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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCDH9

Summary for PCDH9

Gene information	Gene symbol	PCDH9
	Ensembl ID	ENSG00000184226
	Entrez ID	5101
	Gene name	protocadherin 9
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9HC56

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Dataset with differentially expressed gene: PCDH9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.356323	2.41e-08
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.324628	4.37e-15
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.389194	0.00e+00

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Expression of PCDH9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCDH9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCDH9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCDH9	hsa-miR-3529-3p	99.641	NM_001318372
PCDH9	hsa-miR-196a-1-3p	98.8202	NM_001318372
PCDH9	hsa-miR-7-2-3p	97.8657	NM_001318372
PCDH9	hsa-miR-7-1-3p	97.8657	NM_001318372
PCDH9	hsa-miR-3065-5p	97.7679	NM_001318372
PCDH9	hsa-miR-589-3p	97.6501	NM_001318372
PCDH9	hsa-miR-200a-3p	97.441	NM_001318372
PCDH9	hsa-miR-141-3p	97.441	NM_001318372
PCDH9	hsa-miR-7114-5p	97.2709	NM_001318372
PCDH9	hsa-miR-4318	97.1	NM_001318372
PCDH9	hsa-miR-5688	97.0381	NM_001318372
PCDH9	hsa-miR-548at-5p	96.8382	NM_001318372
PCDH9	hsa-miR-524-5p	96.829	NM_001318372
PCDH9	hsa-miR-520d-5p	96.829	NM_001318372
PCDH9	hsa-miR-3973	96.6787	NM_001318372
PCDH9	hsa-miR-7159-5p	96.3858	NM_001318372
PCDH9	hsa-miR-495-3p	95.8518	NM_001318372
PCDH9	hsa-miR-1305	94.0994	NM_001318372
PCDH9	hsa-miR-892a	93.8971	NM_001318372
PCDH9	hsa-miR-27a-3p	93.798	NM_001318374
PCDH9	hsa-miR-9985	93.798	NM_001318374
PCDH9	hsa-miR-27b-3p	93.798	NM_001318374
PCDH9	hsa-miR-4306	93.659	NM_001318372
PCDH9	hsa-miR-6800-5p	93.1495	NM_001318372
PCDH9	hsa-miR-2053	92.4861	NM_001318372
PCDH9	hsa-miR-4801	92.3681	NM_001318372
PCDH9	hsa-miR-3684	92.3531	NM_001318374
PCDH9	hsa-miR-4731-3p	91.5723	NM_001318372
PCDH9	hsa-miR-153-5p	91.4397	NM_001318372
PCDH9	hsa-miR-4782-5p	91.3885	NM_001318374
PCDH9	hsa-miR-5706	91.3885	NM_001318374
PCDH9	hsa-miR-4738-3p	91.2807	NM_001318372
PCDH9	hsa-miR-7161-5p	91.1909	NM_001318372
PCDH9	hsa-miR-507	90.9827	NM_001318372
PCDH9	hsa-miR-3160-3p	90.8333	NM_001318372
PCDH9	hsa-miR-3201	90.7073	NM_001318372
PCDH9	hsa-miR-6833-5p	90.6849	NM_001318372
PCDH9	hsa-miR-510-3p	90.5409	NM_001318372
PCDH9	hsa-miR-4644	90.5392	NM_001318372
PCDH9	hsa-miR-185-5p	90.5392	NM_001318372
PCDH9	hsa-miR-4427	90.388	NM_001318372
PCDH9	hsa-miR-4791	90.033	NM_001318372
PCDH9	hsa-miR-4666b	89.9433	NM_001318372
PCDH9	hsa-miR-1297	89.7528	NM_001318372
PCDH9	hsa-miR-4755-3p	89.749	NM_001318372
PCDH9	hsa-miR-4699-3p	89.4357	NM_001318372
PCDH9	hsa-miR-5011-3p	89.3894	NM_001318372
PCDH9	hsa-miR-5192	89.2516	NM_001318372
PCDH9	hsa-miR-16-5p	89.1703	NM_001318372
PCDH9	hsa-miR-15b-5p	89.1703	NM_001318372

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Motifs and transcription factors (TFs) regulating PCDH9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCDH9	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PCDH9	metacluster_3.10	KLF2; KLF4 (directAnnotation).
PCDH9	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
PCDH9	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
PCDH9	transfac_pro__M01783	SP2 (directAnnotation).
PCDH9	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PCDH9	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PCDH9	cisbp__M00341	PAX6 (directAnnotation).
PCDH9	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PCDH9	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
PCDH9	transfac_pro__M01253	CNOT3 (directAnnotation).
PCDH9	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PCDH9	metacluster_7.13	ZFX (directAnnotation).
PCDH9	cisbp__M00968	MTF2 (directAnnotation).
PCDH9	transfac_pro__M04817	ZBTB33 (directAnnotation).
PCDH9	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PCDH9	transfac_pro__M02089	E2F3 (directAnnotation).
PCDH9	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PCDH9	jaspar__MA0748.2	YY2 (directAnnotation).
PCDH9	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
PCDH9	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
PCDH9	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PCDH9	taipale_tf_pairs__GCM2_DLX2_RTRCGGGNNNNNTAATTR_CAP_repr	DLX2; GCM2 (directAnnotation).
PCDH9	taipale_tf_pairs__GCM1_ETV7_NTRNGGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
PCDH9	transfac_pro__M05860	ZNF548 (directAnnotation).
PCDH9	jaspar__MA1983.1	ZNF582 (directAnnotation).
PCDH9	transfac_pro__M06259	ZNF91 (directAnnotation).
PCDH9	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
PCDH9	hocomoco__ZBT14_HUMAN.H11MO.0.C	ZBTB14 (directAnnotation).
PCDH9	taipale_tf_pairs__GCM1_FOXI1_TGTTGANGCGGGN_CAP	FOXI1; GCM1 (directAnnotation).
PCDH9	hdpi__TP73	TP73 (directAnnotation).
PCDH9	tfdimers__MD00483	ZBTB14 (directAnnotation).
PCDH9	transfac_pro__M06054	ZNF99 (directAnnotation).
PCDH9	transfac_pro__M06071	ZNF814 (directAnnotation).
PCDH9	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
PCDH9	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
PCDH9	metacluster_43.2	MESP2; MSC; NEUROD1; NEUROG2; TWIST1; ZBTB18; ZBTB18; ZBTB18; ZBTB18; ZBTB42; ZBTB42 (directAnnotation). ATOH1; ATOH1; NEUROD2; PTF1A (inferredBy_Orthology).
PCDH9	metacluster_45.4	E2F2 (directAnnotation).
PCDH9	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
PCDH9	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
PCDH9	transfac_pro__M04916	TAF1 (directAnnotation).
PCDH9	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PCDH9	transfac_pro__M05617	ZNF500 (directAnnotation).
PCDH9	hdpi__HTATIP2	HTATIP2 (directAnnotation).
PCDH9	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
PCDH9	hdpi__NRL	NRL (directAnnotation).
PCDH9	taipale_tf_pairs__E2F1_NHLH1_SGCGCCNNNNNNNNNNNNCAGCTGNN_CAP_repr	E2F1; NHLH1 (directAnnotation).
PCDH9	transfac_pro__M01269	NR4A2 (directAnnotation).
PCDH9	transfac_pro__M01199	TRIM28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."