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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAPSS2

Summary for PAPSS2

Gene information	Gene symbol	PAPSS2
	Ensembl ID	ENSG00000198682
	Entrez ID	9060
	Gene name	3'-phosphoadenosine 5'-phosphosulfate synthase 2
	Synonyms	ATPSK2
	Gene type	protein_coding
	UniProtAcc	O95340

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Dataset with differentially expressed gene: PAPSS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.303656	1.03e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.7964	0.00e+00

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Expression of PAPSS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAPSS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAPSS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAPSS2	hsa-miR-6867-5p	99.3107	NM_004670
PAPSS2	hsa-miR-5011-5p	98.9503	NM_004670
PAPSS2	hsa-miR-3714	97.2534	NM_001015880
PAPSS2	hsa-miR-2278	95.0891	NM_001015880
PAPSS2	hsa-miR-4753-3p	94.9088	NM_004670
PAPSS2	hsa-miR-493-5p	93.0088	NM_004670
PAPSS2	hsa-let-7g-3p	92.7546	NM_004670
PAPSS2	hsa-let-7a-2-3p	92.7546	NM_004670
PAPSS2	hsa-miR-3658	92.6451	NM_004670
PAPSS2	hsa-miR-506-3p	91.9592	NM_001015880
PAPSS2	hsa-miR-124-3p	91.9592	NM_001015880
PAPSS2	hsa-miR-95-5p	90.7065	NM_001015880
PAPSS2	hsa-miR-297	90.2087	NM_004670
PAPSS2	hsa-miR-1236-3p	90.1677	NM_001015880
PAPSS2	hsa-miR-203a-3p	90.1677	NM_001015880
PAPSS2	hsa-miR-190a-3p	89.8989	NM_004670
PAPSS2	hsa-miR-1305	89.8253	NM_001015880
PAPSS2	hsa-miR-196a-3p	88.2859	NM_004670
PAPSS2	hsa-miR-6809-3p	88.0244	NM_004670
PAPSS2	hsa-miR-4711-5p	87.6959	NM_004670
PAPSS2	hsa-miR-3121-3p	87.0123	NM_004670
PAPSS2	hsa-miR-548an	86.8085	NM_004670
PAPSS2	hsa-miR-4528	86.762	NM_004670
PAPSS2	hsa-miR-542-3p	86.7495	NM_004670
PAPSS2	hsa-miR-758-3p	86.0002	NM_004670
PAPSS2	hsa-miR-92b-3p	85.9381	NM_004670
PAPSS2	hsa-miR-32-5p	85.9381	NM_004670
PAPSS2	hsa-miR-92a-3p	85.9381	NM_004670
PAPSS2	hsa-miR-3613-5p	85.6704	NM_004670
PAPSS2	hsa-miR-376c-3p	83.6756	NM_004670
PAPSS2	hsa-miR-25-3p	83.426	NM_004670
PAPSS2	hsa-miR-363-3p	83.426	NM_004670
PAPSS2	hsa-miR-367-3p	83.426	NM_004670
PAPSS2	hsa-miR-34b-5p	82.7896	NM_004670
PAPSS2	hsa-miR-2682-5p	82.7896	NM_004670
PAPSS2	hsa-miR-449c-5p	82.7896	NM_004670
PAPSS2	hsa-miR-4328	81.8767	NM_001015880

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Motifs and transcription factors (TFs) regulating PAPSS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAPSS2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PAPSS2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
PAPSS2	transfac_pro__M00652	NRF1 (directAnnotation).
PAPSS2	transfac_pro__M05612	ZNF189 (directAnnotation).
PAPSS2	transfac_pro__M05418	ZNF521 (directAnnotation).
PAPSS2	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
PAPSS2	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
PAPSS2	tfdimers__MD00208	IRF1; LTF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."