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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDE4DIP

Summary for PDE4DIP

Gene information	Gene symbol	PDE4DIP
	Ensembl ID	ENSG00000178104
	Entrez ID	9659
	Gene name	phosphodiesterase 4D interacting protein
	Synonyms	CMYA2\|KIAA0454\|KIAA0477\|MMGL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PDE4DIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.287207	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.324321	6.05e-27
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.263021	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.269136	1.56e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.652898	0.00e+00

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Expression of PDE4DIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDE4DIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDE4DIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDE4DIP	hsa-miR-4789-5p	97.8571	NM_001198834
PDE4DIP	hsa-miR-580-3p	91.4051	NM_001002812
PDE4DIP	hsa-miR-548ao-5p	90.0084	NM_001002812
PDE4DIP	hsa-miR-548ax	90.0084	NM_001002812
PDE4DIP	hsa-miR-106a-3p	89.8052	NM_001002812
PDE4DIP	hsa-miR-9902	89.3917	NM_001002812
PDE4DIP	hsa-miR-498-5p	87.8972	NM_001002812
PDE4DIP	hsa-miR-6828-5p	87.1004	NM_001002812
PDE4DIP	hsa-miR-6875-3p	84.7918	NM_001002812
PDE4DIP	hsa-miR-508-5p	82.6708	NM_001002812
PDE4DIP	hsa-miR-345-3p	82.5158	NM_001002810
PDE4DIP	hsa-miR-3978	81.7866	NM_001002812
PDE4DIP	hsa-miR-5004-5p	81.7311	NM_001002812
PDE4DIP	hsa-miR-181a-2-3p	81.4677	NM_001002810
PDE4DIP	hsa-miR-6740-3p	81.1665	NM_001002812
PDE4DIP	hsa-miR-455-3p	80.9329	NM_001198834

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Motifs and transcription factors (TFs) regulating PDE4DIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDE4DIP	metacluster_151.2	ZNF23 (directAnnotation).
PDE4DIP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PDE4DIP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PDE4DIP	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PDE4DIP	transfac_pro__M05628	ZNF735 (directAnnotation).
PDE4DIP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PDE4DIP	jaspar__MA0079.5	SP1 (directAnnotation).
PDE4DIP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PDE4DIP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PDE4DIP	transfac_pro__M07397	ZNF148 (directAnnotation).
PDE4DIP	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PDE4DIP	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PDE4DIP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PDE4DIP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PDE4DIP	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PDE4DIP	transfac_pro__M01175	ZBTB7B (directAnnotation).
PDE4DIP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PDE4DIP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PDE4DIP	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PDE4DIP	transfac_pro__M01303	SP1 (directAnnotation).
PDE4DIP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PDE4DIP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PDE4DIP	transfac_pro__M02090	E2F4 (directAnnotation).
PDE4DIP	transfac_pro__M01714	KLF15 (directAnnotation).
PDE4DIP	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PDE4DIP	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PDE4DIP	transfac_pro__M02089	E2F3 (directAnnotation).
PDE4DIP	metacluster_3.14	WT1; WT1 (directAnnotation).
PDE4DIP	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
PDE4DIP	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PDE4DIP	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PDE4DIP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PDE4DIP	cisbp__M07938	E2F1 (directAnnotation).
PDE4DIP	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PDE4DIP	transfac_pro__M07436	WT1 (directAnnotation).
PDE4DIP	transfac_pro__M02281	SP1 (directAnnotation).
PDE4DIP	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PDE4DIP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PDE4DIP	transfac_pro__M02898	SMAD3 (directAnnotation).
PDE4DIP	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PDE4DIP	cisbp__M00161	FOXJ1 (inferredBy_Orthology).
PDE4DIP	transfac_pro__M01835	KLF4 (directAnnotation).
PDE4DIP	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
PDE4DIP	swissregulon__hs__MTA3	MTA3 (directAnnotation).
PDE4DIP	transfac_pro__M06129	GLI4 (directAnnotation).
PDE4DIP	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
PDE4DIP	metacluster_155.35	FIZ1; ZNF322 (directAnnotation). ZNF322 (inferredBy_Orthology).
PDE4DIP	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
PDE4DIP	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
PDE4DIP	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."