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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCDHA12

Summary for PCDHA12

Gene information	Gene symbol	PCDHA12
	Ensembl ID	ENSG00000251664
	Entrez ID	56137
	Gene name	protocadherin alpha 12
	Synonyms	PCDH-ALPHA12
	Gene type	protein_coding
	UniProtAcc	Q9UN75

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Dataset with differentially expressed gene: PCDHA12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.631983	6.59e-03

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Expression of PCDHA12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCDHA12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCDHA12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCDHA12	hsa-miR-4753-3p	99.8097	NM_018903
PCDHA12	hsa-miR-6809-3p	99.4549	NM_018903
PCDHA12	hsa-miR-6871-5p	98.9017	NM_018903
PCDHA12	hsa-miR-130a-5p	98.2104	NM_018903
PCDHA12	hsa-miR-4306	97.2905	NM_018903
PCDHA12	hsa-miR-185-5p	96.113	NM_018903
PCDHA12	hsa-miR-4644	96.113	NM_018903
PCDHA12	hsa-miR-6731-5p	96.075	NM_018903
PCDHA12	hsa-miR-8085	96.075	NM_018903
PCDHA12	hsa-miR-4766-3p	96.0112	NM_018903
PCDHA12	hsa-miR-4262	95.1229	NM_018903
PCDHA12	hsa-miR-181d-5p	94.3489	NM_018903
PCDHA12	hsa-miR-181b-5p	94.3489	NM_018903
PCDHA12	hsa-miR-181a-5p	94.3489	NM_018903
PCDHA12	hsa-miR-181c-5p	94.3489	NM_018903
PCDHA12	hsa-miR-29a-3p	94.2031	NM_018903
PCDHA12	hsa-miR-29b-3p	94.2031	NM_018903
PCDHA12	hsa-miR-29c-3p	94.2031	NM_018903
PCDHA12	hsa-miR-3658	94.0407	NM_018903
PCDHA12	hsa-miR-4429	93.2554	NM_018903
PCDHA12	hsa-miR-320d	93.2554	NM_018903
PCDHA12	hsa-miR-320a-3p	93.2554	NM_018903
PCDHA12	hsa-miR-320c	93.2554	NM_018903
PCDHA12	hsa-miR-320b	93.2554	NM_018903
PCDHA12	hsa-miR-19a-3p	92.0995	NM_018903
PCDHA12	hsa-miR-19b-3p	92.0995	NM_018903
PCDHA12	hsa-miR-106a-5p	92.0872	NM_018903
PCDHA12	hsa-miR-548g-5p	91.5599	NM_018903
PCDHA12	hsa-miR-548x-5p	91.5599	NM_018903
PCDHA12	hsa-miR-548aj-5p	91.5599	NM_018903
PCDHA12	hsa-miR-548f-5p	91.5599	NM_018903
PCDHA12	hsa-miR-17-5p	91.1931	NM_018903
PCDHA12	hsa-miR-20a-5p	90.9737	NM_018903
PCDHA12	hsa-miR-106b-5p	90.9737	NM_018903
PCDHA12	hsa-miR-759	90.8017	NM_018903
PCDHA12	hsa-miR-4703-5p	90.4754	NM_018903
PCDHA12	hsa-miR-526b-3p	90.3783	NM_018903
PCDHA12	hsa-miR-6835-3p	90.3433	NM_018903
PCDHA12	hsa-miR-3942-5p	89.8822	NM_018903
PCDHA12	hsa-miR-6878-5p	89.5215	NM_018903
PCDHA12	hsa-miR-20b-5p	89.291	NM_018903
PCDHA12	hsa-miR-93-5p	89.291	NM_018903
PCDHA12	hsa-miR-519d-3p	89.291	NM_018903
PCDHA12	hsa-miR-3619-3p	88.8751	NM_018903
PCDHA12	hsa-miR-6824-5p	88.1444	NM_018903
PCDHA12	hsa-miR-767-3p	87.7479	NM_018903
PCDHA12	hsa-miR-194-3p	87.5614	NM_018903
PCDHA12	hsa-miR-5683	87.3895	NM_018903
PCDHA12	hsa-miR-6794-3p	87.2358	NM_018903
PCDHA12	hsa-miR-6799-3p	85.6302	NM_018903

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Motifs and transcription factors (TFs) regulating PCDHA12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."