-130b-5p	87.1167	NM_003477
PDHX	hsa-miR-211-5p	86.6347	NM_003477
PDHX	hsa-miR-204-5p	86.6347	NM_003477
PDHX	hsa-miR-26b-5p	85.5435	NM_001135024
PDHX	hsa-miR-26a-5p	85.5435	NM_001135024
PDHX	hsa-miR-409-3p	84.3531	NM_001135024
PDHX	hsa-miR-1-5p	83.5578	NM_003477
PDHX	hsa-miR-4465	82.9011	NM_001135024
PDHX	hsa-miR-338-5p	81.1953	NM_003477
PDHX	hsa-miR-5680	80.3242	NM_003477

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Motifs and transcription factors (TFs) regulating PDHX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDHX	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PDHX	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PDHX	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
PDHX	metacluster_81.7	CREB1 (directAnnotation).
PDHX	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."