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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PCBP1

Summary for PCBP1

Gene information	Gene symbol	PCBP1
	Ensembl ID	ENSG00000169564
	Entrez ID	5093
	Gene name	poly(rC) binding protein 1
	Synonyms	hnRNP-E1\|hnRNP-X\|HNRPE1\|HNRPX
	Gene type	protein_coding
	UniProtAcc	Q15365

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Dataset with differentially expressed gene: PCBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.645309	1.27e-24
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Progenitors	0.651123	4.84e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.27144	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.454605	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.425268	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.270206	2.94e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.449741	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.522843	7.36e-19
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.428589	2.44e-27
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.39365	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.510198	2.24e-14
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	-0.382125	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.438637	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.418795	5.04e-26
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.253673	4.67e-04
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	-0.254211	3.69e-29
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.32229	1.72e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.250375	6.13e-27
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.347803	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.500169	7.88e-35
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.562251	1.13e-28
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.250616	5.16e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.280202	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.474124	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.04561	7.15e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.400973	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.27006	1.19e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.366091	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.36039	7.05e-23
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.309649	1.65e-19
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.274246	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	1.15836	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.761915	0.00e+00

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Expression of PCBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PCBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PCBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PCBP1	hsa-miR-7977	98.0099	NM_006196
PCBP1	hsa-miR-4672	95.2753	NM_006196
PCBP1	hsa-miR-548as-3p	92.9759	NM_006196
PCBP1	hsa-miR-619-3p	92.7166	NM_006196
PCBP1	hsa-miR-5582-3p	91.2338	NM_006196
PCBP1	hsa-miR-548ar-3p	91.2338	NM_006196
PCBP1	hsa-miR-922	90.8707	NM_006196
PCBP1	hsa-miR-6777-3p	88.9219	NM_006196
PCBP1	hsa-miR-490-3p	88.7083	NM_006196
PCBP1	hsa-miR-3163	88.5592	NM_006196
PCBP1	hsa-miR-3941	88.5055	NM_006196
PCBP1	hsa-miR-607	88.465	NM_006196
PCBP1	hsa-miR-335-3p	88.2771	NM_006196
PCBP1	hsa-miR-548bc	88.0617	NM_006196
PCBP1	hsa-miR-548az-3p	88.0617	NM_006196
PCBP1	hsa-miR-548a-3p	88.0617	NM_006196
PCBP1	hsa-miR-548e-3p	88.0617	NM_006196
PCBP1	hsa-miR-548f-3p	88.0617	NM_006196
PCBP1	hsa-miR-466	85.8491	NM_006196
PCBP1	hsa-miR-10a-3p	82.87	NM_006196
PCBP1	hsa-miR-6807-5p	80.8775	NM_006196
PCBP1	hsa-miR-8070	80.1039	NM_006196

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Motifs and transcription factors (TFs) regulating PCBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PCBP1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
PCBP1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
PCBP1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
PCBP1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PCBP1	transfac_pro__M04950	EGR1 (directAnnotation).
PCBP1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
PCBP1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PCBP1	cisbp__M08198	ELF1 (directAnnotation).
PCBP1	transfac_pro__M00652	NRF1 (directAnnotation).
PCBP1	hdpi__ETV4	ETV4 (directAnnotation).
PCBP1	transfac_pro__M04866	HDAC2 (directAnnotation).
PCBP1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PCBP1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
PCBP1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
PCBP1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
PCBP1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PCBP1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
PCBP1	metacluster_141.4	GLIS2 (directAnnotation).
PCBP1	jaspar__MA0748.2	YY2 (directAnnotation).
PCBP1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
PCBP1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
PCBP1	hdpi__EBF1	EBF1 (directAnnotation).
PCBP1	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
PCBP1	transfac_pro__M06259	ZNF91 (directAnnotation).
PCBP1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
PCBP1	transfac_pro__M06340	ZNF790 (directAnnotation).
PCBP1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
PCBP1	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
PCBP1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PCBP1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PCBP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PCBP1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PCBP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PCBP1	metacluster_151.2	ZNF23 (directAnnotation).
PCBP1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PCBP1	transfac_pro__M01199	TRIM28 (directAnnotation).
PCBP1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PCBP1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PCBP1	transfac_pro__M01253	CNOT3 (directAnnotation).
PCBP1	cisbp__M00968	MTF2 (directAnnotation).
PCBP1	metacluster_7.13	ZFX (directAnnotation).
PCBP1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PCBP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PCBP1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PCBP1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
PCBP1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PCBP1	transfac_pro__M07310	SP5 (directAnnotation).
PCBP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PCBP1	transfac_pro__M04893	TAF1 (directAnnotation).
PCBP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."