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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PAF1

Summary for PAF1

Gene information	Gene symbol	PAF1
	Ensembl ID	ENSG00000006712
	Entrez ID	54623
	Gene name	PAF1 homolog, Paf1/RNA polymerase II complex component
	Synonyms	F23149_1\|FLJ11123\|PD2
	Gene type	protein_coding
	UniProtAcc	Q8N7H5

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Dataset with differentially expressed gene: PAF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.80535	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.27831	0.00e+00

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Expression of PAF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAF1	hsa-miR-495-3p	97.5587	NM_001256826
PAF1	hsa-miR-5688	97.5587	NM_001256826
PAF1	hsa-miR-3148	89.9422	NM_001256826
PAF1	hsa-miR-302e	86.8127	NM_019088
PAF1	hsa-miR-222-3p	84.788	NM_001256826
PAF1	hsa-miR-221-3p	84.788	NM_001256826
PAF1	hsa-miR-6780b-5p	84.6275	NM_001256826
PAF1	hsa-miR-4725-3p	84.6275	NM_001256826
PAF1	hsa-miR-3120-3p	83.9785	NM_001256826
PAF1	hsa-miR-520b-3p	83.6688	NM_019088
PAF1	hsa-miR-302d-3p	83.6688	NM_019088
PAF1	hsa-miR-520d-3p	83.6688	NM_019088
PAF1	hsa-miR-302b-3p	83.6688	NM_019088
PAF1	hsa-miR-373-3p	83.6688	NM_019088
PAF1	hsa-miR-302c-3p	83.6688	NM_019088
PAF1	hsa-miR-302a-3p	83.6688	NM_019088
PAF1	hsa-miR-520c-3p	83.6688	NM_019088
PAF1	hsa-miR-372-3p	83.6688	NM_019088
PAF1	hsa-miR-520e-3p	83.6688	NM_019088
PAF1	hsa-miR-520a-3p	83.6688	NM_019088
PAF1	hsa-miR-4271	83.154	NM_001256826
PAF1	hsa-miR-27a-5p	81.9677	NM_001256826
PAF1	hsa-miR-378g	80.12	NM_001256826

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Motifs and transcription factors (TFs) regulating PAF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAF1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PAF1	transfac_pro__M04862	NRF1 (directAnnotation).
PAF1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."