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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCNX1

Summary for PCNX1

Gene information	Gene symbol	PCNX1
	Ensembl ID	ENSG00000100731
	Entrez ID	22990
	Gene name	pecanex 1
	Synonyms	KIAA0805\|KIAA0995\|PCNX\|PCNXL1\|pecanex
	Gene type	protein_coding
	UniProtAcc	Q96RV3

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Dataset with differentially expressed gene: PCNX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.260779	1.08e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Fibroblasts	-0.621488	8.70e-03

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Expression of PCNX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCNX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCNX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCNX1	hsa-miR-561-3p	98.7756	NM_014982
PCNX1	hsa-miR-4282	98.5362	NM_014982
PCNX1	hsa-miR-4671-3p	98.2726	NM_014982
PCNX1	hsa-miR-182-5p	98.0242	NM_014982
PCNX1	hsa-miR-4422	97.338	NM_014982
PCNX1	hsa-miR-3646	97.1297	NM_014982
PCNX1	hsa-miR-670-3p	97.0894	NM_014982
PCNX1	hsa-miR-216a-3p	96.5928	NM_014982
PCNX1	hsa-miR-128-3p	96.5928	NM_014982
PCNX1	hsa-miR-5584-5p	96.2333	NM_014982
PCNX1	hsa-miR-4328	96.13	NM_014982
PCNX1	hsa-miR-5011-5p	95.7649	NM_014982
PCNX1	hsa-miR-6824-3p	95.689	NM_014982
PCNX1	hsa-miR-6764-3p	95.689	NM_014982
PCNX1	hsa-miR-3681-3p	95.34	NM_014982
PCNX1	hsa-miR-190a-3p	95.2482	NM_014982
PCNX1	hsa-miR-4778-3p	95.0378	NM_014982
PCNX1	hsa-miR-4470	94.9026	NM_014982
PCNX1	hsa-miR-1537-5p	94.867	NM_014982
PCNX1	hsa-miR-670-5p	94.5768	NM_014982
PCNX1	hsa-miR-27a-3p	94.2704	NM_014982
PCNX1	hsa-miR-27b-3p	94.2704	NM_014982
PCNX1	hsa-miR-9985	94.2704	NM_014982
PCNX1	hsa-miR-548e-5p	94.1507	NM_014982
PCNX1	hsa-miR-603	93.6483	NM_014982
PCNX1	hsa-miR-6830-5p	92.692	NM_014982
PCNX1	hsa-miR-3688-3p	92.5927	NM_014982
PCNX1	hsa-miR-4668-5p	92.4502	NM_014982
PCNX1	hsa-miR-548an	92.1218	NM_014982
PCNX1	hsa-miR-26b-5p	91.7898	NM_014982
PCNX1	hsa-miR-1297	91.7898	NM_014982
PCNX1	hsa-miR-26a-5p	91.7898	NM_014982
PCNX1	hsa-miR-12136	91.2917	NM_014982
PCNX1	hsa-miR-577	91.1844	NM_014982
PCNX1	hsa-miR-143-5p	91.1037	NM_014982
PCNX1	hsa-miR-410-3p	90.9423	NM_014982
PCNX1	hsa-miR-4465	90.6155	NM_014982
PCNX1	hsa-miR-539-5p	90.3741	NM_014982
PCNX1	hsa-miR-3148	90.1939	NM_014982
PCNX1	hsa-miR-651-3p	89.7483	NM_014982
PCNX1	hsa-miR-205-5p	89.2346	NM_014982
PCNX1	hsa-miR-5680	89.1656	NM_014982
PCNX1	hsa-miR-4649-3p	88.8604	NM_014982
PCNX1	hsa-miR-205-3p	88.7607	NM_014982
PCNX1	hsa-miR-186-5p	88.747	NM_014982
PCNX1	hsa-miR-454-3p	87.9918	NM_014982
PCNX1	hsa-miR-4266	87.4998	NM_014982
PCNX1	hsa-miR-383-5p	87.3959	NM_014982
PCNX1	hsa-miR-130b-5p	87.3494	NM_014982
PCNX1	hsa-miR-10401-5p	86.4119	NM_014982

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Motifs and transcription factors (TFs) regulating PCNX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCNX1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PCNX1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PCNX1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PCNX1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PCNX1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PCNX1	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
PCNX1	transfac_pro__M12686	ZBTB10 (directAnnotation).
PCNX1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PCNX1	metacluster_143.14	ZNF320 (directAnnotation).
PCNX1	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
PCNX1	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
PCNX1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PCNX1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
PCNX1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
PCNX1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PCNX1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PCNX1	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
PCNX1	transfac_pro__M04617	ZBTB7A (directAnnotation).
PCNX1	transfac_pro__M01973	PLAG1 (directAnnotation).
PCNX1	metacluster_151.2	ZNF23 (directAnnotation).
PCNX1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PCNX1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PCNX1	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
PCNX1	cisbp__M01864	EGR1 (inferredBy_Orthology).
PCNX1	tfdimers__MD00391	KLF4 (directAnnotation).
PCNX1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
PCNX1	transfac_pro__M05479	ZNF580 (directAnnotation).
PCNX1	tfdimers__MD00151	CHURC1 (directAnnotation).
PCNX1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PCNX1	cisbp__M00139	ZNF281 (inferredBy_Orthology).
PCNX1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
PCNX1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
PCNX1	transfac_public__M00491	PATZ1 (directAnnotation).
PCNX1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PCNX1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
PCNX1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PCNX1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PCNX1	transfac_pro__M01253	CNOT3 (directAnnotation).
PCNX1	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
PCNX1	cisbp__M00968	MTF2 (directAnnotation).
PCNX1	tfdimers__MD00038	TFAP2C (directAnnotation).
PCNX1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
PCNX1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PCNX1	transfac_pro__M01199	TRIM28 (directAnnotation).
PCNX1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
PCNX1	metacluster_3.14	WT1; WT1 (directAnnotation).
PCNX1	transfac_pro__M12697	ZNF142 (directAnnotation).
PCNX1	metacluster_84.2	RARA (directAnnotation).
PCNX1	transfac_pro__M01122	ZNF219 (directAnnotation).
PCNX1	transfac_pro__M07387	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."