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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OSTC

Summary for OSTC

Gene information	Gene symbol	OSTC
	Ensembl ID	ENSG00000198856
	Entrez ID	58505
	Gene name	oligosaccharyltransferase complex non-catalytic subunit
	Synonyms	DC2
	Gene type	protein_coding
	UniProtAcc	Q9NRP0

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Dataset with differentially expressed gene: OSTC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.564662	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.310521	6.61e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.334156	1.19e-05
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.66558	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.303991	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.678389	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.745635	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.477589	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.425635	9.13e-40
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.383517	5.41e-20
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.558971	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.352021	1.17e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.572425	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.439236	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.623639	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.494676	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.355861	0.00e+00

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Expression of OSTC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OSTC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OSTC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OSTC	hsa-miR-519d-5p	95.9474	NM_001267818
OSTC	hsa-miR-498-3p	95.0838	NM_001267818
OSTC	hsa-miR-519e-5p	93.7222	NM_001267818
OSTC	hsa-miR-515-5p	93.7222	NM_001267818
OSTC	hsa-miR-29a-3p	92.076	NM_001267818
OSTC	hsa-miR-29b-3p	92.076	NM_001267818
OSTC	hsa-miR-29c-3p	92.076	NM_001267818
OSTC	hsa-miR-6839-5p	90.5637	NM_021227
OSTC	hsa-miR-378j	88.9996	NM_021227
OSTC	hsa-miR-6787-3p	88.924	NM_001267818
OSTC	hsa-miR-3692-3p	88.8402	NM_021227
OSTC	hsa-miR-6818-3p	86.4187	NM_021227
OSTC	hsa-miR-6828-3p	85.6542	NM_021227
OSTC	hsa-miR-181a-2-3p	83.6898	NM_021227
OSTC	hsa-miR-767-5p	82.8416	NM_001267818
OSTC	hsa-miR-6835-3p	82.2181	NM_001267818
OSTC	hsa-miR-4782-5p	81.9272	NM_021227
OSTC	hsa-miR-5706	81.9272	NM_021227
OSTC	hsa-miR-1290	80.9983	NM_021227
OSTC	hsa-miR-877-5p	80.7734	NM_021227
OSTC	hsa-miR-34b-3p	80.643	NM_021227

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Motifs and transcription factors (TFs) regulating OSTC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OSTC	hdpi__ETV4	ETV4 (directAnnotation).
OSTC	cisbp__M02645	ETS1 (directAnnotation).
OSTC	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
OSTC	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
OSTC	jaspar__MA1483.2	ELF2 (directAnnotation).
OSTC	cisbp__M08198	ELF1 (directAnnotation).
OSTC	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
OSTC	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
OSTC	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
OSTC	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
OSTC	swissregulon__hs__ETV6	ETV6 (directAnnotation).
OSTC	metacluster_33.5	MTF1 (inferredBy_Orthology).
OSTC	transfac_pro__M04848	TAF1 (directAnnotation).
OSTC	transfac_pro__M05670	ZNF37A (directAnnotation).
OSTC	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
OSTC	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
OSTC	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
OSTC	transfac_pro__M04748	GABPA (directAnnotation).
OSTC	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
OSTC	hdpi__TP73	TP73 (directAnnotation).
OSTC	transfac_public__M00024	E2F1 (directAnnotation).
OSTC	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
OSTC	transfac_pro__M04826	EP300 (directAnnotation).
OSTC	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
OSTC	transfac_pro__M04950	EGR1 (directAnnotation).
OSTC	transfac_pro__M04862	NRF1 (directAnnotation).
OSTC	transfac_pro__M00652	NRF1 (directAnnotation).
OSTC	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
OSTC	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
OSTC	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
OSTC	transfac_pro__M01298	MECP2 (directAnnotation).
OSTC	hdpi__FLI1	FLI1 (directAnnotation).
OSTC	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
OSTC	metacluster_198.3	ZFP64 (directAnnotation).
OSTC	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
OSTC	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
OSTC	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
OSTC	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
OSTC	jaspar__MA1708.1	ETV7 (directAnnotation).
OSTC	hdpi__ELF2	ELF2 (directAnnotation).
OSTC	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
OSTC	jaspar__MA0502.2	NFYB (directAnnotation).
OSTC	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
OSTC	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
OSTC	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
OSTC	transfac_pro__M06135	ZNF28 (directAnnotation).
OSTC	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
OSTC	taipale_tf_pairs__SOX6_TBX21_RGGTGTNNNNNNNNNYATTGT_CAP_repr	SOX6; TBX21 (directAnnotation).
OSTC	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
OSTC	swissregulon__hs__OVOL1	OVOL1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."