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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: P2RY14

Summary for P2RY14

Gene information	Gene symbol	P2RY14
	Ensembl ID	ENSG00000174944
	Entrez ID	9934
	Gene name	purinergic receptor P2Y14
	Synonyms	GPR105\|KIAA0001
	Gene type	protein_coding
	UniProtAcc	Q15391

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Dataset with differentially expressed gene: P2RY14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.798897	3.23e-02

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Expression of P2RY14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to P2RY14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating P2RY14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
P2RY14	hsa-miR-1287-3p	94.0992	NM_014879
P2RY14	hsa-miR-3123	93.6424	NM_014879
P2RY14	hsa-miR-7703	92.122	NM_014879
P2RY14	hsa-miR-4652-3p	91.4028	NM_014879
P2RY14	hsa-miR-570-3p	89.8285	NM_014879
P2RY14	hsa-miR-297	89.3951	NM_014879
P2RY14	hsa-miR-4699-3p	89.3556	NM_014879
P2RY14	hsa-miR-1303	88.8858	NM_014879
P2RY14	hsa-miR-3976	88.3124	NM_014879
P2RY14	hsa-miR-3133	88.1734	NM_001081455
P2RY14	hsa-miR-3180-5p	88.0042	NM_014879
P2RY14	hsa-miR-4774-5p	86.9164	NM_014879
P2RY14	hsa-miR-9902	86.5264	NM_014879
P2RY14	hsa-miR-6740-3p	86.4805	NM_014879
P2RY14	hsa-miR-4775	85.8919	NM_014879
P2RY14	hsa-miR-2115-3p	84.4252	NM_014879
P2RY14	hsa-miR-2052	82.3191	NM_014879
P2RY14	hsa-miR-16-1-3p	82.1432	NM_014879
P2RY14	hsa-miR-376a-2-5p	82.1057	NM_001081455

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Motifs and transcription factors (TFs) regulating P2RY14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
P2RY14	metacluster_187.3	SPDEF; SPDEF (directAnnotation).
P2RY14	transfac_pro__M03847	SOX15 (directAnnotation).
P2RY14	tfdimers__MD00115	E2F1; NR1I2; RXRA (directAnnotation).
P2RY14	taipale_tf_pairs__ARNTL_BHLHA15_RKCACGTGNNNMCATATGKN_CAP_repr	ARNTL; BHLHA15 (directAnnotation).
P2RY14	transfac_pro__M06470	ZNF441 (directAnnotation).
P2RY14	taipale_tf_pairs__GCM2_TBX21_NNNCGGGNNNGGTGTNN_CAP_repr	GCM2; TBX21 (directAnnotation).
P2RY14	transfac_pro__M05722	ZNF8 (directAnnotation).
P2RY14	swissregulon__hs__ZKSCAN3	ZKSCAN3 (directAnnotation).
P2RY14	transfac_pro__M06015	ZNF729 (directAnnotation).
P2RY14	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
P2RY14	transfac_pro__M06364	ZNF841 (directAnnotation).
P2RY14	taipale_cyt_meth__TLX3_NAATTGNNNNNNNNNNCAATTN_FL_repr	TLX3 (directAnnotation).
P2RY14	transfac_pro__M06049	ZNF208 (directAnnotation).
P2RY14	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
P2RY14	transfac_pro__M06419	ZNF493 (directAnnotation).
P2RY14	tfdimers__MD00040	IKZF2; POU2F1 (directAnnotation).
P2RY14	transfac_pro__M06806	PEG3 (directAnnotation).
P2RY14	metacluster_65.3	ZNF45 (directAnnotation).
P2RY14	tfdimers__MD00570	NEUROD1; NR3C1 (directAnnotation).
P2RY14	metacluster_19.11	MTF1 (directAnnotation).
P2RY14	transfac_pro__M04906	SIN3A (directAnnotation).
P2RY14	tfdimers__MD00268	PITX3; PPARG (directAnnotation).
P2RY14	tfdimers__MD00101	HOXA13; IKZF1 (directAnnotation).
P2RY14	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP_repr	ELK1; POU2F1 (directAnnotation).
P2RY14	transfac_pro__M04861	SIX5 (directAnnotation).
P2RY14	hdpi__OLIG3	OLIG3 (directAnnotation).
P2RY14	transfac_pro__M05424	ZNF296 (directAnnotation).
P2RY14	transfac_pro__M06122	ZNF43 (directAnnotation).
P2RY14	metacluster_70.17	POU1F1 (directAnnotation).
P2RY14	transfac_pro__M06416	ZNF429 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."