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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PDHA1

Summary for PDHA1

Gene information	Gene symbol	PDHA1
	Ensembl ID	ENSG00000131828
	Entrez ID	5160
	Gene name	pyruvate dehydrogenase E1 subunit alpha 1
	Synonyms	E1alpha\|PDHA
	Gene type	protein_coding
	UniProtAcc	P08559

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Dataset with differentially expressed gene: PDHA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.29236	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.346885	1.95e-25
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.354159	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.890125	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.928813	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.946106	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.599458	6.76e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.700584	0.00e+00

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Expression of PDHA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDHA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDHA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDHA1	hsa-miR-4709-3p	96.9287	NM_001173454
PDHA1	hsa-miR-5688	94.7352	NM_001173454
PDHA1	hsa-miR-548m	94.1154	NM_000284
PDHA1	hsa-miR-1306-5p	93.6379	NM_001173454
PDHA1	hsa-miR-570-5p	93.287	NM_000284
PDHA1	hsa-miR-548ai	93.287	NM_000284
PDHA1	hsa-miR-548ag	93.287	NM_000284
PDHA1	hsa-miR-548ba	93.287	NM_000284
PDHA1	hsa-miR-495-3p	92.7437	NM_001173454
PDHA1	hsa-miR-4463	92.4757	NM_000284
PDHA1	hsa-miR-6832-5p	90.9752	NM_001173454
PDHA1	hsa-miR-3942-3p	90.6952	NM_000284
PDHA1	hsa-miR-584-5p	89.8637	NM_001173454
PDHA1	hsa-miR-3529-3p	87.6919	NM_001173454
PDHA1	hsa-miR-4789-5p	85.808	NM_000284
PDHA1	hsa-miR-653-5p	83.2624	NM_001173454
PDHA1	hsa-miR-7849-3p	82.8973	NM_000284
PDHA1	hsa-miR-1276	82.0953	NM_001173454
PDHA1	hsa-miR-203a-3p	81.764	NM_001173454
PDHA1	hsa-miR-616-5p	80.8855	NM_001173454
PDHA1	hsa-miR-371b-5p	80.8855	NM_001173454
PDHA1	hsa-miR-373-5p	80.8855	NM_001173454
PDHA1	hsa-miR-10b-3p	80.6801	NM_000284

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Motifs and transcription factors (TFs) regulating PDHA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDHA1	hdpi__TP73	TP73 (directAnnotation).
PDHA1	metacluster_55.5	ZNF541 (directAnnotation).
PDHA1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PDHA1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
PDHA1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
PDHA1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
PDHA1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
PDHA1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
PDHA1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
PDHA1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
PDHA1	transfac_pro__M06032	ZNF727 (directAnnotation).
PDHA1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
PDHA1	jaspar__MA0502.2	NFYB (directAnnotation).
PDHA1	cisbp__M00808	MYPOP (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PDHA1	"NADH"	DB00157	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."