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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PDE3B

Summary for PDE3B

Gene information	Gene symbol	PDE3B
	Ensembl ID	ENSG00000152270
	Entrez ID	5140
	Gene name	phosphodiesterase 3B
	Synonyms	HcGIP1
	Gene type	protein_coding
	UniProtAcc	Q13370

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Dataset with differentially expressed gene: PDE3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.432296	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.260425	8.78e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.309983	6.30e-15

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Expression of PDE3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDE3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDE3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDE3B	hsa-miR-519c-3p	97.2333	NM_000922
PDE3B	hsa-miR-519a-3p	97.2333	NM_000922
PDE3B	hsa-miR-519b-3p	97.2333	NM_000922
PDE3B	hsa-miR-641	95.8881	NM_000922
PDE3B	hsa-miR-3617-5p	95.8881	NM_000922
PDE3B	hsa-miR-4711-5p	95.7356	NM_000922
PDE3B	hsa-miR-4282	95.7124	NM_000922
PDE3B	hsa-miR-186-5p	95.0208	NM_000922
PDE3B	hsa-miR-590-3p	94.6255	NM_000922
PDE3B	hsa-miR-20a-5p	94.2173	NM_000922
PDE3B	hsa-miR-17-5p	94.2173	NM_000922
PDE3B	hsa-miR-93-5p	94.2173	NM_000922
PDE3B	hsa-miR-106a-5p	94.2173	NM_000922
PDE3B	hsa-miR-106b-5p	94.2173	NM_000922
PDE3B	hsa-miR-519d-3p	94.2173	NM_000922
PDE3B	hsa-miR-20b-5p	94.2173	NM_000922
PDE3B	hsa-miR-205-5p	94.0136	NM_000922
PDE3B	hsa-miR-605-5p	92.3032	NM_000922
PDE3B	hsa-miR-548e-5p	92.0659	NM_000922
PDE3B	hsa-miR-514b-5p	91.6337	NM_000922
PDE3B	hsa-miR-513c-5p	91.6337	NM_000922
PDE3B	hsa-miR-107	91.201	NM_000922
PDE3B	hsa-miR-103a-3p	91.201	NM_000922
PDE3B	hsa-miR-526b-3p	91.1526	NM_000922
PDE3B	hsa-miR-7111-3p	89.1317	NM_000922
PDE3B	hsa-miR-196a-1-3p	88.7238	NM_000922
PDE3B	hsa-miR-1200	88.6381	NM_000922
PDE3B	hsa-miR-27b-3p	88.1431	NM_000922
PDE3B	hsa-miR-9985	88.1431	NM_000922
PDE3B	hsa-miR-27a-3p	88.1431	NM_000922
PDE3B	hsa-miR-5692a	87.913	NM_000922
PDE3B	hsa-miR-144-3p	87.9075	NM_000922
PDE3B	hsa-miR-10394-5p	87.2006	NM_000922
PDE3B	hsa-miR-1205	87.2006	NM_000922
PDE3B	hsa-miR-15a-5p	87.1203	NM_000922
PDE3B	hsa-miR-6838-5p	87.1203	NM_000922
PDE3B	hsa-miR-497-5p	87.1203	NM_000922
PDE3B	hsa-miR-15b-5p	87.1203	NM_000922
PDE3B	hsa-miR-424-5p	87.1203	NM_000922
PDE3B	hsa-miR-16-5p	87.1203	NM_000922
PDE3B	hsa-miR-195-5p	87.1203	NM_000922
PDE3B	hsa-miR-4743-3p	86.8438	NM_000922
PDE3B	hsa-miR-7157-5p	86.4292	NM_000922
PDE3B	hsa-miR-515-5p	86.0899	NM_000922
PDE3B	hsa-miR-519e-5p	86.0899	NM_000922
PDE3B	hsa-miR-4531	86.0544	NM_000922
PDE3B	hsa-miR-548ao-5p	85.7375	NM_000922
PDE3B	hsa-miR-548ax	85.7375	NM_000922
PDE3B	hsa-miR-6769b-3p	85.6124	NM_000922
PDE3B	hsa-miR-4723-3p	85.6124	NM_000922

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Motifs and transcription factors (TFs) regulating PDE3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDE3B	transfac_pro__M05481	ZNF202 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PDE3B	"3-isobutyl-1-methyl-7H-xanthine"	DB07954	small molecule
PDE3B	"6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-o	DB01640	small molecule
PDE3B	"Amrinone"	DB01427	small molecule
PDE3B	"Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide"	DB01970	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."