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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDE12

Summary for PDE12

Gene information	Gene symbol	PDE12
	Ensembl ID	ENSG00000174840
	Entrez ID	201626
	Gene name	phosphodiesterase 12
	Synonyms	2'-PDE\|3635\|DKFZp667B1218
	Gene type	protein_coding
	UniProtAcc	Q6L8Q7

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Dataset with differentially expressed gene: PDE12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.341004	8.02e-38

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Expression of PDE12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDE12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDE12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDE12	hsa-miR-5011-5p	94.6391	NM_177966
PDE12	hsa-miR-1224-3p	93.4447	NM_001322177
PDE12	hsa-miR-190a-3p	92.9164	NM_177966
PDE12	hsa-miR-4500	91.4999	NM_001322177
PDE12	hsa-miR-1250-3p	91.1066	NM_177966
PDE12	hsa-miR-5582-5p	90.7501	NM_001322177
PDE12	hsa-miR-4528	90.0024	NM_177966
PDE12	hsa-miR-576-5p	88.8134	NM_001322177
PDE12	hsa-miR-5688	88.7988	NM_177966
PDE12	hsa-miR-495-3p	88.4449	NM_177966
PDE12	hsa-miR-3662	88.1061	NM_001322177
PDE12	hsa-miR-4468	86.8265	NM_177966
PDE12	hsa-miR-4635	86.3236	NM_001322177
PDE12	hsa-miR-371b-5p	85.9261	NM_177966
PDE12	hsa-miR-616-5p	85.9261	NM_177966
PDE12	hsa-miR-373-5p	85.9261	NM_177966
PDE12	hsa-let-7e-5p	85.9146	NM_001322177
PDE12	hsa-let-7b-5p	85.9146	NM_001322177
PDE12	hsa-let-7c-5p	85.9146	NM_001322177
PDE12	hsa-miR-98-5p	85.9146	NM_001322177
PDE12	hsa-let-7i-5p	85.9146	NM_001322177
PDE12	hsa-let-7a-5p	85.9146	NM_001322177
PDE12	hsa-let-7g-5p	85.9146	NM_001322177
PDE12	hsa-let-7f-5p	85.9146	NM_001322177
PDE12	hsa-miR-548l	85.8325	NM_177966
PDE12	hsa-miR-4422	85.5094	NM_001322177
PDE12	hsa-miR-4531	85.4959	NM_177966
PDE12	hsa-miR-586	85.2852	NM_001322177
PDE12	hsa-miR-4255	85.1333	NM_177966
PDE12	hsa-miR-494-3p	85.0385	NM_001322177
PDE12	hsa-miR-3163	84.7087	NM_001322177
PDE12	hsa-miR-335-3p	84.0721	NM_177966
PDE12	hsa-miR-6749-3p	83.9783	NM_001322177
PDE12	hsa-miR-5006-5p	83.914	NM_001322177
PDE12	hsa-miR-558	83.4417	NM_177966
PDE12	hsa-miR-30e-3p	83.421	NM_001322177
PDE12	hsa-miR-30d-3p	83.421	NM_001322177
PDE12	hsa-miR-30a-3p	83.421	NM_001322177
PDE12	hsa-miR-12131	83.0067	NM_177966
PDE12	hsa-miR-206	82.8431	NM_001322177
PDE12	hsa-miR-511-5p	82.0197	NM_001322177
PDE12	hsa-miR-153-5p	81.7823	NM_177966
PDE12	hsa-miR-513b-5p	81.6859	NM_177966
PDE12	hsa-let-7d-5p	81.2473	NM_001322177
PDE12	hsa-miR-4458	81.2473	NM_001322177
PDE12	hsa-miR-1266-3p	80.8305	NM_001322177
PDE12	hsa-miR-138-2-3p	80.6615	NM_001322177
PDE12	hsa-miR-382-3p	80.5894	NM_001322177
PDE12	hsa-miR-3125	80.0804	NM_177966

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Motifs and transcription factors (TFs) regulating PDE12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."