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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PBX2

Summary for PBX2

Gene information	Gene symbol	PBX2
	Ensembl ID	ENSG00000236353
	Entrez ID	5089
	Gene name	PBX homeobox 2
	Synonyms	G17\|HOX12\|PBX2MHC
	Gene type	protein_coding
	UniProtAcc	P40425

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Dataset with differentially expressed gene: PBX2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.320675	3.99e-17
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.377839	2.33e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.293889	0.00e+00

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Expression of PBX2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PBX2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PBX2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PBX2	hsa-miR-4251	99.2	NM_002586
PBX2	hsa-miR-3529-3p	97.6539	NM_002586
PBX2	hsa-miR-6852-3p	97.303	NM_002586
PBX2	hsa-miR-3150b-3p	95.9229	NM_002586
PBX2	hsa-miR-4784	95.9229	NM_002586
PBX2	hsa-miR-548av-3p	95.7855	NM_002586
PBX2	hsa-miR-3909	95.1471	NM_002586
PBX2	hsa-miR-4500	94.7444	NM_002586
PBX2	hsa-miR-4426	94.636	NM_002586
PBX2	hsa-miR-182-5p	94.1679	NM_002586
PBX2	hsa-miR-6733-5p	93.6703	NM_002586
PBX2	hsa-miR-6739-5p	93.6703	NM_002586
PBX2	hsa-miR-6867-5p	93.5199	NM_002586
PBX2	hsa-miR-4306	93.4463	NM_002586
PBX2	hsa-miR-1200	93.2919	NM_002586
PBX2	hsa-miR-3153	92.2901	NM_002586
PBX2	hsa-miR-4271	92.0245	NM_002586
PBX2	hsa-miR-98-5p	91.9339	NM_002586
PBX2	hsa-let-7c-5p	91.9339	NM_002586
PBX2	hsa-let-7a-5p	91.9339	NM_002586
PBX2	hsa-let-7g-5p	91.9339	NM_002586
PBX2	hsa-let-7b-5p	91.9339	NM_002586
PBX2	hsa-let-7f-5p	91.9339	NM_002586
PBX2	hsa-let-7e-5p	91.9339	NM_002586
PBX2	hsa-let-7i-5p	91.9339	NM_002586
PBX2	hsa-miR-92a-2-5p	91.5347	NM_002586
PBX2	hsa-miR-4662b	91.5247	NM_002586
PBX2	hsa-miR-4647	91.4891	NM_002586
PBX2	hsa-miR-4504	91.4037	NM_002586
PBX2	hsa-miR-302c-5p	91.2932	NM_002586
PBX2	hsa-miR-4642	91.2177	NM_002586
PBX2	hsa-miR-6780b-5p	90.8571	NM_002586
PBX2	hsa-miR-4725-3p	90.8571	NM_002586
PBX2	hsa-miR-4458	90.0933	NM_002586
PBX2	hsa-let-7d-5p	90.0933	NM_002586
PBX2	hsa-miR-185-5p	89.5679	NM_002586
PBX2	hsa-miR-4644	89.5679	NM_002586
PBX2	hsa-miR-548ar-3p	88.9201	NM_002586
PBX2	hsa-miR-558	88.6116	NM_002586
PBX2	hsa-miR-4668-5p	87.6461	NM_002586
PBX2	hsa-miR-2110	86.8899	NM_002586
PBX2	hsa-miR-6785-5p	86.4653	NM_002586
PBX2	hsa-miR-4728-5p	86.4653	NM_002586
PBX2	hsa-miR-548e-3p	86.2488	NM_002586
PBX2	hsa-miR-548az-3p	86.2488	NM_002586
PBX2	hsa-miR-548a-3p	86.2488	NM_002586
PBX2	hsa-miR-548f-3p	86.2488	NM_002586
PBX2	hsa-miR-548bc	86.2488	NM_002586
PBX2	hsa-miR-6766-5p	86.228	NM_002586
PBX2	hsa-miR-6756-5p	86.228	NM_002586

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Motifs and transcription factors (TFs) regulating PBX2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PBX2	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).
PBX2	taipale_cyt_meth__LBX2_CTCGTTAN_eDBD	LBX2 (directAnnotation).
PBX2	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_HT	HOXB13; ONECUT2 (directAnnotation).
PBX2	jaspar__MA1948.1	ETV5 (directAnnotation).
PBX2	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
PBX2	jaspar__MA1954.1	FOXO1 (directAnnotation).
PBX2	transfac_pro__M04887	TCF12 (directAnnotation).
PBX2	kznf__SP1_Transfac.3_Transfac	SP1 (directAnnotation).
PBX2	transfac_pro__M06372	ZNF841 (directAnnotation).
PBX2	jaspar__MA1946.1	FOXI1 (directAnnotation).
PBX2	jaspar__MA1955.1	FOXO1 (directAnnotation).
PBX2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."