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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PATJ

Summary for PATJ

Gene information	Gene symbol	PATJ
	Ensembl ID	ENSG00000132849
	Entrez ID	10207
	Gene name	PATJ crumbs cell polarity complex component
	Synonyms	Cipp\|INADL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PATJ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.386137	8.51e-43

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Expression of PATJ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PATJ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PATJ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PATJ	hsa-miR-373-5p	98.448	NM_176877
PATJ	hsa-miR-371b-5p	98.448	NM_176877
PATJ	hsa-miR-616-5p	98.448	NM_176877
PATJ	hsa-miR-4735-3p	97.4004	NM_176877
PATJ	hsa-miR-18a-5p	97.1828	NM_176877
PATJ	hsa-miR-18b-5p	97.1828	NM_176877
PATJ	hsa-miR-6892-3p	92.7423	NM_176877
PATJ	hsa-miR-6847-3p	92.0779	NM_176877
PATJ	hsa-miR-1323	91.6119	NM_176877
PATJ	hsa-miR-664b-3p	91.2928	NM_176877
PATJ	hsa-miR-579-3p	91.2928	NM_176877
PATJ	hsa-miR-4698	91.2392	NM_176877
PATJ	hsa-miR-548o-3p	91.0586	NM_176877
PATJ	hsa-miR-1305	90.6124	NM_176877
PATJ	hsa-miR-4649-3p	89.4142	NM_176877
PATJ	hsa-miR-12119	88.1763	NM_176877
PATJ	hsa-miR-4291	87.1696	NM_176877
PATJ	hsa-miR-4325	86.0609	NM_176877
PATJ	hsa-miR-3136-3p	84.32	NM_176877
PATJ	hsa-miR-7155-3p	84.32	NM_176877
PATJ	hsa-miR-223-5p	84.1168	NM_176877
PATJ	hsa-miR-5700	84.0045	NM_176877
PATJ	hsa-miR-511-3p	83.2363	NM_176877
PATJ	hsa-miR-4693-5p	82.5924	NM_176877
PATJ	hsa-miR-155-5p	81.7343	NM_176877
PATJ	hsa-miR-5692a	81.133	NM_176877
PATJ	hsa-miR-589-3p	80.7442	NM_176877
PATJ	hsa-miR-8070	80.3759	NM_176877

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Motifs and transcription factors (TFs) regulating PATJ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PATJ	metacluster_135.11	NR2C2 (directAnnotation).
PATJ	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PATJ	tfdimers__MD00038	TFAP2C (directAnnotation).
PATJ	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PATJ	metacluster_7.13	ZFX (directAnnotation).
PATJ	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PATJ	cisbp__M00968	MTF2 (directAnnotation).
PATJ	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PATJ	metacluster_160.20	JUND; PRDM15 (directAnnotation).
PATJ	cisbp__M00341	PAX6 (directAnnotation).
PATJ	metacluster_198.3	ZFP64 (directAnnotation).
PATJ	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PATJ	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PATJ	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PATJ	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PATJ	cisbp__M00788	ZFY (inferredBy_Orthology).
PATJ	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PATJ	metacluster_175.1	ZNF283 (directAnnotation).
PATJ	hdpi__ZNF304	ZNF304 (directAnnotation).
PATJ	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
PATJ	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PATJ	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PATJ	transfac_pro__M01199	TRIM28 (directAnnotation).
PATJ	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PATJ	metacluster_151.2	ZNF23 (directAnnotation).
PATJ	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PATJ	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PATJ	transfac_pro__M03806	ZBTB7C (directAnnotation).
PATJ	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."