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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: OAZ2

Summary for OAZ2

Gene information	Gene symbol	OAZ2
	Ensembl ID	ENSG00000180304
	Entrez ID	4947
	Gene name	ornithine decarboxylase antizyme 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O95190

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Dataset with differentially expressed gene: OAZ2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.752523	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.289789	1.90e-19
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.259147	1.77e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.285752	2.93e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.752526	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.335104	6.76e-28
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.29989	0.00e+00

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Expression of OAZ2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to OAZ2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
OAZ2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating OAZ2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
OAZ2	hsa-miR-1291	92.6402	NM_001301302
OAZ2	hsa-miR-6775-3p	92.6402	NM_001301302
OAZ2	hsa-miR-3148	90.6684	NM_001301302
OAZ2	hsa-miR-4749-3p	90.5007	NM_001301302
OAZ2	hsa-miR-1225-3p	90.4597	NM_001301302
OAZ2	hsa-miR-3688-3p	88.6976	NM_001301302
OAZ2	hsa-miR-6124	88.3817	NM_001301302
OAZ2	hsa-miR-570-3p	87.5097	NM_001301302
OAZ2	hsa-miR-4666a-5p	86.9635	NM_001301302
OAZ2	hsa-miR-34c-5p	86.6571	NM_001301302
OAZ2	hsa-miR-449b-5p	86.6571	NM_001301302
OAZ2	hsa-miR-1257	86.4127	NM_001301302
OAZ2	hsa-miR-34a-5p	86.357	NM_001301302
OAZ2	hsa-miR-449a	86.357	NM_001301302
OAZ2	hsa-miR-4319	86.0936	NM_001301302
OAZ2	hsa-miR-210-5p	84.8688	NM_001301302
OAZ2	hsa-miR-3606-5p	82.4874	NM_001301302
OAZ2	hsa-miR-6778-3p	82.1347	NM_001301302
OAZ2	hsa-miR-6764-5p	81.2986	NM_001301302

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Motifs and transcription factors (TFs) regulating OAZ2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
OAZ2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
OAZ2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
OAZ2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
OAZ2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
OAZ2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
OAZ2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
OAZ2	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
OAZ2	metacluster_143.14	ZNF320 (directAnnotation).
OAZ2	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
OAZ2	transfac_pro__M01973	PLAG1 (directAnnotation).
OAZ2	tfdimers__MD00391	KLF4 (directAnnotation).
OAZ2	tfdimers__MD00151	CHURC1 (directAnnotation).
OAZ2	cisbp__M00139	ZNF281 (inferredBy_Orthology).
OAZ2	transfac_pro__M01122	ZNF219 (directAnnotation).
OAZ2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
OAZ2	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
OAZ2	cisbp__M00249	WT1 (directAnnotation).
OAZ2	tfdimers__MD00376	HOXA13; KLF4 (directAnnotation).
OAZ2	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
OAZ2	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
OAZ2	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."