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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PACSIN1

Summary for PACSIN1

Gene information	Gene symbol	PACSIN1
	Ensembl ID	ENSG00000124507
	Entrez ID	29993
	Gene name	protein kinase C and casein kinase substrate in neurons 1
	Synonyms	SDPI
	Gene type	protein_coding
	UniProtAcc	Q9BY11

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Dataset with differentially expressed gene: PACSIN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.697667	2.41e-04

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Expression of PACSIN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PACSIN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PACSIN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PACSIN1	hsa-miR-5011-5p	99.9673	NM_020804
PACSIN1	hsa-miR-190a-3p	99.9051	NM_020804
PACSIN1	hsa-miR-7106-5p	96.3512	NM_020804
PACSIN1	hsa-miR-6825-5p	96.1843	NM_020804
PACSIN1	hsa-miR-4728-5p	94.8537	NM_020804
PACSIN1	hsa-miR-149-3p	94.0506	NM_020804
PACSIN1	hsa-miR-6785-5p	93.98	NM_020804
PACSIN1	hsa-miR-6880-5p	92.2461	NM_020804
PACSIN1	hsa-miR-6883-5p	91.0031	NM_020804
PACSIN1	hsa-miR-100-3p	89.6219	NM_020804
PACSIN1	hsa-miR-3202	88.4437	NM_020804
PACSIN1	hsa-miR-6721-5p	85.747	NM_001199583
PACSIN1	hsa-miR-125b-2-3p	84.9256	NM_001199583
PACSIN1	hsa-miR-2052	84.6029	NM_020804
PACSIN1	hsa-miR-4481	84.1378	NM_001199583
PACSIN1	hsa-miR-4680-5p	83.945	NM_001199583
PACSIN1	hsa-miR-654-3p	81.3977	NM_020804

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Motifs and transcription factors (TFs) regulating PACSIN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PACSIN1	tfdimers__MD00274	MYCN (directAnnotation).
PACSIN1	transfac_pro__M03847	SOX15 (directAnnotation).
PACSIN1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
PACSIN1	tfdimers__MD00068	HSF2; MYCN (directAnnotation).
PACSIN1	transfac_pro__M05664	ZNF853 (directAnnotation).
PACSIN1	tfdimers__MD00273	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; MZF1 (directAnnotation).
PACSIN1	taipale_tf_pairs__ARNTL_BHLHA15_RKCACGTGNNNMCATATGKN_CAP_repr	ARNTL; BHLHA15 (directAnnotation).
PACSIN1	transfac_pro__M05933	ZNF552 (directAnnotation).
PACSIN1	transfac_pro__M06470	ZNF441 (directAnnotation).
PACSIN1	metacluster_130.18	FOXD2; FOXD2 (directAnnotation). FOXA2; FOXD2; FOXD2 (inferredBy_Orthology).
PACSIN1	swissregulon__hs__ZKSCAN3	ZKSCAN3 (directAnnotation).
PACSIN1	tfdimers__MD00517	POU5F1 (directAnnotation).
PACSIN1	tfdimers__MD00502	PBX1; SOX9 (directAnnotation).
PACSIN1	kznf__ZNF136_Imbeault2017_RP_RCADE	ZNF136 (directAnnotation).
PACSIN1	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
PACSIN1	taipale_cyt_meth__TLX3_NAATTGNNNNNNNNNNCAATTN_FL_repr	TLX3 (directAnnotation).
PACSIN1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
PACSIN1	tfdimers__MD00330	FOXP3; HSF1 (directAnnotation).
PACSIN1	tfdimers__MD00599	NR1I2; RXRA; STAT1 (directAnnotation).
PACSIN1	tfdimers__MD00478	SOX10; ZNF217 (directAnnotation).
PACSIN1	tfdimers__MD00064	E2F1; LTF (directAnnotation).
PACSIN1	transfac_pro__M05462	ZNF581 (directAnnotation).
PACSIN1	tfdimers__MD00602	MYB; STAT6 (directAnnotation).
PACSIN1	hocomoco__HMBX1_HUMAN.H11MO.0.D	HMBOX1 (directAnnotation).
PACSIN1	tfdimers__MD00090	FOS; FOXG1; FOXO1 (directAnnotation).
PACSIN1	transfac_pro__M04906	SIN3A (directAnnotation).
PACSIN1	taipale_tf_pairs__TEAD4_PITX1_RCATWCYNNNNTAATCC_CAP_repr	PITX1; TEAD4 (directAnnotation).
PACSIN1	transfac_pro__M06116	ZNF28 (directAnnotation).
PACSIN1	transfac_pro__M06425	ZNF227 (directAnnotation).
PACSIN1	tfdimers__MD00494	SOX9; TBP (directAnnotation).
PACSIN1	transfac_pro__M04861	SIX5 (directAnnotation).
PACSIN1	transfac_pro__M06122	ZNF43 (directAnnotation).
PACSIN1	transfac_pro__M05668	ZNF154 (directAnnotation).
PACSIN1	metacluster_70.17	POU1F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."