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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PDCD10

Summary for PDCD10

Gene information	Gene symbol	PDCD10
	Ensembl ID	ENSG00000114209
	Entrez ID	11235
	Gene name	programmed cell death 10
	Synonyms	CCM3\|TFAR15
	Gene type	protein_coding
	UniProtAcc	Q9BUL8

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Dataset with differentially expressed gene: PDCD10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.28963	3.65e-15
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.303098	2.98e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.254973	8.91e-16
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.290159	4.71e-07
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.499051	3.79e-36
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.497716	1.08e-23
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.462912	1.52e-25
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.37077	1.33e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.467111	1.98e-29

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Expression of PDCD10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDCD10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
PDCD10	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating PDCD10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDCD10	hsa-miR-613	95.7164	NM_145859
PDCD10	hsa-miR-206	95.7164	NM_145859
PDCD10	hsa-miR-1-3p	95.7164	NM_145859
PDCD10	hsa-miR-4315	94.7826	NM_145859
PDCD10	hsa-miR-4715-3p	94.5967	NM_145859
PDCD10	hsa-miR-4302	94.1078	NM_145859
PDCD10	hsa-miR-4477b	94.0254	NM_145859
PDCD10	hsa-miR-524-5p	93.9846	NM_145859
PDCD10	hsa-miR-520d-5p	93.9846	NM_145859
PDCD10	hsa-miR-4282	93.3813	NM_145859
PDCD10	hsa-miR-4252	93.1487	NM_145859
PDCD10	hsa-miR-642a-3p	92.2999	NM_145859
PDCD10	hsa-miR-642b-3p	92.2999	NM_145859
PDCD10	hsa-miR-5683	90.3428	NM_145859
PDCD10	hsa-miR-548p	89.3689	NM_145859
PDCD10	hsa-miR-5583-3p	89.2021	NM_145859
PDCD10	hsa-miR-7856-5p	89.1471	NM_145859
PDCD10	hsa-miR-1468-3p	88.0935	NM_145859
PDCD10	hsa-miR-21-3p	88.0074	NM_145859
PDCD10	hsa-miR-122b-3p	88.0074	NM_145859
PDCD10	hsa-let-7f-2-3p	86.6254	NM_145859
PDCD10	hsa-miR-1185-2-3p	86.6254	NM_145859
PDCD10	hsa-miR-1185-1-3p	86.6254	NM_145859
PDCD10	hsa-miR-30c-5p	86.2497	NM_145859
PDCD10	hsa-miR-30b-5p	86.2497	NM_145859
PDCD10	hsa-miR-30a-5p	86.2497	NM_145859
PDCD10	hsa-miR-30d-5p	86.2497	NM_145859
PDCD10	hsa-miR-30e-5p	86.2497	NM_145859
PDCD10	hsa-miR-103a-3p	85.8932	NM_145859
PDCD10	hsa-miR-107	85.8932	NM_145859
PDCD10	hsa-miR-548f-5p	85.0788	NM_145859
PDCD10	hsa-miR-548g-5p	85.0788	NM_145859
PDCD10	hsa-miR-548aj-5p	85.0788	NM_145859
PDCD10	hsa-miR-548x-5p	85.0788	NM_145859
PDCD10	hsa-miR-5585-5p	84.1084	NM_145859
PDCD10	hsa-miR-3064-3p	84.0109	NM_145859
PDCD10	hsa-miR-425-5p	83.8575	NM_145859
PDCD10	hsa-miR-548an	83.5529	NM_145859
PDCD10	hsa-miR-12121	83.2625	NM_145859
PDCD10	hsa-miR-2053	82.8873	NM_145859
PDCD10	hsa-miR-4793-5p	82.4224	NM_145859
PDCD10	hsa-miR-32-3p	81.938	NM_145859
PDCD10	hsa-miR-3199	81.9372	NM_145859
PDCD10	hsa-miR-8052	81.9372	NM_145859
PDCD10	hsa-miR-4426	81.2796	NM_145859
PDCD10	hsa-miR-4662b	81.2796	NM_145859
PDCD10	hsa-miR-4647	81.2796	NM_145859

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Motifs and transcription factors (TFs) regulating PDCD10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDCD10	metacluster_135.11	NR2C2 (directAnnotation).
PDCD10	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PDCD10	tfdimers__MD00038	TFAP2C (directAnnotation).
PDCD10	metacluster_7.13	ZFX (directAnnotation).
PDCD10	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PDCD10	cisbp__M00968	MTF2 (directAnnotation).
PDCD10	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PDCD10	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PDCD10	cisbp__M00341	PAX6 (directAnnotation).
PDCD10	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PDCD10	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PDCD10	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PDCD10	cisbp__M00788	ZFY (inferredBy_Orthology).
PDCD10	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PDCD10	metacluster_175.1	ZNF283 (directAnnotation).
PDCD10	hdpi__ZNF304	ZNF304 (directAnnotation).
PDCD10	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PDCD10	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PDCD10	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PDCD10	transfac_pro__M01199	TRIM28 (directAnnotation).
PDCD10	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PDCD10	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PDCD10	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PDCD10	transfac_pro__M03806	ZBTB7C (directAnnotation).
PDCD10	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PDCD10	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PDCD10	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
PDCD10	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PDCD10	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PDCD10	hdpi__TP73	TP73 (directAnnotation).
PDCD10	swissregulon__hs__ETV6	ETV6 (directAnnotation).
PDCD10	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PDCD10	cisbp__M02645	ETS1 (directAnnotation).
PDCD10	hdpi__ETV4	ETV4 (directAnnotation).
PDCD10	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
PDCD10	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
PDCD10	jaspar__MA1708.1	ETV7 (directAnnotation).
PDCD10	hdpi__FLI1	FLI1 (directAnnotation).
PDCD10	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PDCD10	transfac_pro__M04862	NRF1 (directAnnotation).
PDCD10	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
PDCD10	metacluster_182.10	ZFX (directAnnotation).
PDCD10	transfac_pro__M00492	STAT1 (directAnnotation).
PDCD10	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
PDCD10	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PDCD10	transfac_pro__M01973	PLAG1 (directAnnotation).
PDCD10	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP	ELK1; TBX21 (directAnnotation).
PDCD10	transfac_public__M00051	NFKB1 (directAnnotation).
PDCD10	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PDCD10	metacluster_143.13	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."