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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: OAZ1

Summary for OAZ1

Gene informationGene symbol

OAZ1

Ensembl ID

ENSG00000104904

Entrez ID

4946

Gene nameornithine decarboxylase antizyme 1
SynonymsAZ1|AZI|MGC138338|OAZ
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: OAZ1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.9415920.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprepDCs-0.4949231.14e-04

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprecDCs-0.3496275.66e-11

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro-0.5750140.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostMono/Macro0.3180751.53e-31

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostcDCs0.2993386.20e-06

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostNK cells0.3847020.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells-0.3893511.92e-12

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprePlasma cells0.4817861.27e-32

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells-0.3612650.00e+00

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells0.4630520.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostNK cells0.2904994.44e-02

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostMono/Macro0.304326.17e-05

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD4+ T cells-0.4158960.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelprePlasma cells-0.4810584.82e-33

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD8+ T cells-0.6473710.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreB cells-0.4568021.83e-39

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreNK cells-0.4415672.40e-34

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelprepDCs-0.6208615.14e-03

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD4+ T cells-0.5161121.79e-16

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAErythrocytes0.2850592.89e-10

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAMono/Macro-0.608354.33e-43

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD8+ T cells-0.3523540.00e+00

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD4+ T cells-0.6150490.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD4+ T cells0.3039971.63e-09

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells0.2655851.99e-08

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preMono/Macro0.2678420.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.3088526.74e-15

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostMalignant cells-0.3034294.98e-07

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMalignant cells0.3434452.23e-09

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.8247070.00e+00

GSE161195

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapyDARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)preMalignant cells0.2743020.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostErythrocytes0.7951041.05e-06

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostCD4+ T cells0.4122843.71e-09

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpreMalignant cells-0.3092070.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells0.9084070.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostErythrocytes1.541930.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostB cells1.179914.96e-04

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells0.9489530.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells0.5088120.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreB cells-0.9601963.56e-04

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostCD8+ T cells0.3376147.23e-04

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreMalignant cells0.3034520.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD4+ T cells0.5690022.78e-05

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells0.3023660.00e+00

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-0.4358680.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostMono/Macro0.2680940.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.352415.07e-36

GSE164897_VemCob

A375 cell lineCell lineMelanomaBRAFV600E-mutant melanomaTargeted therapyvemurafenib + combimetinibNAMalignant cells-1.008530.00e+00

GSE164897_VemTra

A375 cell lineCell lineMelanomaB+E2:E57RAFV600E-mutant melanomaTargeted therapyvemurafenib + trametinibNAMalignant cells-1.01630.00e+00

