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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PABPC5

Summary for PABPC5

Gene information	Gene symbol	PABPC5
	Ensembl ID	ENSG00000174740
	Entrez ID	140886
	Gene name	poly(A) binding protein cytoplasmic 5
	Synonyms	PABP5
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PABPC5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-2.2606	2.63e-06

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Expression of PABPC5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PABPC5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PABPC5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PABPC5	hsa-miR-3662	99.8567	NM_080832
PABPC5	hsa-miR-5701	98.9741	NM_080832
PABPC5	hsa-miR-3613-3p	98.9508	NM_080832
PABPC5	hsa-miR-3646	98.7193	NM_080832
PABPC5	hsa-miR-4698	95.6677	NM_080832
PABPC5	hsa-miR-590-3p	95.6204	NM_080832
PABPC5	hsa-miR-3680-3p	95.5679	NM_080832
PABPC5	hsa-miR-3145-3p	94.7866	NM_080832
PABPC5	hsa-miR-26a-2-3p	93.0608	NM_080832
PABPC5	hsa-miR-26a-1-3p	93.0608	NM_080832
PABPC5	hsa-miR-12132	92.0116	NM_080832
PABPC5	hsa-miR-7-1-3p	91.8099	NM_080832
PABPC5	hsa-miR-7-2-3p	91.8099	NM_080832
PABPC5	hsa-miR-15b-3p	91.2105	NM_080832
PABPC5	hsa-miR-548ag	91.051	NM_080832
PABPC5	hsa-miR-548ai	91.051	NM_080832
PABPC5	hsa-miR-570-5p	91.051	NM_080832
PABPC5	hsa-miR-548ba	91.051	NM_080832
PABPC5	hsa-miR-373-5p	90.7999	NM_080832
PABPC5	hsa-miR-616-5p	90.7999	NM_080832
PABPC5	hsa-miR-371b-5p	90.7999	NM_080832
PABPC5	hsa-miR-4517	90.3331	NM_080832
PABPC5	hsa-miR-4521	89.7514	NM_080832
PABPC5	hsa-miR-8056	89.1368	NM_080832
PABPC5	hsa-miR-7112-3p	88.809	NM_080832
PABPC5	hsa-miR-582-5p	88.357	NM_080832
PABPC5	hsa-miR-548ar-3p	87.7331	NM_080832
PABPC5	hsa-miR-4775	87.6395	NM_080832
PABPC5	hsa-miR-7154-5p	86.5688	NM_080832
PABPC5	hsa-miR-944	86.4476	NM_080832
PABPC5	hsa-miR-5688	86.359	NM_080832
PABPC5	hsa-miR-548az-3p	84.9795	NM_080832
PABPC5	hsa-miR-548bc	84.9795	NM_080832
PABPC5	hsa-miR-548e-3p	84.9795	NM_080832
PABPC5	hsa-miR-548f-3p	84.9795	NM_080832
PABPC5	hsa-miR-548a-3p	84.9795	NM_080832
PABPC5	hsa-miR-3121-3p	84.7757	NM_080832
PABPC5	hsa-miR-495-3p	83.9664	NM_080832
PABPC5	hsa-miR-4438	83.1556	NM_080832
PABPC5	hsa-miR-153-5p	82.3873	NM_080832
PABPC5	hsa-miR-9983-3p	81.8097	NM_080832
PABPC5	hsa-miR-7114-5p	81.7621	NM_080832
PABPC5	hsa-miR-3148	80.8101	NM_080832
PABPC5	hsa-miR-450b-5p	80.247	NM_080832

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Motifs and transcription factors (TFs) regulating PABPC5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."