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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAIP2B

Summary for PAIP2B

Gene information	Gene symbol	PAIP2B
	Ensembl ID	ENSG00000124374
	Entrez ID	400961
	Gene name	poly(A) binding protein interacting protein 2B
	Synonyms	KIAA1155
	Gene type	protein_coding
	UniProtAcc	Q9ULR5

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Dataset with differentially expressed gene: PAIP2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.25325	0.00e+00

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Expression of PAIP2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAIP2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAIP2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAIP2B	hsa-miR-587	93.8706	NM_020459
PAIP2B	hsa-miR-548aw	92.0074	NM_020459
PAIP2B	hsa-miR-5087	91.1624	NM_020459
PAIP2B	hsa-miR-4446-5p	88.2613	NM_020459
PAIP2B	hsa-miR-7154-5p	87.5526	NM_020459
PAIP2B	hsa-miR-22-3p	86.693	NM_020459
PAIP2B	hsa-miR-302c-5p	86.3747	NM_020459
PAIP2B	hsa-miR-27b-3p	85.9104	NM_020459
PAIP2B	hsa-miR-27a-3p	85.9104	NM_020459
PAIP2B	hsa-miR-9985	85.9104	NM_020459
PAIP2B	hsa-miR-1-5p	85.6493	NM_020459
PAIP2B	hsa-miR-4684-3p	85.0321	NM_020459
PAIP2B	hsa-miR-922	85.0271	NM_020459
PAIP2B	hsa-miR-3148	84.917	NM_020459
PAIP2B	hsa-miR-3145-3p	84.7123	NM_020459
PAIP2B	hsa-miR-299-3p	84.4977	NM_020459
PAIP2B	hsa-miR-5000-3p	84.0152	NM_020459
PAIP2B	hsa-miR-4728-5p	83.0209	NM_020459
PAIP2B	hsa-miR-6785-5p	83.0209	NM_020459
PAIP2B	hsa-miR-149-3p	82.6439	NM_020459
PAIP2B	hsa-miR-6883-5p	82.6439	NM_020459
PAIP2B	hsa-miR-373-5p	81.8464	NM_020459
PAIP2B	hsa-miR-616-5p	81.8464	NM_020459
PAIP2B	hsa-miR-371b-5p	81.8464	NM_020459
PAIP2B	hsa-miR-4436a	81.3038	NM_020459
PAIP2B	hsa-miR-329-3p	80.3148	NM_020459
PAIP2B	hsa-miR-362-3p	80.3148	NM_020459
PAIP2B	hsa-miR-3188	80.2922	NM_020459
PAIP2B	hsa-miR-6783-5p	80.2703	NM_020459

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Motifs and transcription factors (TFs) regulating PAIP2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAIP2B	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
PAIP2B	transfac_pro__M06196	ZNF81 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."