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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: P2RY10

Summary for P2RY10

Gene information	Gene symbol	P2RY10
	Ensembl ID	ENSG00000078589
	Entrez ID	27334
	Gene name	P2Y receptor family member 10
	Synonyms	P2Y10
	Gene type	protein_coding
	UniProtAcc	O00398

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Dataset with differentially expressed gene: P2RY10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.569239	0.00e+00

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Expression of P2RY10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to P2RY10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating P2RY10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
P2RY10	hsa-miR-4436b-5p	92.5452	NM_198333
P2RY10	hsa-miR-509-3-5p	90.6289	NM_198333
P2RY10	hsa-miR-509-5p	90.6289	NM_198333
P2RY10	hsa-miR-3922-3p	89.7215	NM_198333
P2RY10	hsa-miR-3613-3p	88.6094	NM_198333
P2RY10	hsa-miR-6875-3p	88.5528	NM_198333
P2RY10	hsa-miR-4418	88.444	NM_198333
P2RY10	hsa-miR-3176	87.7394	NM_198333
P2RY10	hsa-miR-4311	87.6704	NM_198333
P2RY10	hsa-miR-4533	85.0931	NM_198333
P2RY10	hsa-miR-4452	83.5846	NM_001324218
P2RY10	hsa-miR-522-3p	82.986	NM_198333
P2RY10	hsa-miR-224-3p	82.986	NM_198333
P2RY10	hsa-miR-4279	82.7161	NM_198333
P2RY10	hsa-miR-488-3p	82.3638	NM_198333
P2RY10	hsa-miR-183-3p	82.2689	NM_001324218
P2RY10	hsa-miR-376a-5p	82.1348	NM_198333
P2RY10	hsa-miR-6833-3p	81.9009	NM_198333
P2RY10	hsa-miR-6876-5p	81.6197	NM_198333
P2RY10	hsa-miR-4476	81.6197	NM_198333
P2RY10	hsa-miR-6830-5p	81.4847	NM_198333
P2RY10	hsa-miR-3911	80.9775	NM_198333
P2RY10	hsa-miR-548k	80.8402	NM_198333
P2RY10	hsa-miR-548av-5p	80.8402	NM_198333
P2RY10	hsa-miR-5707	80.508	NM_198333
P2RY10	hsa-miR-8054	80.4883	NM_198333
P2RY10	hsa-miR-3133	80.1827	NM_198333

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Motifs and transcription factors (TFs) regulating P2RY10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
P2RY10	transfac_pro__M01861	ATF1 (directAnnotation).
P2RY10	transfac_pro__M05402	BCL6B (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."