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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PARD6B

Summary for PARD6B

Gene information	Gene symbol	PARD6B
	Ensembl ID	ENSG00000124171
	Entrez ID	84612
	Gene name	par-6 family cell polarity regulator beta
	Synonyms	PAR-6B
	Gene type	protein_coding
	UniProtAcc	Q9BYG5

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Dataset with differentially expressed gene: PARD6B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.837844	1.09e-02
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.272676	2.94e-07

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Expression of PARD6B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PARD6B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PARD6B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PARD6B	hsa-miR-4282	99.6153	NM_032521
PARD6B	hsa-miR-548c-3p	98.4477	NM_032521
PARD6B	hsa-let-7c-3p	95.9094	NM_032521
PARD6B	hsa-miR-381-3p	94.8279	NM_032521
PARD6B	hsa-miR-4524b-5p	94.2416	NM_032521
PARD6B	hsa-miR-4524a-5p	94.2416	NM_032521
PARD6B	hsa-miR-582-5p	94.0963	NM_032521
PARD6B	hsa-miR-382-3p	93.7462	NM_032521
PARD6B	hsa-miR-6882-5p	93.6286	NM_032521
PARD6B	hsa-miR-3613-3p	93.6169	NM_032521
PARD6B	hsa-miR-300	93.4347	NM_032521
PARD6B	hsa-miR-27a-3p	93.3656	NM_032521
PARD6B	hsa-miR-27b-3p	93.3656	NM_032521
PARD6B	hsa-miR-9985	93.3656	NM_032521
PARD6B	hsa-miR-3163	93.2188	NM_032521
PARD6B	hsa-miR-374a-5p	92.8274	NM_032521
PARD6B	hsa-miR-374b-5p	92.6699	NM_032521
PARD6B	hsa-miR-4257	92.6297	NM_032521
PARD6B	hsa-miR-551b-5p	92.1298	NM_032521
PARD6B	hsa-miR-6516-3p	91.9951	NM_032521
PARD6B	hsa-miR-888-3p	91.7935	NM_032521
PARD6B	hsa-miR-616-5p	91.1775	NM_032521
PARD6B	hsa-miR-373-5p	91.1775	NM_032521
PARD6B	hsa-miR-371b-5p	91.1775	NM_032521
PARD6B	hsa-miR-3679-3p	89.8689	NM_032521
PARD6B	hsa-miR-4460	89.5942	NM_032521
PARD6B	hsa-miR-520b-5p	89.5278	NM_032521
PARD6B	hsa-miR-519a-2-5p	89.5278	NM_032521
PARD6B	hsa-miR-769-5p	89.4071	NM_032521
PARD6B	hsa-miR-6779-3p	88.8413	NM_032521
PARD6B	hsa-miR-18a-5p	88.4275	NM_032521
PARD6B	hsa-miR-18b-5p	88.4275	NM_032521
PARD6B	hsa-let-7a-3p	88.4015	NM_032521
PARD6B	hsa-let-7f-1-3p	88.4015	NM_032521
PARD6B	hsa-miR-98-3p	88.4015	NM_032521
PARD6B	hsa-let-7b-3p	88.4015	NM_032521
PARD6B	hsa-miR-646	88.3154	NM_032521
PARD6B	hsa-miR-106b-5p	87.4135	NM_032521
PARD6B	hsa-miR-23a-3p	87.0603	NM_032521
PARD6B	hsa-miR-23b-3p	87.0603	NM_032521
PARD6B	hsa-miR-23c	87.0603	NM_032521
PARD6B	hsa-miR-5582-3p	86.7913	NM_032521
PARD6B	hsa-miR-548at-5p	86.6933	NM_032521
PARD6B	hsa-miR-5692a	86.4779	NM_032521
PARD6B	hsa-miR-17-5p	85.5975	NM_032521
PARD6B	hsa-miR-106a-5p	85.5975	NM_032521
PARD6B	hsa-miR-12136	85.5093	NM_032521
PARD6B	hsa-miR-4735-3p	84.5071	NM_032521
PARD6B	hsa-miR-202-3p	84.1044	NM_032521
PARD6B	hsa-miR-6780a-5p	83.7149	NM_032521

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Motifs and transcription factors (TFs) regulating PARD6B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PARD6B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PARD6B	taipale_tf_pairs__TEAD4_MAX_RGAATGYNNACGTG_CAP_repr	MAX; TEAD4 (directAnnotation).
PARD6B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PARD6B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PARD6B	transfac_pro__M04617	ZBTB7A (directAnnotation).
PARD6B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PARD6B	transfac_pro__M07436	WT1 (directAnnotation).
PARD6B	transfac_pro__M00716	ZBTB14 (directAnnotation).
PARD6B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PARD6B	hdpi__HIP2	UBE2K (directAnnotation).
PARD6B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PARD6B	transfac_pro__M04893	TAF1 (directAnnotation).
PARD6B	transfac_pro__M03876	ZBTB33 (directAnnotation).
PARD6B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PARD6B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PARD6B	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PARD6B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PARD6B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."