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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OTULIN

Summary for OTULIN

Gene information	Gene symbol	OTULIN
	Ensembl ID	ENSG00000154124
	Entrez ID	90268
	Gene name	OTU deubiquitinase with linear linkage specificity
	Synonyms	FAM105B\|FLJ34884
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: OTULIN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.342976	1.75e-14
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.274422	1.41e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.614229	2.82e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.363206	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.518865	0.00e+00

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Expression of OTULIN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OTULIN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OTULIN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OTULIN	hsa-miR-6780a-3p	97.3828	NM_138348
OTULIN	hsa-miR-128-3p	97.1227	NM_138348
OTULIN	hsa-miR-216a-3p	95.9381	NM_138348
OTULIN	hsa-miR-377-3p	95.6789	NM_138348
OTULIN	hsa-miR-8485	94.9329	NM_138348
OTULIN	hsa-miR-3681-3p	93.94	NM_138348
OTULIN	hsa-miR-3613-3p	92.7757	NM_138348
OTULIN	hsa-miR-4516	92.531	NM_138348
OTULIN	hsa-miR-5682	91.8955	NM_138348
OTULIN	hsa-miR-12132	91.0687	NM_138348
OTULIN	hsa-miR-9985	89.7708	NM_138348
OTULIN	hsa-miR-27b-3p	89.7708	NM_138348
OTULIN	hsa-miR-27a-3p	89.7708	NM_138348
OTULIN	hsa-miR-3163	88.4957	NM_138348
OTULIN	hsa-miR-4434	88.0932	NM_138348
OTULIN	hsa-miR-5703	88.0932	NM_138348
OTULIN	hsa-miR-4524a-3p	87.1681	NM_138348
OTULIN	hsa-miR-6783-5p	86.9836	NM_138348
OTULIN	hsa-miR-3133	86.8641	NM_138348
OTULIN	hsa-miR-4720-3p	86.7126	NM_138348
OTULIN	hsa-miR-500a-3p	86.5491	NM_138348
OTULIN	hsa-miR-7111-3p	84.8331	NM_138348
OTULIN	hsa-miR-29a-3p	84.5506	NM_138348
OTULIN	hsa-miR-29b-3p	84.5506	NM_138348
OTULIN	hsa-miR-29c-3p	84.5506	NM_138348
OTULIN	hsa-miR-944	84.3673	NM_138348
OTULIN	hsa-miR-519d-5p	84.0958	NM_138348
OTULIN	hsa-miR-4677-5p	83.6015	NM_138348
OTULIN	hsa-miR-4481	83.3577	NM_138348
OTULIN	hsa-miR-4776-5p	83.276	NM_138348
OTULIN	hsa-miR-194-5p	82.4819	NM_138348
OTULIN	hsa-miR-10526-3p	82.2847	NM_138348
OTULIN	hsa-miR-767-5p	81.9976	NM_138348
OTULIN	hsa-miR-4668-5p	81.0827	NM_138348
OTULIN	hsa-miR-12136	80.9589	NM_138348
OTULIN	hsa-miR-3059-5p	80.34	NM_138348

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Motifs and transcription factors (TFs) regulating OTULIN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OTULIN	taipale_tf_pairs__HOXB2_SOX15_ACAAWRSNNNNYMATTA_CAP_repr	HOXB2; SOX15 (directAnnotation).
OTULIN	cisbp__M00788	ZFY (inferredBy_Orthology).
OTULIN	metacluster_7.13	ZFX (directAnnotation).
OTULIN	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
OTULIN	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
OTULIN	hdpi__HIP2	UBE2K (directAnnotation).
OTULIN	transfac_pro__M02913	SP140 (inferredBy_Orthology).
OTULIN	transfac_pro__M02898	SMAD3 (directAnnotation).
OTULIN	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
OTULIN	metacluster_191.5	SPDEF (inferredBy_Orthology).
OTULIN	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
OTULIN	hdpi__TIMELESS	TIMELESS (directAnnotation).
OTULIN	transfac_pro__M04893	TAF1 (directAnnotation).
OTULIN	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
OTULIN	hdpi__ZNF304	ZNF304 (directAnnotation).
OTULIN	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
OTULIN	transfac_pro__M00938	E2F1 (directAnnotation).
OTULIN	cisbp__M01863	ZNF711 (inferredBy_Orthology).
OTULIN	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
OTULIN	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
OTULIN	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
OTULIN	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
OTULIN	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
OTULIN	transfac_pro__M01199	TRIM28 (directAnnotation).
OTULIN	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
OTULIN	hdpi__ELF2	ELF2 (directAnnotation).
OTULIN	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
OTULIN	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
OTULIN	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
OTULIN	jaspar__MA1122.1	TFDP1 (directAnnotation).
OTULIN	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
OTULIN	transfac_pro__M01253	CNOT3 (directAnnotation).
OTULIN	transfac_pro__M02090	E2F4 (directAnnotation).
OTULIN	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
OTULIN	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
OTULIN	metacluster_163.2	ZNF682 (directAnnotation).
OTULIN	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
OTULIN	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
OTULIN	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
OTULIN	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
OTULIN	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
OTULIN	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
OTULIN	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
OTULIN	metacluster_160.20	JUND; PRDM15 (directAnnotation).
OTULIN	transfac_pro__M04817	ZBTB33 (directAnnotation).
OTULIN	transfac_pro__M05478	ZNF202 (directAnnotation).
OTULIN	metacluster_35.4	ETV4; ETV4; ETV5; SPI1 (directAnnotation).
OTULIN	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."