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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCDH7

Summary for PCDH7

Gene information	Gene symbol	PCDH7
	Ensembl ID	ENSG00000169851
	Entrez ID	5099
	Gene name	protocadherin 7
	Synonyms	BH-Pcdh\|PPP1R120
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PCDH7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.362935	6.12e-26
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.479899	7.98e-35
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.363266	1.27e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.330205	0.00e+00

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Expression of PCDH7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCDH7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCDH7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCDH7	hsa-miR-491-3p	98.8832	NM_001173523
PCDH7	hsa-miR-4766-5p	98.5781	NM_001173523
PCDH7	hsa-miR-655-3p	96.8384	NM_032457
PCDH7	hsa-miR-374c-5p	96.8384	NM_032457
PCDH7	hsa-miR-4693-5p	96.3716	NM_001173523
PCDH7	hsa-miR-600	95.9866	NM_001173523
PCDH7	hsa-miR-1277-5p	95.7837	NM_032457
PCDH7	hsa-miR-190a-3p	95.6008	NM_001173523
PCDH7	hsa-miR-670-5p	95.1342	NM_001173523
PCDH7	hsa-miR-101-3p	94.3673	NM_001173523
PCDH7	hsa-miR-92a-3p	94.1515	NM_001173523
PCDH7	hsa-miR-32-5p	94.1515	NM_001173523
PCDH7	hsa-miR-92b-3p	94.1515	NM_001173523
PCDH7	hsa-miR-589-3p	94.1051	NM_001173523
PCDH7	hsa-miR-3680-3p	94.0697	NM_001173523
PCDH7	hsa-miR-7156-5p	93.9008	NM_032457
PCDH7	hsa-miR-548ar-3p	93.8681	NM_032457
PCDH7	hsa-miR-6885-3p	93.8055	NM_001173523
PCDH7	hsa-miR-4795-3p	93.5825	NM_001173523
PCDH7	hsa-miR-4275	93.5549	NM_001173523
PCDH7	hsa-miR-548az-3p	93.4137	NM_032457
PCDH7	hsa-miR-196a-1-3p	93.2224	NM_032457
PCDH7	hsa-miR-1290	92.48	NM_002589
PCDH7	hsa-miR-4760-5p	92.118	NM_002589
PCDH7	hsa-miR-3658	92.0875	NM_001173523
PCDH7	hsa-miR-6818-3p	91.6464	NM_001173523
PCDH7	hsa-miR-4432	91.6169	NM_002589
PCDH7	hsa-miR-9-5p	91.4182	NM_001173523
PCDH7	hsa-miR-363-3p	91.1258	NM_001173523
PCDH7	hsa-miR-367-3p	91.1258	NM_001173523
PCDH7	hsa-miR-25-3p	91.1258	NM_001173523
PCDH7	hsa-miR-548e-3p	91.1051	NM_032457
PCDH7	hsa-miR-548bc	91.1051	NM_032457
PCDH7	hsa-miR-548a-3p	91.1051	NM_032457
PCDH7	hsa-miR-548f-3p	91.1051	NM_032457
PCDH7	hsa-miR-9-3p	90.7158	NM_001173523
PCDH7	hsa-miR-4273	90.604	NM_032457
PCDH7	hsa-miR-520h	90.3728	NM_032457
PCDH7	hsa-miR-520g-3p	90.3728	NM_032457
PCDH7	hsa-miR-5004-3p	90.2701	NM_002589
PCDH7	hsa-miR-656-3p	90.1522	NM_001173523
PCDH7	hsa-miR-144-3p	89.6017	NM_001173523
PCDH7	hsa-miR-3662	89.5989	NM_032457
PCDH7	hsa-miR-323a-3p	89.5915	NM_001173523
PCDH7	hsa-miR-4319	89.1406	NM_001173523
PCDH7	hsa-miR-548g-3p	89.0201	NM_032457
PCDH7	hsa-miR-607	88.8896	NM_032457
PCDH7	hsa-miR-3143	88.7548	NM_001173523
PCDH7	hsa-miR-7152-3p	88.684	NM_001173523
PCDH7	hsa-miR-5692a	88.3795	NM_001173523

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Motifs and transcription factors (TFs) regulating PCDH7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCDH7	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
PCDH7	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PCDH7	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
PCDH7	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
PCDH7	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
PCDH7	hdpi__TP73	TP73 (directAnnotation).
PCDH7	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
PCDH7	jaspar__MA1957.1	ELK1 (directAnnotation).
PCDH7	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
PCDH7	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
PCDH7	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
PCDH7	transfac_pro__M05770	ZNF77 (directAnnotation).
PCDH7	transfac_pro__M06602	ZNF669 (directAnnotation).
PCDH7	jaspar__MA0079.5	SP1 (directAnnotation).
PCDH7	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
PCDH7	hdpi__NFIX	NFIX (directAnnotation).
PCDH7	cisbp__M07938	E2F1 (directAnnotation).
PCDH7	transfac_pro__M07260	IKZF1 (directAnnotation).
PCDH7	transfac_pro__M01835	KLF4 (directAnnotation).
PCDH7	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
PCDH7	swissregulon__hs__MTA3	MTA3 (directAnnotation).
PCDH7	transfac_pro__M07270	TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."