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Expression of OAZ1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to OAZ1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating OAZ1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
OAZ1hsa-miR-63494.1685NM_001301020
OAZ1hsa-miR-427993.9539NM_001301020
OAZ1hsa-miR-548n92.4976NM_001301020
OAZ1hsa-miR-1213690.8696NM_001301020
OAZ1hsa-miR-548bb-5p88.9918NM_001301020
OAZ1hsa-miR-548w88.9918NM_001301020
OAZ1hsa-miR-548au-5p88.9918NM_001301020
OAZ1hsa-miR-55988.9918NM_001301020
OAZ1hsa-miR-548c-5p88.9918NM_001301020
OAZ1hsa-miR-548ar-5p88.9918NM_001301020
OAZ1hsa-miR-548y88.9918NM_001301020
OAZ1hsa-miR-548ap-5p88.9918NM_001301020
OAZ1hsa-miR-548ay-5p88.9918NM_001301020
OAZ1hsa-miR-548as-5p88.9918NM_001301020
OAZ1hsa-miR-548aq-5p88.9918NM_001301020
OAZ1hsa-miR-548o-5p88.9918NM_001301020
OAZ1hsa-miR-548ab88.9918NM_001301020
OAZ1hsa-miR-548j-5p88.9918NM_001301020
OAZ1hsa-miR-548b-5p88.9918NM_001301020
OAZ1hsa-miR-548ae-5p88.9918NM_001301020
OAZ1hsa-miR-548a-5p88.9918NM_001301020
OAZ1hsa-miR-548i88.9918NM_001301020
OAZ1hsa-miR-548am-5p88.9918NM_001301020
OAZ1hsa-miR-548ak88.9918NM_001301020
OAZ1hsa-miR-548ad-5p88.9918NM_001301020
OAZ1hsa-miR-548d-5p88.9918NM_001301020
OAZ1hsa-miR-548h-5p88.9918NM_001301020
OAZ1hsa-miR-302a-5p86.7272NM_001301020
OAZ1hsa-miR-95-5p85.4863NM_001301020
OAZ1hsa-miR-5187-3p81.1116NM_001301020
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Motifs and transcription factors (TFs) regulating OAZ1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
OAZ1metacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
OAZ1hocomoco__KLF13_HUMAN.H11MO.0.DKLF13 (directAnnotation).
OAZ1jaspar__MA0079.5SP1 (directAnnotation).
OAZ1taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_reprE2F2 (directAnnotation).
OAZ1taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
OAZ1swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
OAZ1transfac_pro__M04748GABPA (directAnnotation).
OAZ1hdpi__TP73TP73 (directAnnotation).
OAZ1taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_reprETV2; HES7 (directAnnotation).
OAZ1metacluster_56.5HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
OAZ1hocomoco__HSF1_HUMAN.H11MO.1.AHSF1 (directAnnotation).
OAZ1cisbp__M01815CEBPE (inferredBy_Orthology).
OAZ1metacluster_46.4CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
OAZ1metacluster_56.4HSF1; HSF2; HSF2; HSF4 (directAnnotation).
OAZ1hocomoco__HSF1_MOUSE.H11MO.1.AHSF1 (inferredBy_Orthology).
OAZ1taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAPATF4; CEBPG (directAnnotation).
OAZ1metacluster_32.19ZNF354A (directAnnotation).
OAZ1transfac_pro__M05887ZNF837 (directAnnotation).
OAZ1metacluster_21.5HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
OAZ1metacluster_90.10ZNF135 (directAnnotation).
OAZ1taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAPATF4; CEBPB (directAnnotation).
OAZ1taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAPATF4; CEBPD (directAnnotation).
OAZ1transfac_pro__M06086ZNF17 (directAnnotation).
OAZ1jaspar__MA0604.1ATF1 (inferredBy_Orthology).
OAZ1tfdimers__MD00027FOXG1; FOXO1; HLTF (directAnnotation).
OAZ1metacluster_130.9ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
OAZ1taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAPATF4; TEF (directAnnotation).
OAZ1metacluster_21.4HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
OAZ1tfdimers__MD00281CDX2; HNF4A; HNF4G; NR2F1; NR2F2 (directAnnotation).
OAZ1metacluster_41.3ZNF354A (directAnnotation).
OAZ1transfac_pro__M05930ZNF286A (directAnnotation).
OAZ1metacluster_156.2ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
OAZ1kznf__ZSCAN29_TF_Evolution_PBMZSCAN29 (directAnnotation).
OAZ1tfdimers__MD00195CDX2; FOXG1; FOXO1 (directAnnotation).
OAZ1tfdimers__MD00009ETS1; ZNF354C (directAnnotation).
OAZ1transfac_pro__M06232ZNF234 (directAnnotation).
OAZ1metacluster_56.3HSF2 (directAnnotation).
OAZ1hocomoco__TYY2_HUMAN.H11MO.0.DYY2 (directAnnotation).
OAZ1flyfactorsurvey__pho_SOLEXA_F1-3YY1 (inferredBy_Orthology).
OAZ1taipale__YY2_DBD_NNCCGCCATNW_reprYY2 (directAnnotation).
OAZ1transfac_pro__M05956BCL11B (directAnnotation).
OAZ1tfdimers__MD00147ELF5; TFAP2C (directAnnotation).
OAZ1taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_reprETV2; RFX5 (directAnnotation).
OAZ1metacluster_155.3PLAG1 (directAnnotation). PLAG1 (inferredBy_Orthology).
OAZ1taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_reprERF; HES7 (directAnnotation).
OAZ1transfac_pro__M05696ZSCAN20 (directAnnotation).
OAZ1metacluster_72.10ZNF697 (directAnnotation).
OAZ1transfac_pro__M06108ZNF43 (directAnnotation).
OAZ1tfdimers__MD00275POU2F1; TFAP2A (directAnnotation).
OAZ1metacluster_79.33YBX1; YBX1; ZNF264 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
OAZ1"Ornithine"

DB00129

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."