DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: OGN

Summary for OGN

Gene informationGene symbol

OGN

Ensembl ID

ENSG00000106809

Entrez ID

4969

Gene nameosteoglycin
Synonymsmimecan|OIF|SLRR3A
Gene typeprotein_coding
UniProtAcc

P20774


Top

Dataset with differentially expressed gene: OGN

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells-0.6286853.09e-02

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postFibroblasts-0.6665762.66e-04

Top

Expression of OGN in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to OGN

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating OGN

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
OGNhsa-miR-472996.2981NM_024416
OGNhsa-miR-129096.1804NM_024416
OGNhsa-miR-335-3p96.1719NM_014057
OGNhsa-miR-374a-3p94.5958NM_024416
OGNhsa-miR-569694.2415NM_024416
OGNhsa-miR-361-5p91.7514NM_024416
OGNhsa-miR-624-3p91.1994NM_014057
OGNhsa-miR-469891.009NM_024416
OGNhsa-miR-2681-5p90.6584NM_014057
OGNhsa-miR-379-5p90.5773NM_024416
OGNhsa-miR-494-3p89.7501NM_014057
OGNhsa-miR-94489.6568NM_024416
OGNhsa-miR-127989.4382NM_024416
OGNhsa-miR-15b-3p89.3287NM_024416
OGNhsa-miR-433089.2612NM_024416
OGNhsa-miR-3529-5p88.8184NM_024416
OGNhsa-miR-1213688.6318NM_024416
OGNhsa-miR-807087.8693NM_024416
OGNhsa-miR-20b-3p87.4104NM_024416
OGNhsa-miR-2115-3p87.1139NM_024416
OGNhsa-miR-22-3p86.4272NM_024416
OGNhsa-miR-5692a86.1747NM_024416
OGNhsa-miR-1252-3p86.0017NM_024416
OGNhsa-miR-7844-5p85.726NM_024416
OGNhsa-miR-3680-5p84.1889NM_024416
OGNhsa-miR-7158-3p83.0349NM_024416
OGNhsa-miR-4753-3p82.9063NM_024416
OGNhsa-miR-101-5p82.0229NM_024416
OGNhsa-miR-5003-3p81.7941NM_014057
OGNhsa-miR-608380.3214NM_024416
Page: 1

Top

Motifs and transcription factors (TFs) regulating OGN

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
OGNdbtfbs__ZBED5_HepG2_ENCSR656SIB_merged_N1ZBED5 (directAnnotation).
OGNtransfac_pro__M06070ZNF732 (directAnnotation).
OGNmetacluster_182.5HINFP (directAnnotation).
OGNtransfac_pro__M06789ZNF835 (directAnnotation).
OGNtransfac_pro__M06894ZFP90 (inferredBy_Orthology).
OGNtransfac_pro__M06516ZNF418 (directAnnotation).
OGNtransfac_pro__M06936MAFF (inferredBy_Orthology).
OGNtransfac_pro__M05601FIZ1 (directAnnotation).
OGNtaipale_tf_pairs__HOXB2_HOXB13_NNMATCACATAAAN_CAP_reprHOXB13; HOXB2 (directAnnotation).
OGNtransfac_pro__M06950HIF3A (inferredBy_Orthology).
OGNtaipale_cyt_meth__NR1I3_NYGAACTWW_FL_meth_reprNR1I3 (directAnnotation).
Page: 1

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."