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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCBP2

Summary for PCBP2

Gene information	Gene symbol	PCBP2
	Ensembl ID	ENSG00000197111
	Entrez ID	5094
	Gene name	poly(rC) binding protein 2
	Synonyms	hnRNP-E2\|HNRNPE2\|HNRPE2
	Gene type	protein_coding
	UniProtAcc	Q15366

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Dataset with differentially expressed gene: PCBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Progenitors	0.558041	1.38e-04
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.336028	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	-0.287899	1.32e-25
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	0.578039	1.51e-10
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.521537	3.45e-29
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.411742	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.323865	1.00e-24
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.400071	6.80e-24
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.259029	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.374452	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.29772	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.442183	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.26551	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.98181	1.25e-05
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.280536	3.76e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.30558	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.267255	0.00e+00

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Expression of PCBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCBP2	hsa-miR-190a-3p	99.9964	NM_001098620
PCBP2	hsa-miR-5011-5p	99.981	NM_001098620
PCBP2	hsa-miR-6807-5p	97.5056	NM_001098620
PCBP2	hsa-miR-548as-3p	93.6703	NM_001098620
PCBP2	hsa-miR-4775	93.4227	NM_031989
PCBP2	hsa-miR-4738-3p	92.9648	NM_031989
PCBP2	hsa-miR-5681a	92.2696	NM_031989
PCBP2	hsa-miR-4499	91.9506	NM_001098620
PCBP2	hsa-miR-378a-5p	89.5716	NM_031989
PCBP2	hsa-miR-421	88.0259	NM_031989
PCBP2	hsa-miR-548aa	87.2916	NM_001098620
PCBP2	hsa-miR-548t-3p	87.2916	NM_001098620
PCBP2	hsa-miR-548ap-3p	87.2916	NM_001098620
PCBP2	hsa-miR-4482-3p	86.6791	NM_001098620
PCBP2	hsa-miR-6777-3p	85.7657	NM_031989
PCBP2	hsa-miR-3163	85.4827	NM_001098620
PCBP2	hsa-miR-5582-3p	85.313	NM_001098620
PCBP2	hsa-miR-548ar-3p	85.313	NM_001098620
PCBP2	hsa-miR-539-5p	84.8831	NM_031989
PCBP2	hsa-miR-520d-5p	84.8778	NM_001098620
PCBP2	hsa-miR-524-5p	84.8778	NM_001098620
PCBP2	hsa-miR-1293	82.7627	NM_031989
PCBP2	hsa-miR-3691-5p	82.5932	NM_031989
PCBP2	hsa-miR-3134	82.5252	NM_001098620
PCBP2	hsa-miR-548ay-3p	82.3731	NM_001098620
PCBP2	hsa-miR-548at-3p	82.3731	NM_001098620
PCBP2	hsa-miR-3613-3p	82.1656	NM_031989
PCBP2	hsa-miR-4483	81.9557	NM_031989
PCBP2	hsa-miR-548c-3p	81.7098	NM_001098620
PCBP2	hsa-miR-6744-5p	81.1286	NM_031989
PCBP2	hsa-miR-3919	81.0848	NM_031989
PCBP2	hsa-miR-548f-3p	81.0507	NM_001098620
PCBP2	hsa-miR-548a-3p	81.0507	NM_001098620
PCBP2	hsa-miR-548az-3p	81.0507	NM_001098620
PCBP2	hsa-miR-548bc	81.0507	NM_001098620
PCBP2	hsa-miR-548e-3p	81.0507	NM_001098620
PCBP2	hsa-miR-6825-3p	80.6484	NM_031989
PCBP2	hsa-miR-5093	80.1761	NM_031989

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Motifs and transcription factors (TFs) regulating PCBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCBP2	metacluster_7.13	ZFX (directAnnotation).
PCBP2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PCBP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PCBP2	jaspar__MA0079.5	SP1 (directAnnotation).
PCBP2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
PCBP2	metacluster_112.5	HOXA4; PAX3; PAX7; PAX7 (directAnnotation).
PCBP2	jaspar__MA0748.2	YY2 (directAnnotation).
PCBP2	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
PCBP2	transfac_pro__M00652	NRF1 (directAnnotation).
PCBP2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PCBP2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
PCBP2	hdpi__TIMELESS	TIMELESS (directAnnotation).
PCBP2	transfac_pro__M05893	ZNF676 (directAnnotation).
PCBP2	taipale_tf_pairs__E2F1_EOMES_RGGTGTNNNGGCGSNNTNNCRSNN_CAP	E2F1; EOMES (directAnnotation).
PCBP2	metacluster_44.18	NKX3-2 (directAnnotation).
PCBP2	metacluster_44.21	NKX3-2 (directAnnotation).
PCBP2	metacluster_44.13	NKX3-1; NKX3-2 (directAnnotation).
PCBP2	tfdimers__MD00187	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
PCBP2	transfac_pro__M06292	ZNF766 (directAnnotation).
PCBP2	metacluster_44.19	NKX3-1 (inferredBy_Orthology).
PCBP2	metacluster_44.16	NKX3-1 (directAnnotation).
PCBP2	swissregulon__mm__Sox5	SOX5 (inferredBy_Orthology).
PCBP2	tfdimers__MD00084	ARID3A; NKX2-4 (directAnnotation).
PCBP2	metacluster_190.3	IKZF2; IKZF2; ILF2; NFATC1; NFATC2; NFATC3; NFATC4 (directAnnotation). NFATC2 (inferredBy_Orthology).
PCBP2	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
PCBP2	hdpi__POU4F3	POU4F3 (directAnnotation).
PCBP2	cisbp__M11350	STAT1 (directAnnotation).
PCBP2	transfac_pro__M07607	NFATC3 (directAnnotation).
PCBP2	tfdimers__MD00548	CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; MYCN (directAnnotation).
PCBP2	transfac_pro__M06137	ZNF250 (directAnnotation).
PCBP2	transfac_pro__M06119	ZNF254 (directAnnotation).
PCBP2	transfac_pro__M04844	MAX (directAnnotation).
PCBP2	metacluster_44.25	ISL2 (directAnnotation).
PCBP2	transfac_pro__M05976	ZNF223 (directAnnotation).
PCBP2	tfdimers__MD00335	FOXP3; NKX2-1 (directAnnotation).
PCBP2	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
PCBP2	transfac_pro__M06919	ZNF652 (directAnnotation).
PCBP2	transfac_pro__M06270	ZNF468 (directAnnotation).
PCBP2	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
PCBP2	hdpi__MAGED4	MAGED4 (directAnnotation).
PCBP2	transfac_pro__M06877	ZNF224 (directAnnotation).
PCBP2	hdpi__TSNAX	TSNAX (directAnnotation).
PCBP2	cisbp__M00788	ZFY (inferredBy_Orthology).
PCBP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PCBP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PCBP2	transfac_pro__M02898	SMAD3 (directAnnotation).
PCBP2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PCBP2	cisbp__M00249	WT1 (directAnnotation).
PCBP2	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
PCBP2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."