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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCNP

Summary for PCNP

Gene information	Gene symbol	PCNP
	Ensembl ID	ENSG00000081154
	Entrez ID	57092
	Gene name	PEST proteolytic signal containing nuclear protein
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8WW12

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Dataset with differentially expressed gene: PCNP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.524278	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.558077	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.284481	1.87e-17
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.336422	2.94e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.403182	2.24e-28
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.27786	1.86e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.307878	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.250627	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.418297	1.72e-43

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Expression of PCNP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCNP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCNP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCNP	hsa-miR-4694-3p	96.8345	NM_001320401
PCNP	hsa-miR-365b-3p	96.5493	NM_001320395
PCNP	hsa-miR-365a-3p	96.5493	NM_001320395
PCNP	hsa-miR-4729	95.8288	NM_001320395
PCNP	hsa-miR-29a-5p	95.4853	NM_001320401
PCNP	hsa-miR-642a-5p	95.2812	NM_001320395
PCNP	hsa-miR-4653-3p	95.2227	NM_001320395
PCNP	hsa-miR-607	95.1967	NM_001320395
PCNP	hsa-miR-1283	94.6815	NM_001320395
PCNP	hsa-miR-651-3p	93.9737	NM_001320401
PCNP	hsa-miR-6892-3p	92.9039	NM_001320395
PCNP	hsa-miR-6509-5p	92.387	NM_001320401
PCNP	hsa-miR-6773-3p	91.9702	NM_001320401
PCNP	hsa-miR-12129	91.7379	NM_001320401
PCNP	hsa-miR-5696	91.6977	NM_001320395
PCNP	hsa-miR-3140-3p	91.6624	NM_001320401
PCNP	hsa-miR-4742-3p	91.5547	NM_001320401
PCNP	hsa-miR-519d-5p	91.2371	NM_001320395
PCNP	hsa-miR-3152-5p	89.7661	NM_001320401
PCNP	hsa-miR-6827-5p	89.0898	NM_001320395
PCNP	hsa-miR-4456	88.463	NM_001320401
PCNP	hsa-miR-539-3p	87.456	NM_001320395
PCNP	hsa-miR-485-3p	86.8711	NM_001320395
PCNP	hsa-miR-4511	86.6104	NM_001320401
PCNP	hsa-miR-1258	86.2855	NM_001320401
PCNP	hsa-miR-205-3p	86.2137	NM_001320401
PCNP	hsa-miR-514b-3p	86.2123	NM_001320395
PCNP	hsa-miR-514a-3p	86.2123	NM_001320395
PCNP	hsa-miR-3646	85.9099	NM_001320401
PCNP	hsa-miR-2276-5p	85.4993	NM_001320395
PCNP	hsa-miR-7110-3p	85.2186	NM_001320395
PCNP	hsa-miR-5688	84.6436	NM_001320401
PCNP	hsa-miR-4262	84.4785	NM_001320401
PCNP	hsa-miR-4666a-3p	84.2273	NM_001320401
PCNP	hsa-miR-3191-5p	83.6184	NM_001320401
PCNP	hsa-miR-3662	82.7984	NM_001320395
PCNP	hsa-miR-4699-3p	82.6023	NM_001320395
PCNP	hsa-miR-516b-3p	82.4726	NM_001320395
PCNP	hsa-miR-7162-5p	82.4726	NM_001320395
PCNP	hsa-miR-516a-3p	82.4726	NM_001320395
PCNP	hsa-miR-431-5p	82.4159	NM_001320395
PCNP	hsa-miR-6830-5p	82.2777	NM_001320401
PCNP	hsa-miR-338-5p	81.9031	NM_001320401
PCNP	hsa-miR-5093	81.8436	NM_001320395
PCNP	hsa-miR-6516-3p	81.5558	NM_001320401

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Motifs and transcription factors (TFs) regulating PCNP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCNP	metacluster_7.13	ZFX (directAnnotation).
PCNP	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PCNP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PCNP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PCNP	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PCNP	hdpi__ETV4	ETV4 (directAnnotation).
PCNP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PCNP	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PCNP	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PCNP	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
PCNP	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
PCNP	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PCNP	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PCNP	metacluster_161.2	LHX8 (directAnnotation).
PCNP	metacluster_161.4	LHX9 (directAnnotation).
PCNP	transfac_pro__M06292	ZNF766 (directAnnotation).
PCNP	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
PCNP	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
PCNP	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PCNP	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
PCNP	swissregulon__hs__ETV6	ETV6 (directAnnotation).
PCNP	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PCNP	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
PCNP	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
PCNP	metacluster_135.11	NR2C2 (directAnnotation).
PCNP	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PCNP	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PCNP	cisbp__M00341	PAX6 (directAnnotation).
PCNP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PCNP	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PCNP	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PCNP	cisbp__M00788	ZFY (inferredBy_Orthology).
PCNP	hdpi__ZNF304	ZNF304 (directAnnotation).
PCNP	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PCNP	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PCNP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PCNP	transfac_pro__M01199	TRIM28 (directAnnotation).
PCNP	metacluster_183.4	ETS1 (inferredBy_Orthology).
PCNP	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
PCNP	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PCNP	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
PCNP	transfac_pro__M01298	MECP2 (directAnnotation).
PCNP	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."