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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: P4HA1

Summary for P4HA1

Gene information	Gene symbol	P4HA1
	Ensembl ID	ENSG00000122884
	Entrez ID	5033
	Gene name	prolyl 4-hydroxylase subunit alpha 1
	Synonyms	C-P4Halpha(I)\|P4HA
	Gene type	protein_coding
	UniProtAcc	P13674

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Dataset with differentially expressed gene: P4HA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.315454	4.92e-21
GSE150930	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Mucosa-assisted lymphoid tissue (MALT) lymphoma	Immunotherapy	rituximab + cyclophosphamide + fludarabine	NA	Malignant cells	-0.280705	3.81e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.782391	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.270844	7.68e-40
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.357172	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.307449	3.42e-18

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Expression of P4HA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to P4HA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating P4HA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
P4HA1	hsa-miR-5694	97.0577	NM_000917
P4HA1	hsa-miR-506-3p	96.8133	NM_000917
P4HA1	hsa-miR-124-3p	96.8133	NM_000917
P4HA1	hsa-miR-491-3p	96.246	NM_001142595
P4HA1	hsa-miR-3912-5p	95.7248	NM_000917
P4HA1	hsa-miR-5582-5p	94.5463	NM_000917
P4HA1	hsa-miR-6165	94.3669	NM_001142595
P4HA1	hsa-miR-122-5p	92.8103	NM_000917
P4HA1	hsa-miR-9902	92.0753	NM_001142595
P4HA1	hsa-miR-3910	90.6641	NM_000917
P4HA1	hsa-miR-197-3p	89.4999	NM_001142595
P4HA1	hsa-miR-3714	87.7772	NM_000917
P4HA1	hsa-miR-6500-5p	87.6441	NM_001142595
P4HA1	hsa-miR-4633-3p	87.6441	NM_001142595
P4HA1	hsa-miR-215-3p	87.6114	NM_001142595
P4HA1	hsa-miR-3659	85.9209	NM_000917
P4HA1	hsa-miR-4263	84.9527	NM_001142595
P4HA1	hsa-miR-7106-5p	84.4241	NM_001142595
P4HA1	hsa-miR-1245b-3p	84.3941	NM_000917
P4HA1	hsa-miR-490-5p	84.0094	NM_000917
P4HA1	hsa-miR-3152-3p	83.3509	NM_000917
P4HA1	hsa-miR-4439	83.2316	NM_001142595
P4HA1	hsa-miR-3136-5p	83.2316	NM_001142595
P4HA1	hsa-miR-504-3p	81.7075	NM_000917
P4HA1	hsa-miR-30e-5p	81.3635	NM_000917
P4HA1	hsa-miR-30c-5p	81.3635	NM_000917
P4HA1	hsa-miR-30d-5p	81.3635	NM_000917
P4HA1	hsa-miR-30a-5p	81.3635	NM_000917
P4HA1	hsa-miR-30b-5p	81.3635	NM_000917
P4HA1	hsa-miR-3529-3p	80.4729	NM_001142595
P4HA1	hsa-miR-6072	80.0672	NM_000917

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Motifs and transcription factors (TFs) regulating P4HA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
P4HA1	metacluster_7.13	ZFX (directAnnotation).
P4HA1	metacluster_151.2	ZNF23 (directAnnotation).
P4HA1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
P4HA1	transfac_pro__M05479	ZNF580 (directAnnotation).
P4HA1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
P4HA1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
P4HA1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
P4HA1	jaspar__MA0748.2	YY2 (directAnnotation).
P4HA1	transfac_pro__M05628	ZNF735 (directAnnotation).
P4HA1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
P4HA1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
P4HA1	jaspar__MA1933.1	SREBF2 (directAnnotation).
P4HA1	jaspar__MA0079.5	SP1 (directAnnotation).
P4HA1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
P4HA1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
P4HA1	cisbp__M00968	MTF2 (directAnnotation).
P4HA1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
P4HA1	cisbp__M00341	PAX6 (directAnnotation).
P4HA1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
P4HA1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
P4HA1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
P4HA1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
P4HA1	cisbp__M00788	ZFY (inferredBy_Orthology).
P4HA1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
P4HA1	hdpi__ZNF304	ZNF304 (directAnnotation).
P4HA1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
P4HA1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
P4HA1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
P4HA1	transfac_pro__M01199	TRIM28 (directAnnotation).
P4HA1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
P4HA1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
P4HA1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
P4HA1	transfac_pro__M03806	ZBTB7C (directAnnotation).
P4HA1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
P4HA1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
P4HA1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
P4HA1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
P4HA1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
P4HA1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
P4HA1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
P4HA1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
P4HA1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
P4HA1	transfac_pro__M04950	EGR1 (directAnnotation).
P4HA1	jaspar__MA1117.1	RELB (directAnnotation).
P4HA1	taipale__MYBL2_DBD_AACCGTTAACGGNN	MYBL2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
P4HA1	"Ascorbic acid"	DB00126	small molecule
P4HA1	"Hydralazine"	DB01275	small molecule
P4HA1	"Proline"	DB00172	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."