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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OTUD7B

Summary for OTUD7B

Gene information	Gene symbol	OTUD7B
	Ensembl ID	ENSG00000264522
	Entrez ID	56957
	Gene name	OTU deubiquitinase 7B
	Synonyms	CEZANNE\|ZA20D1
	Gene type	protein_coding
	UniProtAcc	Q6GQQ9

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Dataset with differentially expressed gene: OTUD7B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.251442	7.06e-21

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Expression of OTUD7B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OTUD7B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OTUD7B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OTUD7B	hsa-miR-95-5p	98.9687	NM_020205
OTUD7B	hsa-miR-6807-5p	96.879	NM_020205
OTUD7B	hsa-miR-548x-3p	94.5404	NM_020205
OTUD7B	hsa-miR-548aj-3p	94.5404	NM_020205
OTUD7B	hsa-miR-12136	94.4882	NM_020205
OTUD7B	hsa-miR-153-5p	94.2689	NM_020205
OTUD7B	hsa-miR-129-5p	94.2335	NM_020205
OTUD7B	hsa-miR-9983-3p	93.7995	NM_020205
OTUD7B	hsa-miR-548bb-3p	93.5892	NM_020205
OTUD7B	hsa-miR-548z	93.5892	NM_020205
OTUD7B	hsa-miR-548d-3p	93.5892	NM_020205
OTUD7B	hsa-miR-548h-3p	93.5892	NM_020205
OTUD7B	hsa-miR-548ac	93.5892	NM_020205
OTUD7B	hsa-miR-6124	93.3754	NM_020205
OTUD7B	hsa-miR-19b-3p	93.2838	NM_020205
OTUD7B	hsa-miR-19a-3p	93.2838	NM_020205
OTUD7B	hsa-miR-548am-3p	92.0383	NM_020205
OTUD7B	hsa-miR-548aq-3p	92.0383	NM_020205
OTUD7B	hsa-miR-548j-3p	92.0383	NM_020205
OTUD7B	hsa-miR-548ah-3p	92.0383	NM_020205
OTUD7B	hsa-miR-548ae-3p	92.0383	NM_020205
OTUD7B	hsa-miR-4325	92.0166	NM_020205
OTUD7B	hsa-miR-6749-3p	91.8051	NM_020205
OTUD7B	hsa-miR-9-5p	91.767	NM_020205
OTUD7B	hsa-miR-1910-5p	91.1192	NM_020205
OTUD7B	hsa-miR-766-5p	91.0621	NM_020205
OTUD7B	hsa-miR-6796-3p	90.7724	NM_020205
OTUD7B	hsa-miR-5688	90.5387	NM_020205
OTUD7B	hsa-miR-3148	90.3268	NM_020205
OTUD7B	hsa-miR-4446-5p	90.1804	NM_020205
OTUD7B	hsa-miR-495-3p	89.9876	NM_020205
OTUD7B	hsa-miR-519b-3p	89.1305	NM_020205
OTUD7B	hsa-miR-519c-3p	89.1305	NM_020205
OTUD7B	hsa-miR-519a-3p	89.1305	NM_020205
OTUD7B	hsa-miR-3133	88.9368	NM_020205
OTUD7B	hsa-miR-4282	88.1569	NM_020205
OTUD7B	hsa-miR-3679-3p	86.5206	NM_020205
OTUD7B	hsa-miR-4804-3p	85.7455	NM_020205
OTUD7B	hsa-miR-548as-3p	85.104	NM_020205
OTUD7B	hsa-miR-153-3p	85.0398	NM_020205
OTUD7B	hsa-miR-4533	84.8594	NM_020205
OTUD7B	hsa-miR-3613-3p	84.22	NM_020205
OTUD7B	hsa-miR-624-3p	83.8191	NM_020205
OTUD7B	hsa-miR-6826-3p	83.0984	NM_020205
OTUD7B	hsa-miR-3160-5p	83.0143	NM_020205
OTUD7B	hsa-miR-6887-3p	82.7541	NM_020205
OTUD7B	hsa-miR-8485	82.5601	NM_020205
OTUD7B	hsa-miR-137-3p	82.461	NM_020205
OTUD7B	hsa-miR-9-3p	82.1297	NM_020205
OTUD7B	hsa-miR-2467-3p	81.924	NM_020205

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Motifs and transcription factors (TFs) regulating OTUD7B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OTUD7B	metacluster_7.13	ZFX (directAnnotation).
OTUD7B	cisbp__M01863	ZNF711 (inferredBy_Orthology).
OTUD7B	metacluster_151.2	ZNF23 (directAnnotation).
OTUD7B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
OTUD7B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
OTUD7B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
OTUD7B	hdpi__ETV4	ETV4 (directAnnotation).
OTUD7B	transfac_pro__M05628	ZNF735 (directAnnotation).
OTUD7B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
OTUD7B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
OTUD7B	jaspar__MA0079.5	SP1 (directAnnotation).
OTUD7B	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."