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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PASK

Summary for PASK

Gene information	Gene symbol	PASK
	Ensembl ID	ENSG00000115687
	Entrez ID	23178
	Gene name	PAS domain containing serine/threonine kinase
	Synonyms	KIAA0135\|PASKIN\|STK37
	Gene type	protein_coding
	UniProtAcc	Q96RG2

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Dataset with differentially expressed gene: PASK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.259288	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.384333	1.22e-04
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.289262	0.00e+00

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Expression of PASK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PASK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PASK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PASK	hsa-miR-3915	95.9081	NM_001252122
PASK	hsa-miR-5589-3p	90.4638	NM_001252122
PASK	hsa-miR-4659a-3p	90.3153	NM_001252124
PASK	hsa-miR-4659b-3p	90.3153	NM_001252124
PASK	hsa-miR-1278	90.1668	NM_001252124
PASK	hsa-miR-515-5p	88.9547	NM_001252122
PASK	hsa-miR-519e-5p	88.9547	NM_001252122
PASK	hsa-miR-4752	88.9255	NM_001252124
PASK	hsa-miR-3190-5p	88.8971	NM_001252122
PASK	hsa-miR-182-5p	86.4424	NM_001252124
PASK	hsa-miR-1537-5p	85.0455	NM_001252124
PASK	hsa-miR-297	82.9126	NM_001252124
PASK	hsa-miR-7978	82.7224	NM_001252122
PASK	hsa-miR-942-5p	80.8438	NM_001252124
PASK	hsa-miR-4264	80.724	NM_001252124

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Motifs and transcription factors (TFs) regulating PASK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PASK	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PASK	taipale_tf_pairs__TEAD4_ALX4_RCATWCYNNNNTAATYRNATTA_CAP_repr	ALX4; TEAD4 (directAnnotation).
PASK	metacluster_6.1	HMBOX1 (directAnnotation).
PASK	taipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNNTGCGGG_CAP	FIGLA; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."