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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OSM

Summary for OSM

Gene information	Gene symbol	OSM
	Ensembl ID	ENSG00000099985
	Entrez ID	5008
	Gene name	oncostatin M
	Synonyms	MGC20461
	Gene type	protein_coding
	UniProtAcc	P13725

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Dataset with differentially expressed gene: OSM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.514985	1.36e-35
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.784097	1.39e-22

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Expression of OSM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OSM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
OSM	Neutrophils	CPI-SC0CDC669B3	OSM_LIFR	OSM	NA	False	Neutrophils	Endothelial cells	GSE207422_Tor	post	resistant
OSM	Neutrophils	CPI-SC04DB1BDAB	OSM_OSMR	OSM	NA	False	Neutrophils	Endothelial cells	GSE207422_Tor	post	resistant
OSM	Neutrophils	CPI-SC04DB1BDAB	OSM_OSMR	OSM	NA	False	Neutrophils	Fibroblasts	GSE207422_Tor	post	resistant
OSM	Neutrophils	CPI-SC04DB1BDAB	OSM_OSMR	OSM	NA	False	Neutrophils	Malignant cells	GSE207422_Tor	post	resistant
OSM	Neutrophils	CPI-SC0CDC669B3	OSM_LIFR	OSM	NA	False	Neutrophils	Endothelial cells	GSE207422_Tor	post	sensitive
OSM	Neutrophils	CPI-SC04DB1BDAB	OSM_OSMR	OSM	NA	False	Neutrophils	Endothelial cells	GSE207422_Tor	post	sensitive
OSM	Neutrophils	CPI-SC04DB1BDAB	OSM_OSMR	OSM	NA	False	Neutrophils	Fibroblasts	GSE207422_Tor	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OSM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OSM	hsa-miR-548ar-3p	94.2164	NM_001319108
OSM	hsa-miR-3143	94.0906	NM_001319108
OSM	hsa-miR-548e-3p	93.8628	NM_001319108
OSM	hsa-miR-548az-3p	93.8628	NM_001319108
OSM	hsa-miR-548a-3p	93.8628	NM_001319108
OSM	hsa-miR-548bc	93.8628	NM_001319108
OSM	hsa-miR-548f-3p	93.8628	NM_001319108
OSM	hsa-miR-106b-5p	92.1938	NM_001319108
OSM	hsa-miR-20a-5p	92.1938	NM_001319108
OSM	hsa-miR-1911-3p	89.6652	NM_001319108
OSM	hsa-miR-526b-3p	88.4265	NM_001319108
OSM	hsa-miR-519d-3p	88.4265	NM_001319108
OSM	hsa-miR-17-5p	88.4265	NM_001319108
OSM	hsa-miR-20b-5p	88.4265	NM_001319108
OSM	hsa-miR-93-5p	88.4265	NM_001319108
OSM	hsa-miR-106a-5p	88.4265	NM_001319108
OSM	hsa-miR-5187-3p	88.3832	NM_001319108
OSM	hsa-miR-6882-3p	87.0051	NM_001319108
OSM	hsa-miR-6891-5p	86.4874	NM_001319108
OSM	hsa-miR-3173-3p	86.4874	NM_001319108
OSM	hsa-miR-12118	86.4874	NM_001319108
OSM	hsa-miR-507	84.9486	NM_001319108
OSM	hsa-miR-302c-5p	82.446	NM_001319108
OSM	hsa-miR-4796-3p	81.7648	NM_001319108

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Motifs and transcription factors (TFs) regulating OSM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OSM	metacluster_22.34	BACH2 (directAnnotation).
OSM	metacluster_22.33	MAFK (inferredBy_Orthology).
OSM	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
OSM	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
OSM	metacluster_111.5	E4F1; E4F1 (directAnnotation).
OSM	kznf__CTCF_Rhee2011.3_ChIP-exo	CTCF (directAnnotation).
OSM	transfac_pro__M01239	RELA (directAnnotation).
OSM	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
OSM	metacluster_187.8	ZNF22 (directAnnotation).
OSM	transfac_pro__M05905	ZNF649 (directAnnotation).
OSM	tfdimers__MD00521	CHURC1; TAF6; TBP (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."