Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | cDCs | -0.275705 | 6.01e-03 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | Mono/Macro | -0.316491 | 0.00e+00 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | CD8+ T cells | 0.326596 | 3.99e-15 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | 0.311836 | 1.92e-03 |
GSE104987 | MCF7 cell line | Cell line | Breast cancer | ER+ breast cancer | Targeted therapy | KDM5-C70 | NA | Malignant cells | -0.263576 | 5.78e-12 |
Gene symbol | motif | TF_highConf |
OAS3 | metacluster_2.8 | IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology). |
OAS3 | metacluster_2.6 | IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology). |
OAS3 | metacluster_2.7 | IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology). |
OAS3 | metacluster_2.9 | IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology). |
OAS3 | metacluster_172.21 | SPDEF (inferredBy_Orthology). |
OAS3 | tfdimers__MD00007 | E2F1; IRF8 (directAnnotation). |
OAS3 | metacluster_161.39 | MSX1 (directAnnotation). |
OAS3 | metacluster_161.6 | ALX3 (directAnnotation). |
OAS3 | metacluster_122.17 | IRF6 (directAnnotation). |
OAS3 | taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP | HOXA2; TEAD4 (directAnnotation). |
OAS3 | taipale_tf_pairs__TEAD4_HOXA3_RCATTCNNNNNNCATTA_CAP | HOXA3; TEAD4 (directAnnotation). |
OAS3 | metacluster_161.33 | DLX5 (directAnnotation). |
OAS3 | metacluster_161.34 | MNX1 (directAnnotation). |
OAS3 | taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr | FLI1; FOXI1 (directAnnotation). |
OAS3 | taipale_cyt_meth__TLX3_NAATTGNNNNNNNNNNCAATTN_FL_repr | TLX3 (directAnnotation). |
OAS3 | metacluster_124.1 | BSX (directAnnotation). GBX2 (inferredBy_Orthology). |
OAS3 | tfdimers__MD00527 | IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation). |
OAS3 | metacluster_9.47 | PAX7 (inferredBy_Orthology). |
OAS3 | jaspar__MA1509.1 | IRF6 (directAnnotation). |
OAS3 | transfac_pro__M04887 | TCF12 (directAnnotation). |
OAS3 | homer__GGAAATTCCC_NFkB-p65-Rel | RELA (inferredBy_Orthology). |
OAS3 | taipale_cyt_meth__LMX1B_YTCGTTAW_eDBD_meth | LMX1B (directAnnotation). |
OAS3 | tfdimers__MD00183 | CRX; YY1 (directAnnotation). |
OAS3 | metacluster_161.13 | ISX (directAnnotation). |
OAS3 | taipale_tf_pairs__FOXJ3_ELF1_NNARAAAACCGAAWMN_CAP | ELF1; FOXJ3 (directAnnotation). |
OAS3 | transfac_pro__M06383 | ZNF629 (inferredBy_Orthology). |
OAS3 | taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr | CEBPB; GCM1 (directAnnotation). |
OAS3 | dbtfbs__ZNF664_HEK293_ENCSR714LZQ_merged_N1 | ZNF664 (directAnnotation). |
OAS3 | taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr | ELF1; FOXJ2 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |