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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ORAI2

Summary for ORAI2

Gene information	Gene symbol	ORAI2
	Ensembl ID	ENSG00000160991
	Entrez ID	80228
	Gene name	ORAI calcium release-activated calcium modulator 2
	Synonyms	C7orf19\|CBCIP2\|FLJ12474\|FLJ14733\|H_NH0514P08.8\|TMEM142B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ORAI2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.305885	7.39e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.269148	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.499973	2.97e-25
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.405838	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.310554	0.00e+00

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Expression of ORAI2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ORAI2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ORAI2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ORAI2	hsa-miR-6778-3p	99.9632	NM_001126340
ORAI2	hsa-miR-4755-3p	98.7706	NM_001126340
ORAI2	hsa-miR-4728-5p	97.327	NM_001126340
ORAI2	hsa-miR-7106-5p	97.0154	NM_001126340
ORAI2	hsa-miR-520b-5p	96.1755	NM_001126340
ORAI2	hsa-miR-519a-2-5p	96.1755	NM_001126340
ORAI2	hsa-miR-6785-5p	96.0723	NM_001126340
ORAI2	hsa-miR-6849-3p	95.3679	NM_001126340
ORAI2	hsa-miR-149-3p	94.5841	NM_001126340
ORAI2	hsa-miR-6747-3p	94.523	NM_001126340
ORAI2	hsa-miR-6780a-5p	94.3863	NM_001126340
ORAI2	hsa-miR-1273h-5p	94.2897	NM_001126340
ORAI2	hsa-miR-4640-5p	94.1983	NM_001126340
ORAI2	hsa-miR-1184	93.833	NM_001126340
ORAI2	hsa-miR-4478	93.8322	NM_001126340
ORAI2	hsa-miR-3689b-3p	93.4618	NM_001126340
ORAI2	hsa-miR-3689c	93.4618	NM_001126340
ORAI2	hsa-miR-6779-5p	93.4618	NM_001126340
ORAI2	hsa-miR-30b-3p	93.4618	NM_001126340
ORAI2	hsa-miR-3689a-3p	93.4618	NM_001126340
ORAI2	hsa-miR-4684-5p	93.0676	NM_001126340
ORAI2	hsa-miR-5589-5p	92.9685	NM_001126340
ORAI2	hsa-miR-939-3p	92.5955	NM_001126340
ORAI2	hsa-miR-6883-5p	92.2098	NM_001126340
ORAI2	hsa-miR-1207-5p	91.9802	NM_001126340
ORAI2	hsa-miR-4731-5p	91.9486	NM_001126340
ORAI2	hsa-miR-4726-5p	91.9239	NM_001126340
ORAI2	hsa-miR-4649-3p	91.8034	NM_001126340
ORAI2	hsa-miR-4763-3p	91.3017	NM_001126340
ORAI2	hsa-miR-5787	90.8868	NM_001126340
ORAI2	hsa-miR-3135b	90.7517	NM_001126340
ORAI2	hsa-miR-3187-5p	89.2896	NM_001126340
ORAI2	hsa-miR-619-5p	89.2411	NM_001126340
ORAI2	hsa-miR-4646-5p	89.067	NM_001126340
ORAI2	hsa-miR-6799-5p	89.0527	NM_001126340
ORAI2	hsa-miR-6829-3p	88.6311	NM_001126340
ORAI2	hsa-miR-6791-3p	88.6311	NM_001126340
ORAI2	hsa-miR-486-3p	88.5945	NM_001126340
ORAI2	hsa-miR-204-3p	88.568	NM_001126340
ORAI2	hsa-miR-4505	88.4821	NM_001126340
ORAI2	hsa-miR-450a-2-3p	88.2	NM_001126340
ORAI2	hsa-miR-4283	88.1844	NM_001126340
ORAI2	hsa-miR-3664-3p	87.323	NM_001126340
ORAI2	hsa-miR-6837-5p	87.1851	NM_001126340
ORAI2	hsa-miR-504-3p	86.975	NM_001126340
ORAI2	hsa-miR-6512-3p	86.8763	NM_001126340
ORAI2	hsa-miR-6720-5p	86.8763	NM_001126340
ORAI2	hsa-miR-150-5p	86.6866	NM_001126340
ORAI2	hsa-miR-7977	86.3492	NM_001126340
ORAI2	hsa-miR-660-3p	85.9152	NM_001126340

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Motifs and transcription factors (TFs) regulating ORAI2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ORAI2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ORAI2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ORAI2	jaspar__MA0079.5	SP1 (directAnnotation).
ORAI2	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
ORAI2	tfdimers__MD00151	CHURC1 (directAnnotation).
ORAI2	transfac_public__M00491	PATZ1 (directAnnotation).
ORAI2	metacluster_3.14	WT1; WT1 (directAnnotation).
ORAI2	transfac_pro__M07387	ZBTB7A (directAnnotation).
ORAI2	transfac_pro__M00986	CHURC1 (directAnnotation).
ORAI2	transfac_pro__M01714	KLF15 (directAnnotation).
ORAI2	cisbp__M00341	PAX6 (directAnnotation).
ORAI2	swissregulon__hs__PATZ1	PATZ1 (directAnnotation).
ORAI2	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
ORAI2	metacluster_177.7	ZBTB18; ZBTB18; ZBTB18; ZBTB42 (directAnnotation).
ORAI2	kznf__ZNF26_Imbeault2017_OM_MEME	ZNF26 (directAnnotation).
ORAI2	taipale_tf_pairs__GCM1_FOXI1_TGTTGANGCGGGN_CAP	FOXI1; GCM1 (directAnnotation).
ORAI2	kznf__ZNF669_Najafabadi2015_ChIP-seq	ZNF669 (directAnnotation).
ORAI2	metacluster_141.2	E2F2; E2F3 (directAnnotation).
ORAI2	tfdimers__MD00553	FOXG1; FOXO1; RUNX3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."