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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OGT

Summary for OGT

Gene information	Gene symbol	OGT
	Ensembl ID	ENSG00000147162
	Entrez ID	8473
	Gene name	O-linked N-acetylglucosamine (GlcNAc) transferase
	Synonyms	FLJ23071\|HRNT1\|MGC22921\|O-GLCNAC\|OGT1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: OGT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.349141	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.2666	1.96e-42
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.283198	3.43e-08
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.370086	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.304549	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.279939	2.74e-04
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.323404	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.316907	7.24e-19

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Expression of OGT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OGT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
OGT	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating OGT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OGT	hsa-miR-7851-3p	98.7166	NM_181672
OGT	hsa-miR-548as-3p	98.2007	NM_181672
OGT	hsa-miR-4772-3p	98.041	NM_181672
OGT	hsa-miR-548aa	98.0146	NM_181672
OGT	hsa-miR-548ay-3p	98.0146	NM_181672
OGT	hsa-miR-548t-3p	98.0146	NM_181672
OGT	hsa-miR-548ap-3p	98.0146	NM_181672
OGT	hsa-miR-548at-3p	98.0146	NM_181672
OGT	hsa-miR-2467-5p	97.3578	NM_181672
OGT	hsa-miR-619-3p	97.0553	NM_181672
OGT	hsa-miR-548c-3p	96.9224	NM_181672
OGT	hsa-miR-485-5p	96.3603	NM_181672
OGT	hsa-miR-6884-5p	96.3603	NM_181672
OGT	hsa-miR-3975	95.4189	NM_181672
OGT	hsa-miR-664b-3p	95.1953	NM_181672
OGT	hsa-miR-579-3p	95.1953	NM_181672
OGT	hsa-miR-3188	94.054	NM_181672
OGT	hsa-miR-483-3p	94.0228	NM_181672
OGT	hsa-miR-361-3p	93.2212	NM_181672
OGT	hsa-miR-1264	92.2665	NM_181672
OGT	hsa-miR-5696	91.592	NM_181672
OGT	hsa-miR-9902	91.3617	NM_181672
OGT	hsa-miR-4729	90.9133	NM_181672
OGT	hsa-miR-202-5p	90.3236	NM_181672
OGT	hsa-miR-3692-3p	90.098	NM_181672
OGT	hsa-miR-3934-3p	90.0398	NM_181672
OGT	hsa-miR-7856-5p	89.9296	NM_181672
OGT	hsa-miR-96-5p	89.9248	NM_181672
OGT	hsa-miR-7974	89.5321	NM_181672
OGT	hsa-miR-1226-3p	89.195	NM_181672
OGT	hsa-miR-7-5p	89.0516	NM_181672
OGT	hsa-miR-3166	88.8654	NM_181672
OGT	hsa-miR-3978	88.7609	NM_181672
OGT	hsa-miR-340-5p	88.515	NM_181672
OGT	hsa-miR-1226-5p	88.4739	NM_181672
OGT	hsa-miR-9851-3p	88.464	NM_181672
OGT	hsa-miR-338-5p	88.3287	NM_181672
OGT	hsa-miR-12133	87.9809	NM_181672
OGT	hsa-miR-1271-5p	87.9809	NM_181672
OGT	hsa-miR-4266	86.8069	NM_181672
OGT	hsa-miR-6757-3p	86.4665	NM_181672
OGT	hsa-miR-593-5p	86.4404	NM_181672
OGT	hsa-miR-195-5p	86.3739	NM_181672
OGT	hsa-miR-16-5p	86.3739	NM_181672
OGT	hsa-miR-497-5p	86.3739	NM_181672
OGT	hsa-miR-6838-5p	86.3739	NM_181672
OGT	hsa-miR-15a-5p	86.3739	NM_181672
OGT	hsa-miR-15b-5p	86.3739	NM_181672
OGT	hsa-miR-424-5p	86.3739	NM_181672
OGT	hsa-miR-4768-3p	86.2585	NM_181672

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Motifs and transcription factors (TFs) regulating OGT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OGT	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
OGT	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
OGT	jaspar__MA0748.2	YY2 (directAnnotation).
OGT	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
OGT	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
OGT	metacluster_155.11	SPZ1 (directAnnotation).
OGT	hdpi__HTATIP2	HTATIP2 (directAnnotation).
OGT	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
OGT	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
OGT	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
OGT	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
OGT	hdpi__RARA	RARA (directAnnotation).
OGT	jaspar__MA1650.1	ZBTB14 (directAnnotation).
OGT	transfac_pro__M00938	E2F1 (directAnnotation).
OGT	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
OGT	metacluster_45.4	E2F2 (directAnnotation).
OGT	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
OGT	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
OGT	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
OGT	transfac_pro__M00430	E2F1 (directAnnotation).
OGT	jaspar__MA1721.1	ZNF93 (directAnnotation).
OGT	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
OGT	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
OGT	transfac_pro__M06331	ZNF343 (directAnnotation).
OGT	metacluster_141.4	GLIS2 (directAnnotation).
OGT	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
OGT	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
OGT	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
OGT	transfac_pro__M03844	ELK4 (directAnnotation).
OGT	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
OGT	taipale_tf_pairs__TEAD4_CEBPD_NTTRCGYAANNNNNNRGWATGY_CAP	CEBPD; TEAD4 (directAnnotation).
OGT	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
OGT	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
OGT	cisbp__M02645	ETS1 (directAnnotation).
OGT	hdpi__FLI1	FLI1 (directAnnotation).
OGT	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
OGT	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
OGT	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
OGT	kznf__ZNF135_Isakova2017_SMiLE-seq	ZNF135 (directAnnotation).
OGT	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
OGT	transfac_pro__M01660	GABPA (directAnnotation).
OGT	tfdimers__MD00045	STAT6; ZNF354C (directAnnotation).
OGT	transfac_pro__M06462	ZNF441 (directAnnotation).
OGT	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
OGT	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
OGT	transfac_pro__M06943	PBX3 (directAnnotation).
OGT	transfac_pro__M12556	ETV4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."