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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OSBPL11

Summary for OSBPL11

Gene information	Gene symbol	OSBPL11
	Ensembl ID	ENSG00000144909
	Entrez ID	114885
	Gene name	oxysterol binding protein like 11
	Synonyms	FLJ13012\|FLJ13164\|ORP-11\|ORP11
	Gene type	protein_coding
	UniProtAcc	Q9BXB4

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Dataset with differentially expressed gene: OSBPL11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.329303	1.37e-10

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Expression of OSBPL11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OSBPL11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OSBPL11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OSBPL11	hsa-miR-498-5p	99.3161	NM_022776
OSBPL11	hsa-miR-1297	99.2899	NM_022776
OSBPL11	hsa-miR-26a-5p	99.1427	NM_022776
OSBPL11	hsa-miR-26b-5p	99.1427	NM_022776
OSBPL11	hsa-miR-4465	99.0007	NM_022776
OSBPL11	hsa-miR-148b-3p	98.0868	NM_022776
OSBPL11	hsa-miR-152-3p	97.4762	NM_022776
OSBPL11	hsa-miR-148a-3p	97.4762	NM_022776
OSBPL11	hsa-miR-4257	97.3165	NM_022776
OSBPL11	hsa-miR-1243	97.0716	NM_022776
OSBPL11	hsa-miR-3663-3p	96.8591	NM_022776
OSBPL11	hsa-miR-3907	96.7576	NM_022776
OSBPL11	hsa-miR-29a-3p	95.2329	NM_022776
OSBPL11	hsa-miR-29c-3p	95.2329	NM_022776
OSBPL11	hsa-miR-29b-3p	95.2329	NM_022776
OSBPL11	hsa-miR-888-3p	95.0347	NM_022776
OSBPL11	hsa-miR-6768-5p	94.8351	NM_022776
OSBPL11	hsa-miR-466	94.688	NM_022776
OSBPL11	hsa-miR-545-3p	93.1825	NM_022776
OSBPL11	hsa-miR-1279	92.9245	NM_022776
OSBPL11	hsa-miR-133a-3p	92.5029	NM_022776
OSBPL11	hsa-miR-133b	92.5029	NM_022776
OSBPL11	hsa-miR-200a-3p	91.5546	NM_022776
OSBPL11	hsa-miR-141-3p	91.5546	NM_022776
OSBPL11	hsa-miR-4276	91.3375	NM_022776
OSBPL11	hsa-miR-224-5p	91.0227	NM_022776
OSBPL11	hsa-miR-299-5p	90.592	NM_022776
OSBPL11	hsa-miR-767-5p	90.5603	NM_022776
OSBPL11	hsa-miR-1305	90.4196	NM_022776
OSBPL11	hsa-miR-7-5p	89.8597	NM_022776
OSBPL11	hsa-miR-6501-3p	89.5636	NM_022776
OSBPL11	hsa-miR-3972	89.439	NM_022776
OSBPL11	hsa-miR-1202	89.439	NM_022776
OSBPL11	hsa-miR-5697	88.9557	NM_022776
OSBPL11	hsa-miR-653-5p	88.1759	NM_022776
OSBPL11	hsa-miR-429	88.1231	NM_022776
OSBPL11	hsa-miR-200c-3p	88.1231	NM_022776
OSBPL11	hsa-miR-200b-3p	88.1231	NM_022776
OSBPL11	hsa-miR-4789-3p	87.9242	NM_022776
OSBPL11	hsa-miR-670-3p	87.6851	NM_022776
OSBPL11	hsa-miR-6502-3p	87.5607	NM_022776
OSBPL11	hsa-miR-6715b-5p	87.0774	NM_022776
OSBPL11	hsa-miR-4269	87.0774	NM_022776
OSBPL11	hsa-miR-6895-3p	86.0677	NM_022776
OSBPL11	hsa-miR-506-3p	85.7896	NM_022776
OSBPL11	hsa-miR-124-3p	85.7896	NM_022776
OSBPL11	hsa-miR-6513-3p	85.5364	NM_022776
OSBPL11	hsa-miR-30d-3p	85.1922	NM_022776
OSBPL11	hsa-miR-30e-3p	85.1922	NM_022776
OSBPL11	hsa-miR-30a-3p	85.1922	NM_022776

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Motifs and transcription factors (TFs) regulating OSBPL11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OSBPL11	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
OSBPL11	jaspar__MA1633.2	BACH1 (directAnnotation).
OSBPL11	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."