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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PBRM1

Summary for PBRM1

Gene information	Gene symbol	PBRM1
	Ensembl ID	ENSG00000163939
	Entrez ID	55193
	Gene name	polybromo 1
	Synonyms	BAF180\|PB1\|SMARCH1
	Gene type	protein_coding
	UniProtAcc	Q86U86

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Dataset with differentially expressed gene: PBRM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.383542	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.315363	1.10e-39
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.447884	0.00e+00

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Expression of PBRM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PBRM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PBRM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PBRM1	hsa-miR-5011-5p	99.961	NM_018313
PBRM1	hsa-miR-190a-3p	99.7429	NM_018313
PBRM1	hsa-miR-5688	98.3816	NM_018313
PBRM1	hsa-miR-495-3p	97.9111	NM_018313
PBRM1	hsa-miR-570-3p	97.0783	NM_018313
PBRM1	hsa-miR-590-5p	96.3517	NM_018313
PBRM1	hsa-miR-21-5p	95.6534	NM_018313
PBRM1	hsa-miR-410-3p	95.0816	NM_018313
PBRM1	hsa-miR-5582-3p	93.5214	NM_018313
PBRM1	hsa-miR-548c-3p	92.8357	NM_018313
PBRM1	hsa-miR-4738-3p	92.7658	NM_018313
PBRM1	hsa-miR-335-3p	92.5126	NM_018313
PBRM1	hsa-miR-5009-3p	92.0586	NM_018313
PBRM1	hsa-miR-563	91.6756	NM_018313
PBRM1	hsa-miR-380-5p	91.3413	NM_018313
PBRM1	hsa-miR-6867-5p	91.3161	NM_018313
PBRM1	hsa-miR-6739-3p	91.2187	NM_018313
PBRM1	hsa-miR-548an	91.1593	NM_018313
PBRM1	hsa-miR-223-5p	89.7208	NM_018313
PBRM1	hsa-miR-195-3p	88.7999	NM_018313
PBRM1	hsa-miR-16-2-3p	88.7999	NM_018313
PBRM1	hsa-miR-5692a	88.6818	NM_018313
PBRM1	hsa-miR-5579-3p	88.5821	NM_018313
PBRM1	hsa-miR-3529-3p	88.2007	NM_018313
PBRM1	hsa-miR-4528	88.1387	NM_018313
PBRM1	hsa-miR-450b-5p	87.6956	NM_018313
PBRM1	hsa-miR-3163	87.4413	NM_018313
PBRM1	hsa-miR-5004-3p	87.3733	NM_018313
PBRM1	hsa-miR-3613-3p	86.6718	NM_018313
PBRM1	hsa-miR-196a-3p	85.8815	NM_018313
PBRM1	hsa-miR-651-3p	85.5736	NM_018313
PBRM1	hsa-miR-548l	85.0052	NM_018313
PBRM1	hsa-miR-548t-5p	84.4646	NM_018313
PBRM1	hsa-miR-548az-5p	84.4646	NM_018313
PBRM1	hsa-miR-4282	84.0624	NM_018313
PBRM1	hsa-miR-452-3p	84.0239	NM_018313
PBRM1	hsa-miR-548as-3p	83.2896	NM_018313
PBRM1	hsa-miR-5704	83.1938	NM_018313
PBRM1	hsa-miR-196a-1-3p	82.3781	NM_018313
PBRM1	hsa-miR-6835-3p	82.3153	NM_018313
PBRM1	hsa-miR-3662	82.2924	NM_018313
PBRM1	hsa-miR-6768-3p	81.8975	NM_018313
PBRM1	hsa-miR-548aw	81.4103	NM_018313

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Motifs and transcription factors (TFs) regulating PBRM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PBRM1	metacluster_7.13	ZFX (directAnnotation).
PBRM1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PBRM1	metacluster_151.2	ZNF23 (directAnnotation).
PBRM1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PBRM1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PBRM1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PBRM1	hdpi__ETV4	ETV4 (directAnnotation).
PBRM1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PBRM1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PBRM1	jaspar__MA0079.5	SP1 (directAnnotation).
PBRM1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
PBRM1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PBRM1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PBRM1	transfac_pro__M01175	ZBTB7B (directAnnotation).
PBRM1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PBRM1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PBRM1	transfac_pro__M02090	E2F4 (directAnnotation).
PBRM1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PBRM1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PBRM1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PBRM1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PBRM1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."