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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCMTD1

Summary for PCMTD1

Gene information	Gene symbol	PCMTD1
	Ensembl ID	ENSG00000168300
	Entrez ID	115294
	Gene name	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
	Synonyms	FLJ10883
	Gene type	protein_coding
	UniProtAcc	Q96MG8

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Dataset with differentially expressed gene: PCMTD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.41956	1.23e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.305396	2.91e-25
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.295167	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.364597	0.00e+00

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Expression of PCMTD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCMTD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCMTD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCMTD1	hsa-miR-153-5p	99.2244	NM_001286782
PCMTD1	hsa-miR-429	99.1148	NM_001286782
PCMTD1	hsa-miR-200c-3p	99.0775	NM_001286782
PCMTD1	hsa-miR-200b-3p	99.0775	NM_001286782
PCMTD1	hsa-miR-4282	98.8818	NM_001286782
PCMTD1	hsa-miR-3646	98.3331	NM_001286782
PCMTD1	hsa-miR-3163	97.6031	NM_001286782
PCMTD1	hsa-miR-4526	97.1661	NM_001286782
PCMTD1	hsa-miR-3660	97.1661	NM_001286782
PCMTD1	hsa-miR-9-3p	96.9626	NM_001286782
PCMTD1	hsa-miR-3662	96.6487	NM_001286782
PCMTD1	hsa-miR-1250-3p	96.2746	NM_001286782
PCMTD1	hsa-miR-7703	96.1393	NM_001286782
PCMTD1	hsa-miR-1277-5p	96.0574	NM_001286782
PCMTD1	hsa-miR-570-5p	94.5469	NM_001286782
PCMTD1	hsa-miR-548ai	94.5469	NM_001286782
PCMTD1	hsa-miR-548ag	94.5469	NM_001286782
PCMTD1	hsa-miR-548ba	94.5469	NM_001286782
PCMTD1	hsa-miR-577	93.0415	NM_001286782
PCMTD1	hsa-miR-320b	93.0322	NM_001286782
PCMTD1	hsa-miR-320d	93.0322	NM_001286782
PCMTD1	hsa-miR-4429	93.0322	NM_001286782
PCMTD1	hsa-miR-320a-3p	93.0322	NM_001286782
PCMTD1	hsa-miR-320c	93.0322	NM_001286782
PCMTD1	hsa-miR-20a-3p	92.8553	NM_001286782
PCMTD1	hsa-miR-4325	92.8095	NM_001286782
PCMTD1	hsa-miR-222-3p	92.6088	NM_001286782
PCMTD1	hsa-miR-221-3p	92.6088	NM_001286782
PCMTD1	hsa-miR-1976	92.4785	NM_001286782
PCMTD1	hsa-miR-6805-3p	91.9763	NM_001286782
PCMTD1	hsa-miR-5691	91.9763	NM_001286782
PCMTD1	hsa-miR-92b-3p	91.6695	NM_001286782
PCMTD1	hsa-miR-92a-3p	91.6695	NM_001286782
PCMTD1	hsa-miR-32-5p	91.6695	NM_001286782
PCMTD1	hsa-miR-4760-3p	91.5371	NM_001286782
PCMTD1	hsa-miR-1305	90.8987	NM_001286782
PCMTD1	hsa-miR-372-5p	90.7898	NM_001286782
PCMTD1	hsa-miR-335-3p	90.7853	NM_001286782
PCMTD1	hsa-miR-6806-5p	90.4395	NM_001286782
PCMTD1	hsa-miR-186-5p	90.3722	NM_001286782
PCMTD1	hsa-miR-182-5p	90.2955	NM_001286782
PCMTD1	hsa-miR-4803	89.7297	NM_001286782
PCMTD1	hsa-miR-181b-3p	89.3947	NM_001286782
PCMTD1	hsa-miR-181b-2-3p	89.3947	NM_001286782
PCMTD1	hsa-miR-4420	89.3947	NM_001286782
PCMTD1	hsa-miR-587	89.38	NM_001286782
PCMTD1	hsa-miR-363-3p	89.2862	NM_001286782
PCMTD1	hsa-miR-25-3p	89.2862	NM_001286782
PCMTD1	hsa-miR-367-3p	89.2862	NM_001286782
PCMTD1	hsa-miR-371a-5p	88.851	NM_001286782

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Motifs and transcription factors (TFs) regulating PCMTD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCMTD1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PCMTD1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
PCMTD1	transfac_pro__M04617	ZBTB7A (directAnnotation).
PCMTD1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PCMTD1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
PCMTD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PCMTD1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PCMTD1	transfac_pro__M07387	ZBTB7A (directAnnotation).
PCMTD1	transfac_pro__M07436	WT1 (directAnnotation).
PCMTD1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PCMTD1	transfac_pro__M00716	ZBTB14 (directAnnotation).
PCMTD1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PCMTD1	hdpi__HIP2	UBE2K (directAnnotation).
PCMTD1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PCMTD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PCMTD1	transfac_pro__M04893	TAF1 (directAnnotation).
PCMTD1	transfac_pro__M03876	ZBTB33 (directAnnotation).
PCMTD1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PCMTD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PCMTD1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PCMTD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PCMTD1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PCMTD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PCMTD1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PCMTD1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
PCMTD1	metacluster_7.13	ZFX (directAnnotation).
PCMTD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PCMTD1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PCMTD1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PCMTD1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PCMTD1	cisbp__M00249	WT1 (directAnnotation).
PCMTD1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PCMTD1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PCMTD1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PCMTD1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PCMTD1	transfac_pro__M01298	MECP2 (directAnnotation).
PCMTD1	transfac_pro__M01973	PLAG1 (directAnnotation).
PCMTD1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
PCMTD1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
PCMTD1	metacluster_143.13	ZBTB7A (directAnnotation).
PCMTD1	transfac_pro__M05845	ZSCAN29 (directAnnotation).
PCMTD1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
PCMTD1	transfac_pro__M02089	E2F3 (directAnnotation).
PCMTD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
PCMTD1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
PCMTD1	tfdimers__MD00483	ZBTB14 (directAnnotation).
PCMTD1	cisbp__M07938	E2F1 (directAnnotation).
PCMTD1	cisbp__M00968	MTF2 (directAnnotation).
PCMTD1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
PCMTD1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."