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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PARM1

Summary for PARM1

Gene information	Gene symbol	PARM1
	Ensembl ID	ENSG00000169116
	Entrez ID	25849
	Gene name	prostate androgen-regulated mucin-like protein 1
	Synonyms	Cipar1\|DKFZP564O0823\|WSC4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PARM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.419122	0.00e+00

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Expression of PARM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PARM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PARM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PARM1	hsa-miR-6867-5p	95.5447	NM_015393
PARM1	hsa-miR-6873-3p	94.1398	NM_015393
PARM1	hsa-miR-3913-3p	93.6214	NM_015393
PARM1	hsa-miR-6826-3p	92.8473	NM_015393
PARM1	hsa-miR-10401-5p	89.6337	NM_015393
PARM1	hsa-miR-3133	89.5995	NM_015393
PARM1	hsa-miR-489-3p	88.5415	NM_015393
PARM1	hsa-miR-4262	88.2551	NM_015393
PARM1	hsa-miR-579-3p	88.1605	NM_015393
PARM1	hsa-miR-664b-3p	88.1605	NM_015393
PARM1	hsa-miR-3674	88.0789	NM_015393
PARM1	hsa-miR-320a-5p	87.6937	NM_015393
PARM1	hsa-miR-3529-3p	87.5567	NM_015393
PARM1	hsa-miR-181d-5p	86.474	NM_015393
PARM1	hsa-miR-181c-5p	86.474	NM_015393
PARM1	hsa-miR-181a-5p	86.474	NM_015393
PARM1	hsa-miR-181b-5p	86.474	NM_015393
PARM1	hsa-miR-9986	86.036	NM_015393
PARM1	hsa-miR-1294	86.036	NM_015393
PARM1	hsa-miR-5009-3p	84.9165	NM_015393
PARM1	hsa-miR-4500	83.1368	NM_015393
PARM1	hsa-miR-4677-3p	82.8159	NM_015393

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Motifs and transcription factors (TFs) regulating PARM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PARM1	transfac_pro__M04748	GABPA (directAnnotation).
PARM1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
PARM1	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
PARM1	metacluster_122.17	IRF6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."