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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAN3

Summary for PAN3

Gene information	Gene symbol	PAN3
	Ensembl ID	ENSG00000152520
	Entrez ID	255967
	Gene name	poly(A) specific ribonuclease subunit PAN3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q58A45

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Dataset with differentially expressed gene: PAN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.268325	3.95e-08

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Expression of PAN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAN3	hsa-miR-4671-3p	99.1855	NM_175854
PAN3	hsa-miR-570-3p	99.0468	NM_175854
PAN3	hsa-miR-4666a-3p	98.4482	NM_175854
PAN3	hsa-miR-4659b-3p	98.2452	NM_175854
PAN3	hsa-miR-4659a-3p	98.2452	NM_175854
PAN3	hsa-miR-3688-5p	98.1898	NM_175854
PAN3	hsa-miR-548aj-3p	98.1871	NM_175854
PAN3	hsa-miR-548x-3p	98.1871	NM_175854
PAN3	hsa-miR-548ah-3p	97.9292	NM_175854
PAN3	hsa-miR-548j-3p	97.9292	NM_175854
PAN3	hsa-miR-548ae-3p	97.9292	NM_175854
PAN3	hsa-miR-548am-3p	97.9292	NM_175854
PAN3	hsa-miR-548aq-3p	97.9292	NM_175854
PAN3	hsa-miR-4477a	97.535	NM_175854
PAN3	hsa-miR-6772-3p	96.8409	NM_175854
PAN3	hsa-miR-4448	96.8157	NM_175854
PAN3	hsa-miR-454-3p	96.7904	NM_175854
PAN3	hsa-miR-1250-3p	96.763	NM_175854
PAN3	hsa-miR-381-3p	96.6443	NM_175854
PAN3	hsa-miR-300	96.6443	NM_175854
PAN3	hsa-miR-301b-3p	96.1414	NM_175854
PAN3	hsa-miR-301a-3p	96.1414	NM_175854
PAN3	hsa-miR-4295	95.8979	NM_175854
PAN3	hsa-miR-130b-3p	95.8979	NM_175854
PAN3	hsa-miR-3666	95.8979	NM_175854
PAN3	hsa-miR-130a-3p	95.8979	NM_175854
PAN3	hsa-miR-320b	95.6829	NM_175854
PAN3	hsa-miR-4429	95.6829	NM_175854
PAN3	hsa-miR-320c	95.6829	NM_175854
PAN3	hsa-miR-320d	95.6829	NM_175854
PAN3	hsa-miR-320a-3p	95.6829	NM_175854
PAN3	hsa-miR-501-5p	95.6757	NM_175854
PAN3	hsa-miR-590-5p	95.239	NM_175854
PAN3	hsa-miR-4699-3p	94.7172	NM_175854
PAN3	hsa-miR-5584-3p	94.5039	NM_175854
PAN3	hsa-miR-10527-5p	94.3434	NM_175854
PAN3	hsa-miR-3613-3p	94.2826	NM_175854
PAN3	hsa-miR-6875-3p	93.9372	NM_175854
PAN3	hsa-miR-3148	93.7435	NM_175854
PAN3	hsa-miR-6841-3p	93.2686	NM_175854
PAN3	hsa-miR-21-5p	93.2601	NM_175854
PAN3	hsa-miR-4719	93.2	NM_175854
PAN3	hsa-miR-7161-5p	93.0436	NM_175854
PAN3	hsa-miR-548u	93.0436	NM_175854
PAN3	hsa-miR-1297	92.4622	NM_175854
PAN3	hsa-miR-8087	92.3968	NM_175854
PAN3	hsa-miR-9-3p	92.2177	NM_175854
PAN3	hsa-miR-338-5p	91.9662	NM_175854
PAN3	hsa-miR-4770	91.9456	NM_175854
PAN3	hsa-miR-143-3p	91.9456	NM_175854

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Motifs and transcription factors (TFs) regulating PAN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAN3	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
PAN3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PAN3	jaspar__MA1122.1	TFDP1 (directAnnotation).
PAN3	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
PAN3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PAN3	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
PAN3	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."