Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PARPBP

Summary for PARPBP

Gene information	Gene symbol	PARPBP
	Ensembl ID	ENSG00000185480
	Entrez ID	55010
	Gene name	PARP1 binding protein
	Synonyms	C12orf48\|FLJ20641\|PARI
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: PARPBP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.45047	3.97e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.278911	0.00e+00

Top

Expression of PARPBP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PARPBP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PARPBP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PARPBP	hsa-miR-1297	97.2711	NM_001319996
PARPBP	hsa-miR-26a-5p	97.0331	NM_001319996
PARPBP	hsa-miR-26b-5p	97.0331	NM_001319996
PARPBP	hsa-miR-4465	96.5788	NM_001319996
PARPBP	hsa-miR-4775	96.3708	NM_001319996
PARPBP	hsa-miR-4422	96.2715	NM_001319993
PARPBP	hsa-miR-7977	95.3649	NM_001319993
PARPBP	hsa-miR-136-5p	92.7713	NM_001319996
PARPBP	hsa-miR-4476	92.6471	NM_001319993
PARPBP	hsa-miR-6876-5p	92.6471	NM_001319993
PARPBP	hsa-miR-19a-3p	92.124	NM_001319996
PARPBP	hsa-miR-19b-3p	92.124	NM_001319996
PARPBP	hsa-miR-551b-5p	91.8154	NM_001319993
PARPBP	hsa-miR-4682	91.5939	NM_001319993
PARPBP	hsa-miR-544a	91.5709	NM_001319988
PARPBP	hsa-miR-513a-3p	91.346	NM_001319993
PARPBP	hsa-miR-513c-3p	91.346	NM_001319993
PARPBP	hsa-miR-7852-3p	91.1827	NM_001319996
PARPBP	hsa-miR-3606-3p	90.9089	NM_001319993
PARPBP	hsa-miR-335-3p	87.7676	NM_001319996
PARPBP	hsa-miR-4731-3p	86.8046	NM_001319993
PARPBP	hsa-miR-4801	86.8046	NM_001319993
PARPBP	hsa-miR-3923	86.52	NM_001319993
PARPBP	hsa-miR-6857-5p	85.7227	NM_001319993
PARPBP	hsa-miR-6780a-3p	85.1455	NM_001319993
PARPBP	hsa-miR-8084	84.7137	NM_001319996
PARPBP	hsa-miR-610	84.6365	NM_001319996
PARPBP	hsa-miR-299-5p	84.0617	NM_001319993
PARPBP	hsa-miR-4804-3p	83.3698	NM_001319993
PARPBP	hsa-miR-4766-5p	83.2678	NM_001319993
PARPBP	hsa-let-7f-1-3p	82.0742	NM_001319993
PARPBP	hsa-let-7a-3p	82.0742	NM_001319993
PARPBP	hsa-miR-98-3p	82.0742	NM_001319993
PARPBP	hsa-let-7b-3p	82.0742	NM_001319993
PARPBP	hsa-miR-6820-3p	80.4001	NM_001319993
PARPBP	hsa-miR-3164	80.4001	NM_001319993

Page: 1

Top

Motifs and transcription factors (TFs) regulating PARPBP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PARPBP	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PARPBP	hdpi__ETV4	ETV4 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."