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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PACS1

Summary for PACS1

Gene information	Gene symbol	PACS1
	Ensembl ID	ENSG00000175115
	Entrez ID	55690
	Gene name	phosphofurin acidic cluster sorting protein 1
	Synonyms	FLJ10209\|KIAA1175
	Gene type	protein_coding
	UniProtAcc	Q6VY07

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Dataset with differentially expressed gene: PACS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.42854	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.268341	3.07e-18
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.300137	0.00e+00

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Expression of PACS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PACS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PACS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PACS1	hsa-miR-4492	99.6267	NM_018026
PACS1	hsa-miR-6797-5p	99.3094	NM_018026
PACS1	hsa-miR-4505	99.1151	NM_018026
PACS1	hsa-miR-4498	99.0202	NM_018026
PACS1	hsa-miR-5787	98.932	NM_018026
PACS1	hsa-miR-1249-5p	98.8593	NM_018026
PACS1	hsa-miR-762	98.7893	NM_018026
PACS1	hsa-miR-5001-5p	98.659	NM_018026
PACS1	hsa-miR-5196-5p	98.6376	NM_018026
PACS1	hsa-miR-4747-5p	98.1255	NM_018026
PACS1	hsa-miR-449a	97.6564	NM_018026
PACS1	hsa-miR-34a-5p	97.6564	NM_018026
PACS1	hsa-miR-4728-5p	97.6234	NM_018026
PACS1	hsa-miR-6785-5p	97.5495	NM_018026
PACS1	hsa-miR-4779	96.6032	NM_018026
PACS1	hsa-miR-6127	95.8289	NM_018026
PACS1	hsa-miR-449b-5p	95.7665	NM_018026
PACS1	hsa-miR-34c-5p	95.7665	NM_018026
PACS1	hsa-miR-149-3p	95.6844	NM_018026
PACS1	hsa-miR-6883-5p	95.6844	NM_018026
PACS1	hsa-miR-6133	94.0477	NM_018026
PACS1	hsa-miR-6130	94.0477	NM_018026
PACS1	hsa-miR-6129	94.0477	NM_018026
PACS1	hsa-miR-4510	94.0477	NM_018026
PACS1	hsa-miR-6799-5p	91.6064	NM_018026
PACS1	hsa-miR-3184-5p	91.498	NM_018026
PACS1	hsa-miR-4731-5p	89.7518	NM_018026
PACS1	hsa-miR-1910-3p	89.5035	NM_018026
PACS1	hsa-miR-5006-5p	89.1882	NM_018026
PACS1	hsa-miR-597-5p	89.0268	NM_018026
PACS1	hsa-miR-6511a-5p	88.2001	NM_018026
PACS1	hsa-miR-5698	88.0229	NM_018026
PACS1	hsa-miR-4723-5p	88.0229	NM_018026
PACS1	hsa-miR-7111-5p	88.0229	NM_018026
PACS1	hsa-miR-6870-5p	88.0229	NM_018026
PACS1	hsa-miR-3135b	87.3743	NM_018026
PACS1	hsa-miR-1827	86.3163	NM_018026
PACS1	hsa-miR-7106-5p	86.0921	NM_018026
PACS1	hsa-miR-4710	85.7133	NM_018026
PACS1	hsa-miR-6780a-5p	85.1441	NM_018026
PACS1	hsa-miR-423-5p	84.763	NM_018026
PACS1	hsa-miR-6779-5p	84.3437	NM_018026
PACS1	hsa-miR-30b-3p	84.3437	NM_018026
PACS1	hsa-miR-1273h-5p	84.3437	NM_018026
PACS1	hsa-miR-3689c	84.3437	NM_018026
PACS1	hsa-miR-3689a-3p	84.3437	NM_018026
PACS1	hsa-miR-3689b-3p	84.3437	NM_018026
PACS1	hsa-miR-6889-3p	83.7138	NM_018026
PACS1	hsa-miR-6737-3p	82.2958	NM_018026
PACS1	hsa-miR-7157-3p	82.2958	NM_018026

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Motifs and transcription factors (TFs) regulating PACS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PACS1	metacluster_7.13	ZFX (directAnnotation).
PACS1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PACS1	metacluster_151.2	ZNF23 (directAnnotation).
PACS1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PACS1	transfac_pro__M05479	ZNF580 (directAnnotation).
PACS1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PACS1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PACS1	transfac_pro__M06071	ZNF814 (directAnnotation).
PACS1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PACS1	jaspar__MA0079.5	SP1 (directAnnotation).
PACS1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PACS1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PACS1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PACS1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PACS1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
PACS1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
PACS1	transfac_pro__M01253	CNOT3 (directAnnotation).
PACS1	transfac_pro__M04817	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."