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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OTUD1

Summary for OTUD1

Gene information	Gene symbol	OTUD1
	Ensembl ID	ENSG00000165312
	Entrez ID	220213
	Gene name	OTU deubiquitinase 1
	Synonyms	DUBA7\|OTDC1
	Gene type	protein_coding
	UniProtAcc	Q5VV17

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Dataset with differentially expressed gene: OTUD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.505331	5.29e-12
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.585326	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.641882	1.45e-14
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.304216	7.64e-10
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.447825	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.271404	1.06e-38
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.772541	0.00e+00

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Expression of OTUD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OTUD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OTUD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OTUD1	hsa-let-7c-3p	99.1369	NM_001145373
OTUD1	hsa-miR-548n	97.3854	NM_001145373
OTUD1	hsa-miR-4698	97.362	NM_001145373
OTUD1	hsa-miR-548aw	96.6736	NM_001145373
OTUD1	hsa-miR-3120-3p	95.8012	NM_001145373
OTUD1	hsa-miR-545-3p	95.611	NM_001145373
OTUD1	hsa-miR-4327	95.6064	NM_001145373
OTUD1	hsa-miR-3910	94.6372	NM_001145373
OTUD1	hsa-miR-877-3p	94.2098	NM_001145373
OTUD1	hsa-miR-3613-3p	93.705	NM_001145373
OTUD1	hsa-miR-4490	93.3887	NM_001145373
OTUD1	hsa-miR-12123	93.1541	NM_001145373
OTUD1	hsa-miR-5692a	93.0636	NM_001145373
OTUD1	hsa-miR-188-5p	91.8489	NM_001145373
OTUD1	hsa-miR-6866-3p	91.8489	NM_001145373
OTUD1	hsa-miR-19a-3p	91.6226	NM_001145373
OTUD1	hsa-miR-19b-3p	91.6226	NM_001145373
OTUD1	hsa-miR-3148	90.417	NM_001145373
OTUD1	hsa-miR-4694-3p	89.9602	NM_001145373
OTUD1	hsa-miR-548t-3p	88.8533	NM_001145373
OTUD1	hsa-miR-548ap-3p	88.8533	NM_001145373
OTUD1	hsa-miR-548aa	88.8533	NM_001145373
OTUD1	hsa-let-7f-2-3p	88.8346	NM_001145373
OTUD1	hsa-miR-1185-1-3p	88.8346	NM_001145373
OTUD1	hsa-miR-1185-2-3p	88.8346	NM_001145373
OTUD1	hsa-miR-5186	87.9517	NM_001145373
OTUD1	hsa-miR-6839-5p	87.5943	NM_001145373
OTUD1	hsa-miR-4796-3p	87.2648	NM_001145373
OTUD1	hsa-miR-543	86.7739	NM_001145373
OTUD1	hsa-miR-3191-5p	86.7031	NM_001145373
OTUD1	hsa-miR-518c-5p	86.519	NM_001145373
OTUD1	hsa-miR-6508-5p	85.7332	NM_001145373
OTUD1	hsa-miR-548l	85.5625	NM_001145373
OTUD1	hsa-miR-378j	85.3916	NM_001145373
OTUD1	hsa-miR-3688-3p	84.7447	NM_001145373
OTUD1	hsa-miR-147b-5p	84.5611	NM_001145373
OTUD1	hsa-miR-153-5p	84.2929	NM_001145373
OTUD1	hsa-miR-3680-3p	84.2456	NM_001145373
OTUD1	hsa-miR-1298-5p	83.8973	NM_001145373
OTUD1	hsa-miR-518a-5p	83.1907	NM_001145373
OTUD1	hsa-miR-527	83.1907	NM_001145373
OTUD1	hsa-miR-4261	82.9152	NM_001145373
OTUD1	hsa-miR-499b-5p	82.798	NM_001145373
OTUD1	hsa-miR-4801	82.7237	NM_001145373
OTUD1	hsa-miR-4731-3p	82.7237	NM_001145373
OTUD1	hsa-miR-6715a-3p	82.6125	NM_001145373
OTUD1	hsa-miR-4262	82.3805	NM_001145373
OTUD1	hsa-miR-20a-3p	82.2077	NM_001145373
OTUD1	hsa-miR-1976	81.9199	NM_001145373
OTUD1	hsa-miR-515-5p	81.6986	NM_001145373

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Motifs and transcription factors (TFs) regulating OTUD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OTUD1	transfac_pro__M05667	ZNF35 (directAnnotation).
OTUD1	taipale_tf_pairs__MYBL1_TBX21_AGGTGTGNCSGTTR_CAP_repr	MYBL1; TBX21 (directAnnotation).
OTUD1	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
OTUD1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
OTUD1	transfac_pro__M06340	ZNF790 (directAnnotation).
OTUD1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
OTUD1	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
OTUD1	metacluster_14.11	MITF; TFE3 (inferredBy_Orthology).
OTUD1	transfac_pro__M04746	E2F1 (directAnnotation).
OTUD1	metacluster_167.7	IRF8 (inferredBy_Orthology).
OTUD1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
OTUD1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
OTUD1	transfac_pro__M04722	SPI1 (directAnnotation).
OTUD1	cisbp__M04023	CREB1 (directAnnotation).
OTUD1	jaspar__MA0039.4	KLF4 (directAnnotation).
OTUD1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
OTUD1	transfac_pro__M04595	SALL2 (directAnnotation).
OTUD1	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
OTUD1	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).
OTUD1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
OTUD1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
OTUD1	transfac_pro__M02089	E2F3 (directAnnotation).
OTUD1	transfac_pro__M02898	SMAD3 (directAnnotation).
OTUD1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
OTUD1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
OTUD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
OTUD1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
OTUD1	hdpi__HIP2	UBE2K (directAnnotation).
OTUD1	hdpi__NRL	NRL (directAnnotation).
OTUD1	transfac_pro__M00430	E2F1 (directAnnotation).
OTUD1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
OTUD1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
OTUD1	transfac_pro__M07329	SP7 (directAnnotation).
OTUD1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
OTUD1	transfac_pro__M07397	ZNF148 (directAnnotation).
OTUD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
OTUD1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
OTUD1	cisbp__M07938	E2F1 (directAnnotation).
OTUD1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
OTUD1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
OTUD1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
OTUD1	transfac_pro__M07436	WT1 (directAnnotation).
OTUD1	metacluster_3.14	WT1; WT1 (directAnnotation).
OTUD1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
OTUD1	transfac_pro__M01837	KLF11 (directAnnotation).
OTUD1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
OTUD1	transfac_pro__M07310	SP5 (directAnnotation).
OTUD1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
OTUD1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
OTUD1	transfac_pro__M04817	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."