Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OPTN

Summary for OPTN

Gene information	Gene symbol	OPTN
	Ensembl ID	ENSG00000123240
	Entrez ID	10133
	Gene name	optineurin
	Synonyms	FIP-2\|FIP2\|GLC1E\|HIP7\|HYPL\|NRP\|TFIIIA-INTP
	Gene type	protein_coding
	UniProtAcc	Q96CV9

Top

Dataset with differentially expressed gene: OPTN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.504007	3.34e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.329129	1.51e-07
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.282481	6.98e-14
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.269893	4.07e-06
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.317088	5.10e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.435649	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.313871	6.81e-16

Top

Expression of OPTN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to OPTN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating OPTN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OPTN	hsa-miR-361-5p	93.5357	NM_001008212
OPTN	hsa-miR-1468-3p	86.7663	NM_001008211
OPTN	hsa-miR-3682-3p	86.3904	NM_001008212
OPTN	hsa-miR-27b-5p	85.8915	NM_001008212
OPTN	hsa-miR-10527-5p	84.3229	NM_001008212
OPTN	hsa-miR-570-3p	82.119	NM_001008212

Page: 1

Top

Motifs and transcription factors (TFs) regulating OPTN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OPTN	metacluster_7.13	ZFX (directAnnotation).
OPTN	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
OPTN	metacluster_151.2	ZNF23 (directAnnotation).
OPTN	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
OPTN	transfac_pro__M05479	ZNF580 (directAnnotation).
OPTN	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
OPTN	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
OPTN	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
OPTN	jaspar__MA0079.5	SP1 (directAnnotation).
OPTN	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
OPTN	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
OPTN	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
OPTN	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
OPTN	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
OPTN	metacluster_131.1	ZNF398 (directAnnotation).
OPTN	transfac_pro__M05572	ZFP91; ZFP91-CNTF (inferredBy_Orthology).
OPTN	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
OPTN	taipale_tf_pairs__TEAD4_DRGX_GGAATGTTAATTR_CAP	DRGX; TEAD4 (directAnnotation).
OPTN	transfac_pro__M06601	ZNF501 (directAnnotation).
OPTN	transfac_pro__M06111	ZNF254 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."