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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PCMT1

Summary for PCMT1

Gene information	Gene symbol	PCMT1
	Ensembl ID	ENSG00000120265
	Entrez ID	5110
	Gene name	protein-L-isoaspartate (D-aspartate) O-methyltransferase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PCMT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.255269	3.61e-32
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.389828	4.00e-30
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.43733	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.290484	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.307436	1.68e-44
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.58401	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.596437	1.57e-35
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.692194	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.630419	3.57e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.868715	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.388098	0.00e+00

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Expression of PCMT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCMT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCMT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCMT1	hsa-miR-195-5p	97.0156	NM_005389
PCMT1	hsa-miR-15a-5p	96.2325	NM_005389
PCMT1	hsa-miR-16-5p	96.2325	NM_005389
PCMT1	hsa-miR-6838-5p	96.2325	NM_005389
PCMT1	hsa-miR-15b-5p	96.2325	NM_005389
PCMT1	hsa-miR-4672	95.6121	NM_005389
PCMT1	hsa-miR-3911	95.2418	NM_001252053
PCMT1	hsa-miR-424-5p	94.9966	NM_005389
PCMT1	hsa-miR-497-5p	94.9966	NM_005389
PCMT1	hsa-miR-6862-5p	94.7189	NM_001252052
PCMT1	hsa-miR-4253	94.7189	NM_001252052
PCMT1	hsa-miR-6780b-3p	89.4432	NM_005389
PCMT1	hsa-miR-23b-3p	89.3477	NM_001252053
PCMT1	hsa-miR-23c	89.3477	NM_001252053
PCMT1	hsa-miR-23a-3p	89.3477	NM_001252053
PCMT1	hsa-miR-3190-3p	88.5952	NM_001252053
PCMT1	hsa-miR-4780	87.3491	NM_005389
PCMT1	hsa-miR-153-5p	86.6017	NM_001252053
PCMT1	hsa-miR-3941	86.4324	NM_005389
PCMT1	hsa-miR-6509-3p	85.3823	NM_005389
PCMT1	hsa-miR-466	84.0933	NM_005389
PCMT1	hsa-miR-3619-5p	83.6903	NM_005389
PCMT1	hsa-miR-761	83.6537	NM_005389
PCMT1	hsa-miR-214-3p	83.6537	NM_005389
PCMT1	hsa-miR-922	83.6537	NM_005389
PCMT1	hsa-miR-889-3p	82.3556	NM_001252052
PCMT1	hsa-miR-147a	82.2525	NM_001252053
PCMT1	hsa-miR-590-3p	82.1017	NM_001252052
PCMT1	hsa-miR-3691-3p	81.4495	NM_005389
PCMT1	hsa-miR-623	80.895	NM_005389
PCMT1	hsa-miR-1224-5p	80.7909	NM_001252052

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Motifs and transcription factors (TFs) regulating PCMT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCMT1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PCMT1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PCMT1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PCMT1	hdpi__TP73	TP73 (directAnnotation).
PCMT1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PCMT1	transfac_pro__M04826	EP300 (directAnnotation).
PCMT1	transfac_pro__M04950	EGR1 (directAnnotation).
PCMT1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
PCMT1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
PCMT1	jaspar__MA1933.1	SREBF2 (directAnnotation).
PCMT1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PCMT1	cisbp__M08198	ELF1 (directAnnotation).
PCMT1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PCMT1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
PCMT1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
PCMT1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PCMT1	transfac_pro__M06032	ZNF727 (directAnnotation).
PCMT1	transfac_pro__M06102	ZNF16 (directAnnotation).
PCMT1	hdpi__ELF2	ELF2 (directAnnotation).
PCMT1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
PCMT1	metacluster_183.4	ETS1 (inferredBy_Orthology).
PCMT1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PCMT1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PCMT1	"S-adenosyl-L-homocysteine"	DB01752	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."