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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OPA3

Summary for OPA3

Gene information	Gene symbol	OPA3
	Ensembl ID	ENSG00000125741
	Entrez ID	80207
	Gene name	outer mitochondrial membrane lipid metabolism regulator OPA3
	Synonyms	FLJ22187\|MGA3
	Gene type	protein_coding
	UniProtAcc	Q9H6K4

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Dataset with differentially expressed gene: OPA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.294243	0.00e+00

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Expression of OPA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OPA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OPA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OPA3	hsa-miR-4739	97.8458	NM_001017989
OPA3	hsa-miR-1321	97.8206	NM_001017989
OPA3	hsa-miR-4756-5p	97.8206	NM_001017989
OPA3	hsa-miR-6747-3p	96.2702	NM_025136
OPA3	hsa-miR-597-5p	93.816	NM_025136
OPA3	hsa-miR-376c-3p	93.4126	NM_025136
OPA3	hsa-miR-4447	93.2814	NM_025136
OPA3	hsa-miR-6778-3p	93.025	NM_025136
OPA3	hsa-miR-4458	91.211	NM_001017989
OPA3	hsa-miR-4500	90.713	NM_001017989
OPA3	hsa-miR-4643	89.0868	NM_025136
OPA3	hsa-miR-10395-3p	88.7561	NM_025136
OPA3	hsa-miR-98-5p	88.5319	NM_001017989
OPA3	hsa-let-7a-5p	88.5319	NM_001017989
OPA3	hsa-let-7g-5p	88.5319	NM_001017989
OPA3	hsa-let-7f-5p	88.5319	NM_001017989
OPA3	hsa-let-7b-5p	88.5319	NM_001017989
OPA3	hsa-let-7c-5p	88.5319	NM_001017989
OPA3	hsa-let-7i-5p	88.5319	NM_001017989
OPA3	hsa-let-7e-5p	88.5319	NM_001017989
OPA3	hsa-miR-6504-3p	88.4405	NM_025136
OPA3	hsa-miR-4426	87.6079	NM_001017989
OPA3	hsa-miR-4472	87.0069	NM_025136
OPA3	hsa-miR-196b-5p	86.3368	NM_001017989
OPA3	hsa-miR-196a-5p	86.3368	NM_001017989
OPA3	hsa-let-7d-5p	86.275	NM_001017989
OPA3	hsa-miR-619-5p	86.2638	NM_025136
OPA3	hsa-miR-7151-3p	85.4491	NM_025136
OPA3	hsa-miR-12114	85.239	NM_001017989
OPA3	hsa-miR-5187-5p	84.2343	NM_025136
OPA3	hsa-miR-1207-5p	83.6659	NM_025136
OPA3	hsa-miR-659-5p	83.4951	NM_025136
OPA3	hsa-miR-4789-5p	83.011	NM_025136
OPA3	hsa-miR-6727-3p	82.6927	NM_025136
OPA3	hsa-miR-190b-5p	82.1723	NM_025136
OPA3	hsa-miR-190a-5p	82.1723	NM_025136
OPA3	hsa-miR-3652	81.587	NM_025136
OPA3	hsa-miR-4430	81.587	NM_025136
OPA3	hsa-miR-6506-5p	81.3519	NM_025136
OPA3	hsa-miR-568	80.9691	NM_025136
OPA3	hsa-miR-150-5p	80.7753	NM_025136
OPA3	hsa-miR-4722-3p	80.7544	NM_025136
OPA3	hsa-miR-4647	80.4294	NM_001017989
OPA3	hsa-miR-4662b	80.4294	NM_001017989
OPA3	hsa-miR-4279	80.2116	NM_025136
OPA3	hsa-miR-200a-3p	80.2014	NM_025136
OPA3	hsa-miR-141-3p	80.2014	NM_025136

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Motifs and transcription factors (TFs) regulating OPA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OPA3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
OPA3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
OPA3	transfac_pro__M04950	EGR1 (directAnnotation).
OPA3	transfac_pro__M04826	EP300 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."